Results 191 to 200 of about 74,982 (294)

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, Volume 13, Issue 27, 13 May 2026.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Administration of N-acetylcysteine influence the expression of apoptotic genes in the granulosa cells of infertile women diagnosed with endometriosis. [PDF]

Sci Rep
Heshmati ZS, Amiri-Yekta A, Khosravifar M, Akbarian F, Moini A, Eftekhari-Yazdi P, Hafezi M, Afsharian P.   +7 more
europepmc   +1 more source

Luteolin Protects Against Noise‐Induced Hearing Loss via Mitigating Oxidative Stress and Apoptosis, With Potential Regulation of the EGR1/SPRY4 Axis

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Luteolin attenuates noise‐induced auditory hair cell loss, as well as TBHP‐induced oxidative stress and apoptosis. EGR1 modulates the transcription of SPRY4; the expression levels of both factors are upregulated following TBHP exposure, and this inductive effect is abrogated by luteolin treatment.
Jia‐ning Guo, Hong‐kai Mei, Rui Liang, Peng‐wei Ma, Wei‐long Wang, Jia‐wei Chen, Zi Wang, Hao Yuan, Yu‐qiang Lun, Wei Gao, Lian‐jun Lu   +10 more
wiley   +1 more source

N-acetylcysteine in paediatrics: a review of efficacy, safety and dosing strategies in respiratory care. [PDF]

Drugs Context
Benedetti F, Santus P.
europepmc   +1 more source

Fat composition in infant formula contributes to the severity of necrotising enterocolitis [PDF]

, 2018
Das, Tapas, Fulton, William B, Good, Misty, Hackam, David J, Jia, Hongpeng, Lai, Chron-Si, Lu, Peng, Ozolek, John A, Prindle, Thomas, Jr, Sodhi, Chhinder P, Vurma, Mustafa, Yamaguchi, Yukihiro   +11 more
core   +1 more source

Cryptocaryone Exhibits ROS/MAPK‐Dependent Antiproliferative and Apoptosis‐Inducing Effects on Triple‐Negative Breast Cancer Cells and Proof‐of‐Concept Breast Cancer Mouse Model

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT Omics’ technologies have enabled clinicians to gain previously unprecedented insights into the molecular complexity and clinical heterogeneity of triple‐negative breast cancer (TNBC). Increasingly it is being realized that TNBC does not respond well to current targeted therapies.
Ya‐Ting Chuang, Wangta Liu, Tsu‐Ming Chien, Ammad Ahmad Farooqi, Hsun‐Shuo Chang, Jun‐Ping Shiau, Hsueh‐Wei Chang   +6 more
wiley   +1 more source

Efficacy of Dextromethorphan Augmentation in SSRI‐Resistant Obsessive–Compulsive Disorder: A Randomized Controlled Trial

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Obsessive–compulsive disorder (OCD) is a chronic condition associated with marked functional impairment and high rates of treatment resistance. Converging evidence implicates glutamatergic dysregulation in OCD pathophysiology.
Ahmad Zolghadriha, Afagh Anjomshoaa, Romina Bagheri   +2 more
wiley   +1 more source

What is the optimal dose of N-acetylcysteine in adult patients with bronchiectasis?-data from the RIBRON registry. [PDF]

J Thorac Dis
Oscullo G, Méndez R, Olveira C, Girón R, García-Clemente M, Máiz L, Sibila O, Golpe R, Rodríguez-Hermosa JL, Barreiro E, Prados C, Rodríguez-Lopez J, de la Rosa D, Martinez-García MÁ.   +13 more
europepmc   +1 more source

Antenatal Presentation of MRPS22‐Related Mitochondrial Disease Confirmed With Rapid Proteomics

JIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT MRPS22‐related mitochondrial disease (MIM#611719) is a rare autosomal recessive disorder caused by defects in the mitochondrial ribosomal protein S22, a component of the small mitoribosomal subunit essential for mitochondrial translation. Of the few reported cases, most present antenatally with a severe phenotype, conveying a poor prognosis ...
Liana N. Semcesen, Megan Ball, Daniella H. Hock, Juliet Kaye, Aimee Woods, Lucas De Jong, MitoMDT Diagnostic Network for Genomics and Omics, David R. Thorburn, Aleksandra Filipovska, Michael T. Ryan, David A. Stroud, Diana Stojanovski, David Coman, Sean Murray, Ryan L. Davis, John Christodoulou, Suzanne C. E. H. Sallevelt, Roula Ghaoui, Cas Simons, Stefan J. Siira, Shanti Balasubramaniam, Alison G. Compton, Daniel G. MacArthur, Nicole J. Lake, Drago Bratkovic, Joy Lee, Maina Kava, Amanda Samarasinghe, Yoni Elbaum, Catherine Atthow, Pauline McGrath, Tegan Stait, Rocio Rius, Liana N. Semcesen, Megan Ball, Daniella Hock, Luke E. Formosa, Ellenore M. Martin, Madeleine Harris, John Christodoulou, David R. Thorburn, Alison G. Compton, David A. Stroud, Jan Liebelt   +43 more
wiley   +1 more source

N-Acetylcysteine Dose and Treatment Duration in High-Risk Acetaminophen Ingestions Treated Within Eight Hours: A Retrospective Cohort Study. [PDF]

J Med Toxicol
Watson CJ, Simpson MD, Saraiya N, Wilkosz CA, Yu MB, Burns MM, Neavyn MJ, Simone KE, Strout TD.   +8 more
europepmc   +1 more source