Results 261 to 270 of about 14,734,718 (295)

Lipoprotein(a) reduction by N-acetylcysteine

The Lancet, 1991
Lipoprotein(a), a complex of low-density lipoprotein linked by disulphide bridges with apo(a), is associated with atherosclerotic disease when present at very high plasma concentrations. In vitro, N-acetylcysteine (NAC) dissociates this complex. In two patients with high Lp(a) levels NAC lowered plasma Lp(a) from 58 to 20 mg/dl and from 59 to 18 mg/dl:
D, Gavish, J L, Breslow
openaire   +2 more sources

Repeated-dose Oral N-acetylcysteine in Parkinson Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress

Journal of clinical pharmacology, 2017
Parkinson's disease (PD) is associated with oxidative stress and decreased nigral glutathione (GSH), suggesting that therapies that boost GSH may have a disease‐modifying effect. Intravenous administration of a high dose of N‐acetylcysteine (NAC), a well‐
L. Coles, P. Tuite, G. Öz, U. Mishra, Reena V. Kartha, Kathleen M. Sullivan, James C. Cloyd, M. Terpstra   +7 more
semanticscholar   +1 more source

Clinical Pharmacokinetics of N-Acetylcysteine

Clinical Pharmacokinetics, 1991
N-Acetylcysteine is useful as a mucolytic agent for treatment of chronic bronchitis and other pulmonary diseases complicated by the production of viscous mucus. It is also used as an antidote to paracetamol (acetaminophen) poisoning and found to be effective for the prevention of cardiotoxicity by doxorubicin and haemorrhagic cystitis from ...
openaire   +2 more sources

N-Acetylcysteine in Kidney Disease

2010
Acute kidney injury (AKI) is a frequent complication of contrast administration (contrast-induced nephropathy) and cardiac surgery and is associated with increased short-term and long-term morbidity and mortality. Acute kidney injury is becoming a growing problem in modern cardiovascular medicine, in parallel with the increase in application of ...
G. Marenzi, E. Sisillo, A. Bartorelli
openaire   +2 more sources

N‐acetylcysteine ameliorates cisplatin‐induced renal senescence and renal interstitial fibrosis through sirtuin1 activation and p53 deacetylation

Free Radical Biology & Medicine, 2019
The mechanism underlying the development of chronic kidney disease (CKD) after acute kidney injury (AKI) remains unclear. Maladaptive repair has been considered an important mechanism of CKD post AKI.
Caizhen Li, Na Xie, Yan Li, Chongbin Liu, F. Hou, Jun Wang   +5 more
semanticscholar   +1 more source

N-acetylcysteine prevents the geldanamycin cytotoxicity by forming geldanamycin–N-acetylcysteine adduct

Chemico-Biological Interactions, 2014
Geldanamycin (GDN) is a benzoquinone ansamycin antibiotic with anti-proliferative activity on tumor cells. GDN cytotoxicity has been attributed to the disruption of heat shock protein 90 (Hsp90) binding and stabilizing client proteins, and by the induction of oxidative stress with concomitant glutathione (GSH) depletion.
Petr, Mlejnek, Petr, Dolezel
openaire   +2 more sources

N-acetylcysteine-cysteine disulfide excretion in the urine following N-acetylcysteine administration

The Journal of Pediatrics, 1969
Summary Three patients taking N-acetylcysteine asa topical pulmonary mucolytic agent have been shown to excrete in urine the mixed disulfide of this compound with cysteine. The disulfide gives a positive cyanide-nitroprusside test and may be easily confused by paper chromatography with beta-mercaptolactate-cysteine disulfide, a substance excreted in ...
V E, Shih, J D, Schulman
openaire   +2 more sources

Amelioration of fenitrothion induced oxidative DNA damage and inactivation of caspase-3 in the brain and spleen tissues of male rats by N-acetylcysteine.

Life Science, 2019
N-acetylcysteine (NAC) has largely been used as an effective chemo- protective agent owing to their beneficial effect in restoring several physiological parameters and relieving oxidative stress.
R. T. Alam, T. Imam, A. Abo-Elmaaty, A. Arisha   +3 more
semanticscholar   +1 more source

