Results 111 to 120 of about 614 (173)
Hemodynamic effects of N-acetylprocainamide in heart disease
Clinical Pharmacology and Therapeutics, 1982 In six normal subjects and 6 patients with primary cardiomyopathy, left ventricular performance was evaluated at rest and during isometric handgrip exercise after 4 days of oral N-acetylprocainamide (NAPA) at each of the three dosage levels (3, 4, 5, and 6 gm/day).
M H, Crawford +5 more
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Age-Related Pharmacokinetics of N-Acetylprocainamide in Rats
Journal of Pharmaceutical Sciences, 1983 The pharmacokinetics of N-acetylprocainamide, administered orally or intravenously, were studied in 3-, 6-, and 12-month-old rats using a two-way crossover study design. At 3, 6, and 12 months of age, the half-life values of N-acetylprocainamide were 1.66, 1.82, and 2.29 hr, respectively; the apparent volumes of distribution were 4.75, 3.35, and 1.98 ...
A, Yacobi +4 more
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Pharmacokinetics of Procainamide and N-Acetylprocainamide in Rats
Journal of Pharmaceutical Sciences, 1981 The pharmacokinetics of distribution and elimination of procainamide and its major metabolite, N-actylprocainamide, were studied in rats. Eight rats were selected randomly, and each received intravenously 14C-labeled procainamide hydrochloride (75 mg/kg) or 14C-labeled N-acetylprocainamide hydrochloride (86 mg/kg) according to a two-way crossover ...
B L, Kamath +4 more
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Comparative antiarrhythmic efficacy of intravenous N-acetylprocainamide and procainamide
European Journal of Clinical Pharmacology, 1979 Ten patients with persistent ventricular arrhythmia were studied in a comparison of the antiarrhythmic efficacy of N-acetylprocainamide (NAPA) and procainamide (PA). Each patient performed three exercise tests for 40 min., on different days, with submaximal and fixed work loads. During the first exercise test no drug was administered.
C, Sonnhag, E, Karlsson
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Intravenous N-acetylprocainamide disposition kinetics in coronary artery disease
Clinical Pharmacology and Therapeutics, 1980 N-Acetylprocainamide (NAPA) disposition kinetics was studied in eight patients with coronary artery disease. NAPA was given over a 45-min period by intravenous infusion, and blood samples were drawn at specified times for 24 hr. NAPA plasma levels were determined by a specific high-pressure liquid chromatography (HPLC) procedure and the concentration ...
R E, Kates +3 more
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N‐acetylprocainamide levels in patients with end‐stage renal failure
Clinical Pharmacology & Therapeutics, 1976 Serum concentrations of pro cain amide (PA) and N‐acetylprocainamide (NAPA) were measured by fluorometry in subjects with normal renal function (n = 4) and in patients with end‐stage renal failure (n = 3) after administration of 6.5 mg/kg of PA · HCI orally.
T P, Gibson, E J, Matusik, W A, Briggs
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Trimethoprim alters the disposition of procainamide and N-acetylprocainamide
Clinical Pharmacology and Therapeutics, 1988 The steady-state pharmacokinetics and pharmacodynamics of procainamide and its active N-acetyl metabolite (NAPA) were assessed alone and in combination with trimethoprim. Eight healthy men received oral sustained-release procainamide, 500 mg every 6 hours for 3 days, alone and with oral trimethoprim, 200 mg daily for 4 days.
T, Kosoglou, M L, Rocci, P H, Vlasses
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Comparative Vagolytic Effects of Procainamide and N- Acetylprocainamide in the Dog
Journal of Cardiovascular Pharmacology, 1983 Procainamide exerts vagolytic effects which are deleterious in clinical therapy for supraventricular arrhythmias. The purpose of the present study was to determine if N-acetylprocainamide (NAPA), an active metabolite of procainamide which has been proposed as an effective and less toxic alternative, would exert an equivalent degree of vagal blockade ...
D L, Pearle, J D, Souza, R A, Gillis
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Effective plasma concentration of N-acetylprocainamide in rats.
Research communications in chemical pathology and pharmacology, 1979 Six groups of rats received saline or N-Acetylprocainamide (NAPA) 2--50 mg/kg, intraperitoneally. Thirty minutes later heart rates were measured and simultaneously a blood sample was withdrawn from each rat. There was a linear relationship between plasma concentrations and the administered doses, suggesting linear pharmacokinetics for NAPA.
A, Yacobi +3 more
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Pharmacokinetics of N-Acetylprocainamide
Angiology, 1986Shortly after Dreyfus and his colleagues demonstrated that procainamide was metabolized by acetylation to N-acetylprocainamide (NAPA), Drayer, Reidenberg and Sevy reported that NAPA had antiarrhythmic activity in an animal model. We confirmed these findings and found that plasma levels of NAPA were high enough to warrant consideration in managing ...
A J, Atkinson, T I, Ruo
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