Specific N-glycans of Hepatocellular Carcinoma Cell Surface and the Abnormal Increase of Core-α-1, 6-fucosylated Triantennary Glycan via N-acetylglucosaminyltransferases-IVa Regulation. [PDF]
Sci Rep, 2015 Glycosylation alterations of cell surface proteins are often observed during the progression of malignancies. The specific cell surface N-glycans were profiled in hepatocellular carcinoma (HCC) with clinical tissues (88 tumor and adjacent normal tissues)
Nie H +11 more
europepmc +5 more sources
Combinatorial Roles of Heparan Sulfate Proteoglycans and Heparan Sulfates in Caenorhabditis elegans Neural Development [PDF]
, 2014 Heparan sulfate proteoglycans (HSPGs) play critical roles in the development and adult physiology of all metazoan organisms. Most of the known molecular interactions of HSPGs are attributed to the structurally highly complex heparan sulfate (HS) glycans.
AN Minniti +41 more
core +14 more sources
N-acetylglucosaminyltransferases and nucleotide sugar transporters form multi-enzyme-multi-transporter assemblies in golgi membranes in vivo. [PDF]
Cell Mol Life Sci, 2019 Branching and processing of N-glycans in the medial-Golgi rely both on the transport of the donor UDP-N-acetylglucosamine (UDP-GlcNAc) to the Golgi lumen by the SLC35A3 nucleotide sugar transporter (NST) as well as on the addition of the GlcNAc residue ...
Khoder-Agha F +6 more
europepmc +3 more sources
Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases [PDF]
, 2020 Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions.
Callewaert, Nico +6 more
core +1 more source
Human T cell glycosylation and implications on immune therapy for cancer [PDF]
, 2020 Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico +3 more
core +1 more source
Targeting MGAT4A-Mediated N-Glycosylation as a Therapeutic Strategy to Inhibit Glioblastoma Stem Cell Invasion. [PDF]
Exploration (Beijing)ABSTRACT Glioblastoma (GBM) is the most aggressive type of primary brain tumor, and its invasive properties contribute significantly to incomplete surgical resection and tumor recurrence. Despite extensive clinical efforts to mitigate GBM invasion, targeted therapies against GBM stem cells (GSCs), which drive invasion, remain incompletely understood ...
Niu R, Liu M, Yang Q, Yin J.
europepmc +2 more sources
The impact of elevation of total bilirubin level and etiology of the liver disease on serum N-glycosylation patterns in mice and men [PDF]
, 2010 The GlycoFibroTest and GlycoCirrhoTest are noninvasive alternatives for liver biopsy that can be used as a follow-up tool for fibrosis patients and to diagnose cirrhotic patients, respectively.
BLOMME, BRAM +5 more
core +1 more source
Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression [PDF]
, 2017 Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial ...
Bacigalupo, Maria Lorena +2 more
core +1 more source
The Role of Glycosyltransferases in Colorectal Cancer [PDF]
, 2021 Colorectal cancer (CRC) is one of the main causes of cancer death in the world. Posttranslational modifications (PTMs) have been extensively studied in malignancies due to its relevance in tumor pathogenesis and therapy.
Aroca Martínez, Gustavo +9 more
core +2 more sources
A Systematic Framework to Derive N-glycan Biosynthesis Process and the Automated Construction of Glycosylation Networks [PDF]
, 2016 published_or_final_versio
Akoi-Kinoshita, K +4 more
core +1 more source