N-Acetylcysteine

Revue de l'infirmiere, 2010
Jean-Michel Scherrmann, Kim Wolff, Christine A. Franco, Marc N. Potenza, Tayfun Uzbay, Lisiane Bizarro, David C. S. Roberts, Robert L. Balster, Sharon L. Walsh, Barbara J. Mason, Charles J. Heyser, Anthony L. Riley, Steve Kohut, Marie-Louise G. Wadenberg, Heather Wilkins, Paul Newhouse, Anne Jackson, Joachim D. Uys, Peter W. Kalivas, Victoria L. Harvey, Tony Dickenson, Daniel Bertrand, Hans Rollema, Raymond S. Hurst, Gorkem Yararbas, Sakire Pogun, Marie-Louise G. Wadenberg, Debby Van Dam, Peter Paul De Deyn, Samuel G. Siris, Richard W. Foltin, Michael J. Kuhar, Robert L. Balster, Sharon L. Walsh, Robert L. Balster, Sharon L. Walsh, Michel Le Moal, Christoph Hiemke, Nicola Simola, Micaela Morelli, Nicola Simola, Micaela Morelli, Nicola Simola, Micaela Morelli, Alyson J. Bond, James J. Strain, R. Andrew Chambers, R. H. De Rijk, E. R. de Kloet, Bankole A. Johnson, Andreas Marneros, Suzanne H. Mitchell, Harriet de Wit, Mark Slifstein, Klaus A. Miczek, Rosa M. M. de Almeida, Emil F. Coccaro, David S. Baldwin, John Atack, Hilde Lavreysen, Rosa M. M. de Almeida, Klaus A. Miczek, Alyson J. Bond, Alfonso Abizaid, Shimon Amir, Samuel G. Siris, Joseph H. Friedman, Theodora Duka, Jelena Nesic, Falk Kiefer, Karl Mann, Bankole A. Johnson, Barbara J. Mason, Charles J. Heyser, Karl Mann, Falk Kiefer, Christopher L. Cunningham, Barbara J. Mason, Charles J. Heyser, Yesne Alici, William Breitbart, Subhash C. Pandey, Karl Mann, Falk Kiefer, Kieran O’Malley, Kieran O’Malley, Mitul A. Mehta, Linda Dykstra, John Atack, Hilde Lavreysen, Debby Van Dam, Peter Paul De Deyn, Holden D. Brown, Michael E. Ragozzino, Brian E. Leonard, Malcolm Lader, Peter J. Flor, Inga D. Neumann, Linda P. Spear, Holden D. Brown, Michael E. Ragozzino, Daniel Hoyer, Martina de Zwaan, Michael J. Owens, Chase H. Bourke, Philip J. Cowen, Pedro L. Delgado, Hiroyuki Uchida, Shitij Kapur, Harriet de Wit, Lawrence H. Price, Malcolm Lader, Husseini K. Manji, Jorge A. Quiroz, Seiya Miyamoto, Francisco Aboitiz, Ximena Carrasco, F. Xavier Castellanos, Michael J. Owens, Chase H. Bourke, Elizabeth C. Warburton, Husseini K. Manji, Jorge A. Quiroz, Linda Dykstra, James H. Woods, Mei-Chuan Ko, Gail Winger, Andrew Young, Jill B. Becker, Helen J. Cassaday, Paul Willner, Maria Isabel Colado, A. Richard Green, Marilyn E. Carroll, Peter A. Santi, Iván Izquierdo, Lia R. Bevilaqua, Martin Cammarota, Alfonso Abizaid, Shimon Amir, Jason C. G. Halford, Arthur Christopoulos, Gregory D. Stewart, Patrick M. Sexton, Sheldon Preskorn, Megan M. Dahmen, Jana Lincoln, Edoardo Spina, Brian E. Leonard, J. Craig Nelson, Meghan M. Grady, Stephen M. Stahl, Thomas R. E. Barnes, Michael M. Morgan, MacDonald J. Christie, Linda Dykstra, Joseph H. Friedman, Marie-Louise G. Wadenberg, Wiepke Cahn, Heleen B. M. Boos, H. D. Postma, Seiya Miyamoto, W. Wolfgang Fleischhacker, Samuel B. Hutton, Peter J. Flor, Inga D. Neumann, Inga D. Neumann, Peter J. Flor, Peter J. Flor, Inga D. Neumann, Grasielle C. Kincheski, Leandro J. Bertoglio, Antonio Pádua Carobrez, Helio Zangrossi, Frederico Guilherme Graeff, James Winslow, Yogita Chudasama, Paul Newhouse, Heather Wilkins, Naheed (Max) Mirza, Shuang Yu, Nuno Sousa, Osborne F. X. Almeida, Osborne F. X. Almeida, Nuno Sousa, Shuang Yu, Osborne F. X. Almeida, Nuno Sousa, Shuang Yu, Tim C. Kirkham, Tim C. Kirkham, Jason C. G. Halford, Ronald F. Mucha, Cecilia J. Hillard, Cecilia J. Hillard, Kim Wolff, Fiona Thomson, Susan Napier, Marie-Louise G. Wadenberg, Craig A. Erickson   +199 more
openaire   +3 more sources

N-acetylcysteine and lipoprotein

The Lancet, 1991
A F, Stalenhoef, A A, Kroon, P N, Demacker   +2 more
openaire   +2 more sources