Results 31 to 40 of about 783,982 (246)

N-body simulations of gravitational dynamics

, 2011
We describe the astrophysical and numerical basis of N-body simulations, both of collisional stellar systems (dense star clusters and galactic centres) and collisionless stellar dynamics (galaxies and large-scale structure).
A. Ahmad, A. Brandt, A. Ishibashi, A. King, A. Klypin, A. Lenard, A. Sills, A. Sills, A. Tanikawa, A.V. Kravtsov, B. Lanzoni, B. Moore, B. Moore, C. Dupraz, C. Lajoie, C. Power, C. Theis, C.D. Bailyn, C.D. Bailyn, C.S. Frenk, D. Lynden-Bell, D. Pinchon, D. Sugimoto, D.C. Heggie, D.C. Heggie, D.C. Heggie, D.C. Heggie, D.J. Faulkner, D.J. Price, E. Athanassoula, E. Athanassoula, E. Gaburov, E. Holmberg, E. Kim, E. Kokubo, E. Komatsu, E. Terlevich, E.H. Morgan, F. Combes, F. Hohl, F.I. Cooperstock, G. Efstathiou, G. Efstathiou, G. Lodato, G.D. Quinlan, H. Baumgardt, H. Baumgardt, H. Baumgardt, H. Baumgardt, H. Baumgardt, H. Baumgardt, H. Cheng, H. Cohn, H. Yoshida, H. Yoshida, H.B. Perets, H.C. Plummer, I.A. Bonnell, I.T. Iliev, J. Dubinski, J. Dubinski, J. Heyvaerts, J. Magorrian, J. Magorrian, J. Makino, J. Makino, J. Makino, J. Makino, J. Makino, J. Stadel, J.E. Barnes, J.E. Barnes, J.E. Barnes, J.E. Greene, J.F. Navarro, J.G. Hills, J.K. Salmon, J.M. Fregeau, J.R. Hurley, K. Gebhardt, K. Gebhardt, K. Heitmann, K. Nitadori, K. Takahashi, L. Cullen, L. Greengard, L. Hernquist, L. Hernquist, L. Hernquist, L. Hernquist, M. Clutton-Brock, M. Davis, M. Freitag, M. Giersz, M. Hénon, M. Suzuki, M. Trenti, M. Volonteri, M. Zemp, M.B. Davies, M.D. Weinberg, M.D. Weinberg, M.S. Warren, N.N. Kozlov, P. Bode, P. Hut, P. Hut, P. Hut, P. Kustaanheimo, P. Madau, P. Saha, P. Saha, P.J. Quinn, P.J.E. Peebles, P.P. Ewald, Q. Sheng, R. Balescu, R. Klessen, R. Lynds, R. Spurzem, R. Spurzem, R. Teyssier, R.A. James, R.B. Larson, R.H. Miller, R.P. Church, R.P. Church, S. Chin, S. Ghigna, S. Harfst, S. Harfst, S. Inagaki, S. Mikkola, S. Mikkola, S. Mikkola, S. von Hoerner, S.D.M. White, S.D.M. White, S.D.M. White, S.F. Portegies Zwart, S.F. Portegies Zwart, S.F. Portegies Zwart, S.J. Aarseth, S.J. Aarseth, S.J. Aarseth, S.J. Aarseth, S.L.W. McMillan, T. Buchert, T. Fukushige, T. Holder, T. Ito, T.A. McGlynn, T.M. Éneev, V. Springel, V. Springel, V. Springel, V. Springel, V.F. Mukhanov, W. Dehnen, W. Dehnen, W. Dehnen, W. Priestley, W.D. Elliott, W.E. Harris   +163 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Local stochastic non-Gaussianity and N-body simulations

, 2011
Large-scale clustering of highly biased tracers of large-scale structure has emerged as one of the best observational probes of primordial non-Gaussianity of the local type (i.e. f_{NL}^{local}).
A. Lewis, A. Pillepich, A. Slosar, B. Robertson, B.A. Reid, C.-P. Ma, C.T. Byrnes, D. Babich, E. Komatsu, H.J. Mo, J. Smidt ., J.-Q. Xia ., J.L. Tinker ., J.M. Maldacena, K. Dimopoulos, K. Koyama, K.M. Smith, K.M. Smith, Kendrick M Smith, L. Moscardini, L. Senatore, L. Verde, M. LoVerde, M.S. Warren, Marilena LoVerde, P. Creminelli, P. Creminelli, P. Creminelli, P. Creminelli, P.D. Meerburg, Q.-G. Huang, R. Scoccimarro, S. Cole, S. Matarrese, V. Desjacques, WMAP collaboration, WMAP collaboration, Y. Zeldovich   +37 more
core   +1 more source

Power-law correlation and discreteness in cosmological N-body simulations [PDF]

, 2002
We analyse with simple real-space statistics the Virgo consortium's cosmological N-body simulations. Significant clustering rapidly develops well below the initial mean interparticle separation \Lambda_i, where the gravitational force on a particle is ...
Baertschiger, Thierry, Joyce, Michael, Labini, Francesco Sylos   +2 more
core   +4 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Direct N-body Simulations of Rubble Pile Collisions

, 1999
There is increasing evidence that many km-sized bodies in the Solar System are piles of rubble bound together by gravity. We present results from a project to map the parameter space of collisions between km-sized spherical rubble piles. The results will
Leinhardt, Z. M., Quinn, T., Richardson, D. C.   +2 more
core   +2 more sources

2HOT: An Improved Parallel Hashed Oct-Tree N-Body Algorithm for Cosmological Simulation [PDF]

, 2013
We report on improvements made over the past two decades to our adaptive treecode N-body method (HOT). A mathematical and computational approach to the cosmological N-body problem is described, with performance and scalability measured up to 256k ($2^{18}
Warren, Michael S.
core   +4 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source