Results 1 to 10 of about 1,655 (156)

Mapping the phenomenology of intranasal 5-MeO-DMT in psychedelic-naïve healthy adults [PDF]

Scientific Reports
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring psychedelic tryptamine. Plants containing 5-MeO-DMT have been used throughout history, and in recent years both synthetic and toad-derived 5-MeO-DMT use is being increasingly reported ...
Anna O Ermakova, Raphael Milliere
exaly   +8 more sources

Intensity of Mystical Experiences Occasioned by 5-MeO-DMT and Comparison With a Prior Psilocybin Study [PDF]

Frontiers in Psychology, 2018
5-MeO-DMT is a psychoactive substance found in high concentrations in the bufotoxin of the Colorado River Toad (Bufo alvarius). Emerging evidence suggests that vaporized 5-MeO-DMT may occasion mystical experiences of comparable intensity to those ...
Joseph P Barsuglia, Rafael Lancelotta, Roland R Griffiths   +2 more
exaly   +9 more sources

5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats [PDF]

Scientific Reports, 2023
5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent classical psychedelic known to induce changes in locomotion, behaviour, and sleep in rodents. However, there is limited knowledge regarding its acute neurophysiological effects.
Vítor Lopes-dos-Santos, Sidarta Tg Ribeiro, Richardson N Leao   +2 more
exaly   +10 more sources

Vigilance state dissociation induced by 5-MeO-DMT in mice [PDF]

Communications Biology
Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinct state of vigilance.
Benjamin J. B. Bréant, José Prius Mengual, Alexander Andrews, Anna Hoerder-Suabedissen, Jasmin Patel, David M. Bannerman, Trevor Sharp, Vladyslav V. Vyazovskiy   +7 more
doaj   +6 more sources

A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus [PDF]

Frontiers in Molecular Neuroscience, 2018
The subgranular zone (SGZ) of dentate gyrus (DG) is one of the few regions in which neurogenesis is maintained throughout adulthood. It is believed that newborn neurons in this region encode temporal information about partially overlapping contextual ...
Thiago C Moulin, Lyvia L Petiz, Richardson N Leao   +2 more
exaly   +8 more sources

5-MeO-DMT for post-traumatic stress disorder: a real-world longitudinal case study [PDF]

Frontiers in Psychiatry, 2023
Psychedelic therapy is, arguably, the next frontier in psychiatry. It offers a radical alternative to longstanding, mainstays of treatment, while exciting a paradigm shift in translational science and drug discovery.
Anya Ragnhildstveit, Anya Ragnhildstveit, Ryan Khan, Paul Seli, Paul Seli, Lisa Claire Bass, Lisa Claire Bass, River Jude August, River Jude August, Miriam Kaiyo, Miriam Kaiyo, Nathaniel Barr, Laura Kate Jackson, Michael Santo Gaffrey, Michael Santo Gaffrey, Michael Santo Gaffrey, Joseph Peter Barsuglia, Lynnette Astrid Averill, Lynnette Astrid Averill, Lynnette Astrid Averill   +19 more
doaj   +5 more sources

Cardiac effects of two hallucinogenic natural products, N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyl-tryptamine [PDF]

Scientific Reports
It is unclear whether hallucinogenic tryptamine derivatives namely N,N-dimethyl-tryptamine (DMT) and 5-methoxy-N,N-dimethyl-tryptamine (5-MeO-DMT) exert positive inotropic effects in the human heart.
Joachim Neumann, Tobias Dietrich, Karyna Azatsian, Britt Hofmann, Ulrich Gergs   +4 more
doaj   +4 more sources

Evaluation of the peak experience scale as a rapid assessment tool for the strength of a psychoactive experience with 5-MeO-DMT [PDF]

Frontiers in Psychology
A three-item Peak Experience Scale (PES) was developed to rapidly evaluate the strength of the psychoactive experience, and to guide the dosing regimen, of the psychedelic 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT; mebufotenin).
Johannes T. Reckweg, Natasha L. Mason, Eef L. Theunissen, Claus B. Svendsen, Theis H. Terwey, Johannes G. Ramaekers   +5 more
doaj   +5 more sources

Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. [PDF]

PLoS ONE, 2014
The orphan receptor sigma-1 (sigmar-1) is a transmembrane chaperone protein expressed in both the central nervous system and in immune cells. It has been shown to regulate neuronal differentiation and cell survival, and mediates anti-inflammatory ...
Attila Szabo, Attila Kovacs, Ede Frecska, Eva Rajnavolgyi   +3 more
doaj   +6 more sources

Psychedelics and immunomodulation: Novel approaches and therapeutic opportunities [PDF]

Frontiers in Immunology, 2015
Classical psychedelics are psychoactive substances, which, besides their psychopharmacological activity, have also been shown to exert significant modulatory effects on immune responses by altering signaling pathways involved in inflammation, cellular ...
Attila eSzabo
doaj   +6 more sources