Results 31 to 40 of about 14,619 (195)

Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies [PDF]

, 2016
Acknowledgements We thank Craig Lambert for his help in processing the MRS data. The study was funded by the Sir Jules Thorn Charitable Trust (grant ref: 05/JTA) and was supported by the National Institute for Health Research (NIHR) Newcastle Biomedical ...
Blamire, A. M., Hayes, L., He, J., O'Brien, J. T., Su, L., Watson, R.   +5 more
core   +2 more sources

Magnetic resonance spectroscopy in migraine: what have we learned so far? [PDF]

, 2012
Objective: To summarize and evaluate proton (H-1) and phosphorus (P-31) magnetic resonance spectroscopy (MRS) findings in migraine. Methods: A thorough review of H-1 and/or P-31-MRS studies in any form of migraine published up to September 2011 ...
Achten, Eric, Paemeleire, Koen, Reyngoudt, Harmen   +2 more
core   +2 more sources

Magnetic resonance markers of tissue damage related to connectivity disruption in multiple sclerosis

NeuroImage: Clinical, 2018
Patients with multiple sclerosis (MS) display reduced structural connectivity among brain regions, but the pathogenic mechanisms underlying network disruption are still unknown.
Elisabeth Solana, Eloy Martinez-Heras, Elena H. Martinez-Lapiscina, Maria Sepulveda, Nuria Sola-Valls, Nuria Bargalló, Joan Berenguer, Yolanda Blanco, Magi Andorra, Irene Pulido-Valdeolivas, Irati Zubizarreta, Albert Saiz, Sara Llufriu   +12 more
doaj   +1 more source

Role of Increased n-acetylaspartate Levels in Cancer. [PDF]

J Natl Cancer Inst, 2016
The clinical and biological effects of metabolic alterations in cancer are not fully understood.In high-grade serous ovarian cancer (HGSOC) samples (n = 101), over 170 metabolites were profiled and compared with normal ovarian tissues (n = 15). To determine NAT8L gene expression across different cancer types, we analyzed the RNA expression of cancer ...
Zand B, Previs RA, Zacharias NM, Rupaimoole R, Mitamura T, Nagaraja AS, Guindani M, Dalton HJ, Yang L, Baddour J, Achreja A, Hu W, Pecot CV, Ivan C, Wu SY, McCullough CR, Gharpure KM, Shoshan E, Pradeep S, Mangala LS, Rodriguez-Aguayo C, Wang Y, Nick AM, Davies MA, Armaiz-Pena G, Liu J, Lutgendorf SK, Baggerly KA, Eli MB, Lopez-Berestein G, Nagrath D, Bhattacharya PK, Sood AK.   +32 more
europepmc   +5 more sources

GLIAL HEMICHANNELS: A NEW ROUTE FOR CHEMICAL COMMUNICATION IN BRAIN [PDF]

, 2008
The extracellular neurochemistry determines normal brain function and the faith of neurons after insults such as stroke. This thesis concerns the effect of extracellular events related to intense neuronal stimulation and stroke, i.e.
Stridh, Malin
core   +1 more source

Decreased left frontal lobe N-acetylaspartate in schizophrenia [PDF]

American Journal of Psychiatry, 1997
The authors measured N-acetylaspartate (a putative neuronal marker), using in vivo proton magnetic resonance spectroscopic imaging (1H-MRSI), in the frontal lobes of schizophrenic patients and normal subjects.Frontal lobe 1H-MRSI was performed bilaterally on 24 medicated schizophrenic patients and 15 healthy comparison subjects.
R F, Deicken, L, Zhou, F, Corwin, S, Vinogradov, M W, Weiner   +4 more
openaire   +2 more sources

N-Acetyl and Glutamatergic Neurometabolites in Perisylvian Brain Regions of Methamphetamine Users. [PDF]

, 2018
Background:Methamphetamine induces neuronal N-acetyl-aspartate synthesis in preclinical studies. In a preliminary human proton magnetic resonance spectroscopic imaging investigation, we also observed that N-acetyl-aspartate+N-acetyl-aspartyl-glutamate in
Alger, Jeffry R, Johnson, Maritza C, London, Edythe D, O'Neill, Joseph, Shen, Zhiwei, Tang, Jinsong   +5 more
core   +2 more sources

Education mitigates age‐related decline in N‐Acetylaspartate levels [PDF]

Brain and Behavior, 2015
AbstractBackgroundGreater educational attainment is associated with better neurocognitive health in older adults and is thought to reflect a measure of cognitive reserve. In vivo neuroimaging tools have begun to identify the brain systems and networks potentially responsible for reserve.MethodsWe examined the relationship between education, a commonly ...
Erickson, Kirk I, Leckie, Regina L, Weinstein, Andrea M, Radchenkova, Polina, Sutton, Bradley P, Prakash, Ruchika Shaurya, Voss, Michelle W, Chaddock-Heyman, Laura, McAuley, Edward, Kramer, Arthur F   +9 more
openaire   +2 more sources

Neurometabolites alteration in the acute phase of mild traumatic brain injury (mTBI): an in vivo proton magnetic resonance spectroscopy (1H-MRS) study [PDF]

, 2018
Rationale and Objectives: Magnetic resonance spectroscopy is a noninvasive imaging technique that allows for reliable assessment of microscopic changes in brain cytoarchitecture, neuronal injuries, and neurochemical changes resultant from traumatic ...
Hernowo, Aditya Tri, Narayanan, Vairavan, Ramli, Norlisah, Seow, PohChoo, Tan, Li Kuo, Veeramuthu, Vigneswaran, Wong, Jeannie Hisu Ding   +6 more
core   +1 more source

Serial 1H-NMR Spectroscopy Study of Metabolic Impairment in Primates Chronically Treated with the Succinate Dehydrogenase Inhibitor 3-Nitropropionic Acid

Neurobiology of Disease, 1999
Previous studies in primates have shown that chronic systemic administration of the succinate dehydrogenase (SDH) inhibitor, 3-nitropropionic acid (3NP), replicates most of the motor, cognitive, and histopathological features of Huntington's disease.
Caroline Dautry, Francoise Condé, Emmanuel Brouillet, Vincent Mittoux, M.Flint Beal, Gilles Bloch, Philippe Hantraye   +6 more
doaj   +1 more source