Results 251 to 260 of about 74,982 (294)
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Chemico-Biological Interactions, 2014
Geldanamycin (GDN) is a benzoquinone ansamycin antibiotic with anti-proliferative activity on tumor cells. GDN cytotoxicity has been attributed to the disruption of heat shock protein 90 (Hsp90) binding and stabilizing client proteins, and by the induction of oxidative stress with concomitant glutathione (GSH) depletion.
Petr, Mlejnek, Petr, Dolezel
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Geldanamycin (GDN) is a benzoquinone ansamycin antibiotic with anti-proliferative activity on tumor cells. GDN cytotoxicity has been attributed to the disruption of heat shock protein 90 (Hsp90) binding and stabilizing client proteins, and by the induction of oxidative stress with concomitant glutathione (GSH) depletion.
Petr, Mlejnek, Petr, Dolezel
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N-acetylcysteine-cysteine disulfide excretion in the urine following N-acetylcysteine administration
The Journal of Pediatrics, 1969Summary Three patients taking N-acetylcysteine asa topical pulmonary mucolytic agent have been shown to excrete in urine the mixed disulfide of this compound with cysteine. The disulfide gives a positive cyanide-nitroprusside test and may be easily confused by paper chromatography with beta-mercaptolactate-cysteine disulfide, a substance excreted in ...
V E, Shih, J D, Schulman
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Hospital Pharmacy, 2004
Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late Phase III trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and ...
Dennis J. Cada +2 more
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Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late Phase III trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and ...
Dennis J. Cada +2 more
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1994
Publisher Summary N-Acetylcysteine (NAC) is a thiol-containing compound that has been used in clinical practice for several years. Historically, NAC was introduced for the treatment of congestive and obstructive lung diseases; primarily those associated with hypersecretion of mucus, for example, chronic bronchitis and cystic fibrosis.
Peter Moldéus, Ian A. Cotgreave
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Publisher Summary N-Acetylcysteine (NAC) is a thiol-containing compound that has been used in clinical practice for several years. Historically, NAC was introduced for the treatment of congestive and obstructive lung diseases; primarily those associated with hypersecretion of mucus, for example, chronic bronchitis and cystic fibrosis.
Peter Moldéus, Ian A. Cotgreave
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Alternative medicine review : a journal of clinical therapeutic, 2000
N-acetylcysteine (NAC) is the acetylated precursor of both the amino acid L-cysteine and reduced glutathione (GSH). Historically it has been used as a mucolytic agent in chronic respiratory illnesses as well as an antidote for hepatotoxicity due to acetaminophen overdose.
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N-acetylcysteine (NAC) is the acetylated precursor of both the amino acid L-cysteine and reduced glutathione (GSH). Historically it has been used as a mucolytic agent in chronic respiratory illnesses as well as an antidote for hepatotoxicity due to acetaminophen overdose.
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N-Acetylcysteine and addiction
Arbor Clinical Nutrition Updates, 2009In a nutshellThe rationale for using N-Acetylcysteine to treat addiction is because it influences glutamate handling in the brain, and an excess of this excitatory neurotransmitter is known to be associated with various forms of addiction.Animal and particularly human clinical trial data is insufficient to allow any definitive conclusion, but this is ...
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