Results 191 to 200 of about 44,243 (239)
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The promise of N-acetylcysteine in neuropsychiatry
Trends in Pharmacological Sciences, 2013N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant glutathione, neurotrophins, apoptosis, mitochondrial function, and inflammatory pathways.
Michael, Berk +3 more
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Pharmacokinetics of N-acetylcysteine in man
European Journal of Clinical Pharmacology, 1986N-Acetylcysteine was given intravenously and as three fast dissolving and one slow-release formulation, on separate occasions, as a single dose of 600 mg to 10 fasting (5 men and 5 women) healthy volunteers. Blood and urine were sampled for the following 12 h. Renal clearance constituted around 30% of total body clearance, which was 0.21 l/h/kg. Volume
L, Borgström, B, Kågedal, O, Paulsen
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Hyperthyroidism and N-Acetylcysteine
Journal of the American Medical Directors Association, 2021Seema, Rao, S, Rao
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Lipoprotein(a) reduction by N-acetylcysteine
The Lancet, 1991Lipoprotein(a), a complex of low-density lipoprotein linked by disulphide bridges with apo(a), is associated with atherosclerotic disease when present at very high plasma concentrations. In vitro, N-acetylcysteine (NAC) dissociates this complex. In two patients with high Lp(a) levels NAC lowered plasma Lp(a) from 58 to 20 mg/dl and from 59 to 18 mg/dl:
D, Gavish, J L, Breslow
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Chemico-Biological Interactions, 2014
Geldanamycin (GDN) is a benzoquinone ansamycin antibiotic with anti-proliferative activity on tumor cells. GDN cytotoxicity has been attributed to the disruption of heat shock protein 90 (Hsp90) binding and stabilizing client proteins, and by the induction of oxidative stress with concomitant glutathione (GSH) depletion.
Petr, Mlejnek, Petr, Dolezel
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Geldanamycin (GDN) is a benzoquinone ansamycin antibiotic with anti-proliferative activity on tumor cells. GDN cytotoxicity has been attributed to the disruption of heat shock protein 90 (Hsp90) binding and stabilizing client proteins, and by the induction of oxidative stress with concomitant glutathione (GSH) depletion.
Petr, Mlejnek, Petr, Dolezel
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N-acetylcysteine-cysteine disulfide excretion in the urine following N-acetylcysteine administration
The Journal of Pediatrics, 1969Summary Three patients taking N-acetylcysteine asa topical pulmonary mucolytic agent have been shown to excrete in urine the mixed disulfide of this compound with cysteine. The disulfide gives a positive cyanide-nitroprusside test and may be easily confused by paper chromatography with beta-mercaptolactate-cysteine disulfide, a substance excreted in ...
V E, Shih, J D, Schulman
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Clinical Pharmacokinetics of N-Acetylcysteine
Clinical Pharmacokinetics, 1991N-Acetylcysteine is useful as a mucolytic agent for treatment of chronic bronchitis and other pulmonary diseases complicated by the production of viscous mucus. It is also used as an antidote to paracetamol (acetaminophen) poisoning and found to be effective for the prevention of cardiotoxicity by doxorubicin and haemorrhagic cystitis from ...
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N-Acetylcysteine in Kidney Disease
2010Acute kidney injury (AKI) is a frequent complication of contrast administration (contrast-induced nephropathy) and cardiac surgery and is associated with increased short-term and long-term morbidity and mortality. Acute kidney injury is becoming a growing problem in modern cardiovascular medicine, in parallel with the increase in application of ...
G. Marenzi, E. Sisillo, A. Bartorelli
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1994
Sepsis, septic shock and multiple organ dysfunction syndrome are characterized by progressive inadequate tissue perfusion and maldistribution of blood flow [1]. Endothelium-derived relaxing factor is considered to be important in maintaining nutrive blood flow [2].
C. Spies, K. Reinhart
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Sepsis, septic shock and multiple organ dysfunction syndrome are characterized by progressive inadequate tissue perfusion and maldistribution of blood flow [1]. Endothelium-derived relaxing factor is considered to be important in maintaining nutrive blood flow [2].
C. Spies, K. Reinhart
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