Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3 [PDF]
Oncogene, 2004 Cell growth is promoted by mitogens and survival factors, which activate intracellular signalling pathways to control cell cycle progression and cellular integrity. Proliferation signals are transmitted through Ras and Rho family small G-proteins coupled to mitogen-activated protein kinase (MAPK) cascades, while survival signals are propagated by lipid-
Li, Li +4 more
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Short Chain N-acyl Homoserine Lactone Production by Soil Isolate Burkholderia sp. Strain A9
Sensors, 2013 In the bacteria kingdom, quorum sensing (QS) is a cell-to-cell communication that relies on the production of and response to specific signaling molecules. In proteobacteria, N-acylhomoserine lactones (AHLs) are the well-studied signaling molecules.
Kok-Gan Chan +4 more
doaj +1 more source
Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target [PDF]
, 2014 YesN-acylhomoserine lactone (AHL)-based quorum sensing (QS) is important for the regulation of proteobacterial virulence determinants. Thus, the inhibition of AHL synthases offers non-antibiotics-based therapeutic potentials against QS-mediated bacterial
A Dürig +46 more
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Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer [PDF]
Journal of Bacteriology, 1995 N-Acylhomoserine lactone (acyl-HSL)-mediated gene expression, also called autoinduction, is conserved among diverse gram-negative bacteria. In the paradigm Vibrio fischeri system, bioluminescence is autoinducible, and the lux operon requires the transcriptional activator LuxR and the acyl-HSL autoinducer for expression.
S, Beck von Bodman, S K, Farrand
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Sensors, 2013 Proteobacteria produce N-acylhomoserine lactones as signaling molecules, which will bind to their cognate receptor and activate quorum sensing-mediated phenotypes in a population-dependent manner.
Cheng-Siang Wong +6 more
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Purification and characterisation of a quorum quenching AHL-lactonase from the endophytic bacterium Enterobacter sp. CS66. [PDF]
, 2018 The quorum quenching (QQ) activity of endophytic bacteria associated with medicinal plants was explored. Extracts of the Gram-negative Enterobacter sp. CS66 possessed potent N-acylhomoserine lactone (AHL) hydrolytic activity in vitro.
Abdelhamid, Yassmin +4 more
core +1 more source
Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis. [PDF]
Appl Environ Microbiol, 2004 Ulrich RL.
europepmc +3 more sources
Molecular Plant-Microbe Interactions, 2004 Many gram-negative bacteria employ N-acylhomoserine lactones (AHL) to regulate diverse physiological processes in concert with cell population density (quorum sensing [QS]).
I. K. Toth +7 more
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Quorum sensing communication between bacteria and human cells: signals, targets, and functions [PDF]
, 2014 Both direct and long-range interactions between pathogenic Pseudomonas aeruginosa bacteria and their eukaryotic hosts are important in the outcome of infections. For cell-to-cell communication, these bacteria employ the quorum sensing (QS) system to pass
Angelika Holm, Elena Vikström
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Attenuated Strains of Pseudomonas aeruginosa: A Promising Cell Factory for Rhamnolipid Production
Microbial Biotechnology, Volume 18, Issue 11, November 2025.PGN strains are generated by the deletion of virulence factor genes. The metabolic pathways and regulatory frameworks that lead to high‐efficiency production of rhamnolipids in P. aeruginosa are preserved in these strains. Therefore, PGN strains are promising bio‐safe cell factories for the industrial production of rhamnolipids.
Parvathy V. Das +3 more
wiley +1 more source