Results 51 to 60 of about 14,739 (167)

Characterization of dermatan sulfate and chondroitin sulfate profiles during brain regeneration in Styela plicata

The FEBS Journal, EarlyView.
Adult ascidians are capable of regenerating their entire brains following injury, and glycosaminoglycans have been shown to either promote or inhibit neuritogenesis. In this study, dermatan 2,6‐disulfate (D2,6S) was identified as the predominant complex carbohydrate in the ascidian brain.
Taynan Motta Portal, Samara de Oliveira Pimentel, Bruno da Costa Rodrigues, Mauro Sérgio Gonçalves Pavão, Rodrigo Nunes da Fonseca, Cintia Monteiro de Barros   +5 more
wiley   +1 more source

Lectin Histochemical Study of Cell Surface Glycoconjugate in Gastric Carcinoma Using Helix Pomatia Agglutinin [PDF]

Acta Medica Iranica, 2010
"nAltered glycosylation of proteins in cancer cells is one of the main processes responsible for anaplasia, invasion and metastatic potential of neoplastic cells.
Mohammad Reza Arab, Somayeh Salari, Mehrbod Karimi, Hasan Mofidpour   +3 more
doaj   +2 more sources

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

A Novel Pot-Economy Approach to the Synthesis of Triantennary GalNAc-Oligonucleotide

Molecules
N-Acetylgalactosamine (GalNAc) is an efficient and multifunctional delivery tool in the development and synthesis of chemically modified oligonucleotide therapeutics (conjugates).
Artem Evgenievich Gusev, Vladimir Nikolaevich Ivanov, Nikolai Andreevich Dmitriev, Aleksandr Viktorovich Kholstov, Vladislav Aleksandrovich Vasilichin, Ilya Andreevich Kofiadi, Musa Rakhimovich Khaitov   +6 more
doaj   +1 more source

Clinical utility of endurance measures for evaluation of treatment in patients with mucopolysaccharidosis VI (Maroteaux-Lamy syndrome)

Journal of Pediatric Rehabilitation Medicine, 2010
Increased functional capacity of major organ systems improves the quality of life and contributes to reductions in the morbidity associated with chronic debilitating diseases.
Arline McDonald, Robert Steiner, Kerry Kuehl, Sean Turbeville   +3 more
doaj   +1 more source

The Dual Face of Fusobacterium nucleatum in Cancer: Foe, Friend or Both?

Journal of Periodontal Research, EarlyView.
Fusobacterium nucleatum has established interactions with cancers in humans. However, contrary to a traditional view that these interactions are uniformly pro‐tumoural, recent evidence suggests a more nuanced role, where contact‐dependent and contact‐independent mechanisms may support either tumour progression or restriction depending on tumour site ...
Anjali Chander, Huile Lim, Gilad Bachrach, Miguel Reis Ferreira   +3 more
wiley   +1 more source

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, Volume 13, Issue 43, 3 August 2026.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source

ASGR1 Deficiency Promotes Liver Fibrosis by Enhancing Pro‐Inflammatory Arachidonic Acid Metabolism and ALP Secretion

Immunity, Inflammation and Disease, Volume 14, Issue 8, August 2026.
ABSTRACT Background Asialoglycoprotein receptor 1 (ASGR1), a hepatocyte‐specific receptor, represents a potential therapeutic target for hypercholesterolemia. However, liver safety risks of ASGR1‐targeted therapies remain poorly characterized. This study aims to investigate the impact of ASGR1 deficency on liver fibrosis and its underlying mechanisms ...
Hui Zhu, Xin‐ping Huang, Kai You, Yan Chen, Peng‐hui Li, Jia‐wang Tao, Xiao‐rui Yu, Jie‐hui Xu, Guo‐sheng Xu, Yin‐xiong Li   +9 more
wiley   +1 more source

Factor XI Inhibition for Ischemic Stroke Secondary Prevention: Pharmacology, Clinical Evidence, and Future Directions

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Ischemic stroke remains a leading cause of death and disability worldwide, and bleeding (particularly intracranial hemorrhage) continues to limit conventional antithrombotic therapy in secondary prevention, even with direct oral anticoagulants.
Federica Ferrari, Roberto Federico Villa
wiley   +1 more source

Clinical Pharmacology of Eplontersen, the First Approved GalNAc‐Conjugated Antisense Oligonucleotide

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Eplontersen is a GalNAc‐conjugated antisense oligonucleotide (ASO) approved for the treatment of hereditary transthyretin‐mediated amyloidosis with polyneuropathy (ATTRv‐PN). GalNAc conjugation enables targeted hepatic delivery and improved potency compared with unconjugated ASOs.
Rosie Z. Yu, John K. Diep, Xiang Gao, Cecilia Arfvidsson, Angelica Quartino   +4 more
wiley   +1 more source