Results 171 to 180 of about 74,982 (294)

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

open access: yesMedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi   +2 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

open access: yesMedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang   +14 more
wiley   +1 more source

Glutathione‐Related Metabolite Levels and Enzyme Activities in Depression: A Systematic Review and Meta‐Analysis

open access: yesNeuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
We conducted a systematic review and meta‐analysis to compare the levels of glutathione‐related metabolites. Our meta‐analysis indicated significantly decreased activity of glutathione‐peroxidase in patients with depression compared with healthy controls, while the levels of glutathione and glutathione reductase were not significantly different between
Takahide Etani   +16 more
wiley   +1 more source

Dietary N-acetylcysteine enhances sperm motility by remodeling the rumen microbiome and its metabolic axis in goats. [PDF]

open access: yesJ Anim Sci Biotechnol
Luo J   +11 more
europepmc   +1 more source

Evolution of Thiosemicarbazones: From First‐ to Second‐Generation Metal Chelators and Their Reactive Oxygen Species‐Mediated Effects in Melanoma

open access: yesChemistryOpen, Volume 15, Issue 6, June 2026.
Thiosemicarbazones (TSC) have demonstrated promise as new chemotherapeutic agents against melanoma in both in vitro and In vivo studies. TSC are powerful metal coordinating agents, coordinating transition metal ions such as zinc, copper and iron in multiple oxidation states. It is this metal coordination that imparts the anticancer activity.
Rohina Alim   +2 more
wiley   +1 more source

Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Viruses such as Ebola, Marburg, influenza, mpox, MERS‐CoV, SARS‐CoV, and SARS‐CoV‐2 may be considered pathogens of epidemic or pandemic concern. Developing novel antiviral medicines can be time‐consuming and resource intensive. Repurposing existing medicines with known or potential antiviral activity offers a faster, cost‐effective strategy to
Sola Akinbolade   +5 more
wiley   +1 more source

Successful use of haemoperfusion therapy in an adult horse with hepatic encephalopathy and cholangiohepatitis

open access: yesEquine Veterinary Education, Volume 38, Issue 6, Page e307-e314, June 2026.
Summary A 4‐year‐old, 520 kg, American Quarter Horse broodmare, approximately 90 days in foal, was presented to Texas A&M University Teaching Hospital for suspected liver disease. Based on clinicopathological values and hepatic abnormalities noted ultrasonographically, the mare was presumptively diagnosed with cholangiohepatitis.
A. C. Trimble   +6 more
wiley   +1 more source

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