Results 21 to 30 of about 13,464,291 (195)

Discovery and In Vitro Characterization of SPL028: Deuterated N,N-Dimethyltryptamine. [PDF]

ACS Med Chem Lett, 2023
The psychedelic N,N- dimethyltryptamine (DMT) is in clinical development for the treatment of major depressive disorder. However, when administered via intravenous infusion, its effects are short-lived due to rapid clearance.
Layzell M, Rands P, Good M, Joel Z, Cousins R, Benway T, James E, Routledge C.   +7 more
europepmc   +3 more sources

Efficacy of N, N-dimethyltryptamine (DMT) psychedelic therapy for substance misuse: A systematic review and meta-analysis. [PDF]

J Psychopharmacol
BACKGROUND: Conventional psychological and pharmacological substance abuse treatments are limited to moderate effect sizes and fail to magnify outcomes when combined.
Wallace LM, Bujor A, Sudre G, Kennedy M, Bahnareanu DE, Mittal K.   +5 more
europepmc   +2 more sources

Neuropharmacology of N,N-dimethyltryptamine [PDF]

Brain Research Bulletin, 2016
N,N-dimethyltryptamine (DMT) is an indole alkaloid widely found in plants and animals. It is best known for producing brief and intense psychedelic effects when ingested. Increasing evidence suggests that endogenous DMT plays important roles for a number of processes in the periphery and central nervous system, and may act as a neurotransmitter.
Theresa M, Carbonaro, Michael B, Gatch
openaire   +2 more sources

Extraction and Characterization of N,N‑Dimethyltryptamine from Mimosa tenuiflora: A Multivariate Approach [PDF]

ACS Omega
Lucas Cordeiro de Oliveira, Taynah Pereira Galdino, Marcelo da Silva Pedro, Mateus Araujo Luz, Igor de Melo Castro, Evilasio Anisio Costa Filho, João Davi da Silva Gonçalves, Antonio Gilson B. Lima, Victor Ignacio Afonso, Marcus Vinicius Lia Fook, Suédina Maria de Lima Silva   +10 more
doaj   +2 more sources

Parapsychology, N, N-Dimethyltryptamine and the Pineal Gland

, 2019
In the last decades, one of the psychedelic substances which has gained high attention for its implications in several para-psychological phenomena (including out-of-body states, deep changes in sensory perception, mood, and thought, travels in" hyperspace", and meetings with disincarnate entities, as well as other" breakthrough experiences") is ...
Bragazzi, Nicola Luigi, Khabbache, Hicham, Perduca, Marco, Neri, Bruno, Firenzuoli, Fabio, Penazzi, Gabriele, Simões, Mário, Zerbetto, Riccardo, Re, Tania Simona   +8 more
openaire   +2 more sources

Proliferative Effects of the Psychedelic N,N-Dimethyltryptamine (DMT) in Human Neural Stem Cells. [PDF]

ACS Chem Neurosci
The serotonergic psychedelic N,N-dimethyltryptamine (DMT) produces rapid antidepressant effects in preclinical and early clinical studies. Therapeutic benefits have been linked to sustained neural plasticity, including adult neurogenesis in rodents ...
Salerno JA, Dominguez ER, Karmirian K, Arrais BABMS, Alves J, Erjautz G, Kroening K, Souza LRQ, Ornelas I, Rehen S.   +9 more
europepmc   +2 more sources

In Vitro Study of the Bioavailability and Bioaccessibility of the Main Compounds Present in Ayahuasca Beverages

Molecules, 2021
Ayahuasca is a psychoactive beverage that contains the psychoactive compound N,N-dimethyltryptamine and β-carboline alkaloids. This study aims at determining in vitro the bioavailability and bioaccessibility of the main compounds present in decoctions of
Joana Gonçalves, Miguel Castilho, Tiago Rosado, Ângelo Luís, José Restolho, Nicolás Fernández, Eugenia Gallardo, Ana Paula Duarte   +7 more
doaj   +1 more source

Concise Synthesis of -Dimethyltryptamine and 5-Methoxy--dimethyltryptamine Starting with Bufotenine from Brazilian ssp

Natural Product Communications, 2015
Bufotenine ( 1 , 5-hydroxy- N,N -dimethyltryptamine) was isolated from seeds of Anadenanthera spp., a tree widespread in the Brazilian cerrado, using an efficient acid-base shakeout protocol. The conversion of bufotenine into N,N -dimethyltryptamine ( 4 )
Leandro A. Moreira, Maria M. Murta, Claudia C. Gatto, Christopher W. Fagg, Maria L. dos Santos   +4 more
doaj   +1 more source

Quantum chemical study of the hydrolysis of oxidized endogenous psychedelic N,N-dimethyltryptamine [PDF]

, 2022
The metabolism of biogenic N,N-dimethyltryptamine (DMT) starts with its enzymatic oxidation to indole-3-N,N-dimethylethaniminium cation (imDMT(+)) by monoamine oxidase (MAO).
Kubicsko, Karoly, Kovacs, Richard D., Farkas, Odon   +2 more
core   +1 more source

A Review of Aeruginascin and Potential Entourage Effect in Hallucinogenic Mushrooms

European Psychiatry, 2022
Introduction The 5-HT2A agonist classic psychedelic, psilocybin (O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine) is a tryptophan, indole-based alkaloid present in up to 2% of certain hallucinogenic “magic” mushroom species; typically Psilocybe azurescens,
P. Chue, A. Andreiev, E. Bucuci, C. Els, J. Chue   +4 more
doaj   +1 more source