Results 161 to 170 of about 14,734,718 (295)

Common Food Emulsifiers Impair Epithelial Barrier Integrity and Trigger Pro‐Inflammatory Responses and IgE Production

Allergy, EarlyView.
Soy lecithin and DATEM, the two commonly used food emulsifiers introduced into many foods including peanut butter and puffed bread, in the 2000s, impair intestinal epithelial barrier integrity in human gut‐on‐a‐chip and induced pluripotent stem cell colon organoid models.
Duygu Yazici, Yuka Hayashi, Yagiz Pat, Jennifer Hotie, Mehmet Ali Balci, Sena Ardicli, Juan Felipe Lopez, Ozge Ardicli, Bingjie Zhao, Angel Maldonado, Can Zeyneloglu, Kenji Matsumoto, Manru Li, Beate Rückhert, Lihong Chang, Ismail Ogulur, Vahap Eldem, Raja Dhir, Mubeccel Akdis, Kari Nadeau, Oscar Palomares, Hideaki Morita, Cezmi A. Akdis   +22 more
wiley   +1 more source

An evaluation of N-acetylcysteine in a sequential oxycodone and cocaine rat self-administration model. [PDF]

Exp Clin Psychopharmacol
Corley C, McNealy KR, White AM, McManus H, Khatri SN, Stoops WW, Gipson CD.   +6 more
europepmc   +1 more source

Extracorporeal Albumin Dialysis (OPAL) as Novel Therapeutic Bridging Option in Posthepatectomy Liver Failure

Artificial Organs, EarlyView.
Extracorporeal albumin dialysis (OPAL) effectively reduces bilirubin and improves other laboratory markers in posthepatectomy liver failure, particularly in secondary forms. It may serve as a bridging therapy to support hepatic recovery in critically ill patients, although prospective studies are needed to confirm its impact on survival.
Dorian Marckmann, Emely Wack, Luisa Schäfer, H. Christian Hillebrecht, Francesca Reimer, Gabriel Stöger, Klara Krötzsch, Magdalena Menzel, Lampros Kousoulas, Stefan Utzolino, Stefan Fichtner‐Feigl, Dawid L. Staudacher, Frederic Arnold, Thomas Welte, Philipp Holzner, Felix A. Rottmann, Christopher Berlin   +16 more
wiley   +1 more source

Experimental evaluation of N-acetylcysteine against doxorubicin cardiotoxicity in rats. [PDF]

BMC Pharmacol Toxicol
Tola HT, Kılıç S.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

A randomized controlled trial of N-acetylcysteine in the treatment of early-onset preeclampsia: Study Protocol. [PDF]

PLoS One
Okunade KS, Adejimi AA, Adenekan MA, Ademuyiwa IY, Adelabu H, Habeebu-Adeyemi FM, Soibi-Harry AP, Onasanya O, Fayinto AI, Adekanye TV, Adeboje-Jimoh F, Oghide O, Davies NO, Akhenamen P, Olowoselu FO, Okusanya BO.   +15 more
europepmc   +1 more source

Ketogenic Diet and β‐Hydroxybutyrate Suppress Bladder Cancer Growth and Enhance Anti‐PD‐L1 Immunotherapy Efficacy

Cancer Science, EarlyView.
Ketogenic diet and β‐hydroxybutyrate (β‐HB) suppress bladder cancer growth through direct anti‐tumor mechanisms and enhance anti‐PD‐L1 immunotherapy efficacy. β‐HB upregulates PD‐L1 via JAK2‐STAT3 activation and remodels the tumor immune microenvironment, sensitizing tumors to immune checkpoint blockade. ABSTRACT The limited clinical efficacy of immune
Yuan Zeng, Gangli Gu, Lin Yang, Bohao Fan, Haochen Cui, Lei Yan, Zhao Liu   +6 more
wiley   +1 more source

Morphological and Biochemical Insights Into the Renoprotective Effects of Combined N-Acetylcysteine and Glycine Treatment in Experimental Diabetic Nephropathy. [PDF]

Pharmacol Res Perspect
Ejubović M, Belančić A, Lam YW, Javid F, Kapić D, Ćosović E, Jahić R, Lepara O, Ejubović AJ, Alić L, Topuz A, Ajanović Z, Fajkić A.   +12 more
europepmc   +1 more source

Collagen Type VI Alpha 1 as a Regulator of Redox Homeostasis in Antioxidant‐Enhanced Osteogenesis of Dental Stem Cells

Cell Proliferation, EarlyView.
Under physiological conditions, NAC activates the PI3K‐AKT‐COL6A1 axis to sustain redox balance and enhance osteogenesis. COL6A1 deficiency, however, compromises this axis, inducing oxidative stress and impairing NAC's osteogenic efficacy. ABSTRACT Alveolar bone injury represents a prevalent clinical challenge in dentistry, for which stem cell‐based ...
Zhaosong Meng, Jiacheng Liu, Yue Zhang, Ruimeng Yang, Jingyi Zhang, Haosun Yang, Zheng Wang, Ran Wei, Zhe Li, Shuling Guo, Lizhi Hu, Lei Sui   +11 more
wiley   +1 more source

Unraveling the complex role of intestinal microbiota in drug permeability: Insights from N-acetylcysteine. [PDF]

Asian J Pharm Sci
Tian C, He Z.
europepmc   +1 more source