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ALSUntangled #82: N-acetylcysteine
Amyotrophic Lateral Sclerosis and Frontotemporal DegenerationN-acetylcysteine is a thiol-containing compound and a precursor of glutathione, with mechanistic plausibility for ALS, including reducing oxidative stress, regulating neuroinflammation, and mitigating mitochondrial dysfunction. Preclinical studies have yielded conflicting results on whether N-acetylcysteine can delay the onset of motor impairment and ...
Sandeep Yerraguntla +34 more
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Alternative medicine review : a journal of clinical therapeutic, 2000
N-acetylcysteine (NAC) is the acetylated precursor of both the amino acid L-cysteine and reduced glutathione (GSH). Historically it has been used as a mucolytic agent in chronic respiratory illnesses as well as an antidote for hepatotoxicity due to acetaminophen overdose.
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N-acetylcysteine (NAC) is the acetylated precursor of both the amino acid L-cysteine and reduced glutathione (GSH). Historically it has been used as a mucolytic agent in chronic respiratory illnesses as well as an antidote for hepatotoxicity due to acetaminophen overdose.
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N-Acetylcysteine and addiction
Arbor Clinical Nutrition Updates, 2009In a nutshellThe rationale for using N-Acetylcysteine to treat addiction is because it influences glutamate handling in the brain, and an excess of this excitatory neurotransmitter is known to be associated with various forms of addiction.Animal and particularly human clinical trial data is insufficient to allow any definitive conclusion, but this is ...
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1994
Publisher Summary N-Acetylcysteine (NAC) is a thiol-containing compound that has been used in clinical practice for several years. Historically, NAC was introduced for the treatment of congestive and obstructive lung diseases; primarily those associated with hypersecretion of mucus, for example, chronic bronchitis and cystic fibrosis.
Peter Moldéus, Ian A. Cotgreave
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Publisher Summary N-Acetylcysteine (NAC) is a thiol-containing compound that has been used in clinical practice for several years. Historically, NAC was introduced for the treatment of congestive and obstructive lung diseases; primarily those associated with hypersecretion of mucus, for example, chronic bronchitis and cystic fibrosis.
Peter Moldéus, Ian A. Cotgreave
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Anaphylactoid reactions to N-acetylcysteine
Clinical Toxicology, 2013James Michael, Coulson +1 more
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