Results 31 to 40 of about 1,655 (156)

Infoveillance and Critical Analysis of the Systematically Reviewed Literature on Dimethyltryptamine and the “God Molecule”

Pharmaceuticals, 2023
Aboriginals of Latin America have used DMT (N,N-dimethyltryptamine) in ritualistic ceremonies for centuries. Nevertheless, there are limited data on web users’ interest concerning DMT.
Ahmed Al-Imam, Marek A. Motyka, Beata Hoffmann, Anita Magowska, Michal Michalak   +4 more
doaj   +1 more source

Sleep-like state during wakefulness induced by psychedelic 5-MeO-DMT in mice

, 2022
AbstractPsychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinct state of arousal. Here, we performed chronic electrophysiological recordings from the cortex concomitant with pupillometry in freely moving ...
Bréant BJB, Mengual JP, Hoerder-Suabedissen A, Patel J, Bannerman DM, Sharp T, Vyazovskiy VV.   +6 more
europepmc   +2 more sources

Reactivations after 5-methoxy-N,N-dimethyltryptamine use in naturalistic settings: An initial exploratory analysis of the phenomenon’s predictors and its emotional valence

Frontiers in Psychiatry, 2022
BackgroundThe psychedelic 5-MeO-DMT has shown clinical potential due to its short duration and ability to induce mystical experiences. However, a phenomenon known as “reactivations” (similar to “flashbacks”) is a poorly understood and frequently reported
Ana María Ortiz Bernal, Charles L. Raison, Rafael L. Lancelotta, Alan K. Davis, Alan K. Davis   +4 more
doaj   +1 more source

A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N,N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers

European Psychiatry, 2022
Introduction 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects. Prospective studies for other tryptamines have suggested beneficial effects on mental health outcomes ...
J. Reckweg, N. Mason, C. Van Leeuwen, S. Tönnes, T. Terwey, J. Ramaekers   +5 more
doaj   +1 more source

Innovative Psychedelic Therapies: Harnessing 5-MeO-DMT and DMT for Mental Health Treatment. [PDF]

ACS Med Chem Lett
Recent advancements in the therapeutic use of psychedelic compounds, particularly 5-MeO-DMT and DMT, have demonstrated significant potential in treating various mental health disorders. This Patent Highlight evaluates findings from multiple recent patents that explore novel applications of these compounds, including their use in severe psychiatric ...
Kargbo RB.
europepmc   +3 more sources

We Licked the Toads so You Don't Have to: A Comprehensive Analysis of the Chemical Syntheses of the Classical Psychedelics Bufotenin(e) and 5-Methoxy-N,N-Dimethyltryptamine. [PDF]

ChemMedChem
The psychedelics 5‐MeO‐DMT and bufotenin—famously secreted by some toads—have been made in many different ways since 1936. Bufotenin (also spelt as bufotenine) and its methylated derivative, 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT), are potent psychedelics that are found in many plants but also excreted by some species of toads.
Homon A, Laramie J, Hayward JJ, Trant JF.   +3 more
europepmc   +2 more sources

Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties. [PDF]

Mol Psychiatry
AbstractRecent studies have sparked renewed interest in the therapeutic potential of psychedelics for treating depression and other mental health conditions. Simultaneously, the novel psychoactive substances (NPS) phenomenon, with a huge number of NPS emerging constantly, has changed remarkably the illicit drug market, being their scientific evaluation
Puigseslloses P, Nadal-Gratacós N, Ketsela G, Weiss N, Berzosa X, Estrada-Tejedor R, Islam MN, Holy M, Niello M, Pubill D, Camarasa J, Escubedo E, Sitte HH, López-Arnau R.   +13 more
europepmc   +4 more sources

2,5-Dimethylbufotenine and 2,5-dimethylbufotenidine: novel derivatives of natural tryptamines found in Bufo alvarius toads

Acta Crystallographica Section E: Crystallographic Communications, 2021
The solid-state structure of the bufotenine derivative bis(5-methoxy-2,N,N-trimethyltryptammonium) (5-MeO-2-Me-DMT) fumarate (systematic name: bis{[2-(5-methoxy-2-methyl-1H-indol-3-yl)ethyl]dimethylazanium} (2E)-but-2-enedioate), 2C14H21N2O+·C4H2O42 ...
Duyen N. K. Pham, Andrew R. Chadeayne, James A. Golen, David R. Manke   +3 more
doaj   +1 more source

Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. [PDF]

Sci Rep, 2017
Abstract Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional Amerindian medicine recently associated with cognitive gains, antidepressant effects, and changes in brain areas related to attention.
Dakic V, Minardi Nascimento J, Costa Sartore R, Maciel RM, de Araujo DB, Ribeiro S, Martins-de-Souza D, Rehen SK.   +7 more
europepmc   +5 more sources

Novel Thermosensitive and Mucoadhesive Nasal Hydrogel Containing 5-MeO-DMT Optimized Using Box-Behnken Experimental Design. [PDF]

Polymers (Basel)
We present the development and characterization of a nasal drug delivery system comprised of a thermosensitive mucoadhesive hydrogel based on a mixture of the polymers Poloxamer 407, Poloxamer 188 and Hydroxypropyl-methylcellulose, and the psychedelic drug 5-methoxy-N,-N-dimethyltryptamine.
Miranda P, Castro A, Díaz P, Minini L, Ferraro F, Paulsen E, Faccio R, Pardo H.   +7 more
europepmc   +3 more sources