Results 111 to 120 of about 14,739 (167)

Bifunctional Monosaccharides Preferentially Localize to Nuclear Subcompartments. [PDF]

Chembiochem
Barahtjan P, Iglesias-Artola JM, Böhlig K, Lohmann A, Nadler A.   +4 more
europepmc   +1 more source

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Poly(N-acetylgalactosamine) deacetylase

1988
Publisher Summary The poly(N-acetylgalactosamine) [poly(GalNAc)] deacetylase present in A. parasiticus catalyzes the hydrolysis of acetamido groups of poly(GalNAc). A similar enzyme was demonstrated in the extract of N. crassa. The poly(GalNAc) deacctylasc activity is assayed by measuring the radioactivity of [3H]acetic acid liberated from the ...
Y, Araki, E, Ito
openaire   +2 more sources

Two-step enzymatic synthesis of UDP-N-acetylgalactosamine

Bioorganic & Medicinal Chemistry Letters, 2005
UDP-GalNAc has been synthesised with high yield from GalNAc, UTP and ATP using recombinant human GalNAc kinase GK2 and UDP-GalNAc pyrophosphorylase AGX1. Both enzymes have been prepared in one step from 1L cultures of transformed Escherichia coli and the UDP-GalNAc produced has been purified by a simple procedure.
Bourgeaux, V., Piller, F., Piller, V.
openaire   +3 more sources

Stereoselective synthesis of α-C-glycosides of N-acetylgalactosamine

Tetrahedron: Asymmetry, 2000
Abstract Attempts to synthesise α-C-glycosides of N-acetylgalactosamine by selective deprotection at C-2′ of allyl α-C-galactoside 1 and subsequent amination failed, but opened the way to α-C-talopyranosides. The synthesis of α-C-glycosides of N-acetylgalactosamine was performed from allyl α-C-glucopyranoside 9, which was regioselectively deprotected,
CIPOLLA, LAURA FRANCESCA, LA FERLA, BARBARA, Lay, L, PERI, FRANCESCO, NICOTRA, FRANCESCO   +4 more
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N-acetylgalactosamine delivery systems for RNA therapeutics: a patent perspective

Expert Opinion on Therapeutic Patents, 2023
SiRNA molecules with a feature of good gene-silencing are critical for drug discovery and development based on RNA interference. GalNAc-RNA therapeutics is a rapid growing area in RNA therapeutics.This article provides patent landscape and modification feature of GalNAc-RNA therapeutics.
Hai-Long, Zhang, Lansuo, Wang
openaire   +2 more sources

The synthesis of UDP-galactosamine and UDP-N-acetylgalactosamine

Biochemical and Biophysical Research Communications, 1970
Abstract A commercially available preparation of galactose-1-phosphateuridyl transferase was used in the synthesis of UDP-galactosamine and UDP-N-acetylgalactosamine. The method provides a relatively simple means for preparing these important biological materials in high yield and in an isotopic form of almost any desired specific radioactivity ...
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Immunochemical Characterization of Feline and Human N-Acetylgalactosamine 4-Sulfatase

Biochemical Medicine and Metabolic Biology, 1994
Maroteaux-Lamy syndrome (mucopolysaccharidosis type VI; MPS VI) is a disorder which results from a deficiency in the lysosomal associated enzyme N-acetylgalactosamine 4-sulfatase (4-sulfatase). A feline model of human MPS VI has previously been described and provides a system for the evaluation of enzyme replacement therapy protocols.
D A, Brooks, G J, Gibson, J J, Hopwood
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N-acetylgalactosamine Kinase: A Naturally Promiscuous Small Molecule Kinase

Applied Biochemistry and Biotechnology, 2011
N-acetylgalactosamine kinase is a member of the GHMP family of small molecule kinases which catalyses the ATP-dependent phosphorylation of N-acetylgalactosamine. It is highly similar in structure and sequence to galactokinase. Alteration of galactokinase at a key tyrosine residue (Tyr-379 in the human enzyme) has been shown to dramatically enhance the ...
Helena, Kristiansson, David J, Timson
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Purification and properties of human N-acetylgalactosamine-6-sulfate sulfatase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1981
1. Human N-acetylgalactosamine-6-sulfate sulfatase (EC 3.1.6.-) from human placenta has been purified more than 3000-fold by gel filtration, ion-exchange and substrate affinity chromatography. The enzyme has a molecular weight of 90 000 by gel filtration chromatography and 85 000 by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis ...
C T, Lim, A L, Horwitz
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