Results 51 to 60 of about 14,619 (195)

Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication

Frontiers in Psychiatry, 2021
In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification
Guoying Wang, Wolfgang Weber-Fahr, Ulrich Frischknecht, Ulrich Frischknecht, Derik Hermann, Derik Hermann, Falk Kiefer, Gabriele Ende, Markus Sack   +8 more
doaj   +1 more source

Glutathione Deficit Affects the Integrity and Function of the Fimbria/Fornix and Anterior Commissure in Mice: Relevance for Schizophrenia. [PDF]

, 2015
Structural anomalies of white matter are found in various brain regions of patients with schizophrenia and bipolar and other psychiatric disorders, but the causes at the cellular and molecular levels remain unclear.
Corcoba, A., Cuenod, M., Do, K.Q., Duarte, J.M., Gruetter, R., Monin, A., Steullet, P., Van de Looij, Y.   +7 more
core   +2 more sources

Exploring the Association between Cathepsin B and Parkinson’s Disease

Brain Sciences
Objective: The aim of this study is to investigate the association between Cathepsin B and Parkinson’s Disease (PD), with a particular focus on determining the role of N-acetylaspartate as a potential mediator.
Changhao Lu, Xinyi Cai, Shilin Zhi, Xiaofen Wen, Jiaxin Shen, Tommaso Ercoli, Elena Rita Simula, Carla Masala, Leonardo A. Sechi, Paolo Solla   +9 more
doaj   +1 more source

Design of Optical Transducer for Recognition of Biomolecular Interactions between Bacterial Lipopolysaccharides and Amino Acids

Advanced Science, EarlyView.
A deep comprehension of biomolecular phenomena at interfaces is significant with their fundamental and practical importance. Our experimental and theoretical investigations reveal that specific amino acids (glutamic acid and aspartic acid) exhibit an orientational coupling with liquid crystals, which can recognize and optically report the interfacial ...
Yena Choi, Sangmin Lee, Jin‐Kang Choi, Hyunsoo Han, Yeongseon Choi, Jun‐Hyung Im, Hyein Kim, Sangmin Jeon, Minjae Lee, Chang Yun Son, Young‐Ki Kim   +10 more
wiley   +1 more source

N-Acetylaspartate Improves Cell Survival When Glucose is Limiting [PDF]

SSRN Electronic Journal, 2020
SummaryN-acetylasparate (NAA), previously considered a brain-specific metabolite, is found in several cancers. However, whether it plays a role in tumor growth or survival is not fully understood. We provide evidence that NAA prevents cell death in low-glucose conditions via sustaining intracellular UDP-N-acetylglucosamine (UDP-GlcNac) levels ...
H. Furkan Alkan, Katharina E. Walter, Hubert Hackl, Matthew G. Vander Heiden, Tobias Madl, Juliane G. Bogner-Strauss   +5 more
openaire   +1 more source

Thalamic Metabolism and Restless Legs Syndrome

Pediatric Neurology Briefs, 2013
Researchers at University of Bologna, Italy, evaluated medial thalamus metabolism and structural integrity in 23 patients with restless legs syndrome and 19 healthy controls.
J Gordon Millichap
doaj   +1 more source

Neural plasticity in common forms of chronic headaches [PDF]

, 2015
Headaches are universal experiences and among the most common disorders. While headache may be physiological in the acute setting, it can become a pathological and persistent condition.The mechanisms underlying the transition from episodic to chronic ...
Chen, Wei-Ta, Cheng, Yu-Chen, Coppola, Gianluca, Lai, Tzu-Hsien, Loggia, Marco L., Protsenko, Ekaterina   +5 more
core   +4 more sources

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Left frontal lobe N-acetylaspartate levels in patients with deficit schizophrenia

Psychiatry and Clinical Psychopharmacology, 2021
Objective: This study aimed to detect the N-acetylaspartate levels of the left frontal lobe in patients with deficit schizophrenia. Method: Schizophrenia was diagnosed using the DSM-IV criteria.
Barbaros Özdemir, Özcan Uzun, Aytekin Özşahin, Salih Battal   +3 more
doaj  

Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users [PDF]

, 2014
Rationale: Ketamine, a non-competitive NMDA receptor antagonist, induces acute effects resembling the positive, negative and cognitive symptoms of schizophrenia.
Fam, Johnson, Furby, Hannah, Howes, Oliver D., Hughes, Emer, Morgan, Celia, Pepper, Fiona, Stone, James M.   +6 more
core   +1 more source