Results 21 to 30 of about 1,655 (156)

Short-term safety and tolerability profile of 5-methoxy-N,N-dimethyltryptamine in human subjects: a systematic review of clinical trials [PDF]

Frontiers in Psychiatry
IntroductionPsychedelic agents have regained the attention of pharmaceutical companies as promising treatments for depressive episodes. 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), an atypical psychedelic, is emerging as a potentially effective, novel ...
Aleksander Kwaśny, Alina Wilkowska, Wiesław Jerzy Cubała   +2 more
doaj   +3 more sources

Use of Benefit Enhancement Strategies among 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) Users: Associations with Mystical, Challenging, and Enduring Effects [PDF]

Journal of Psychoactive Drugs, 2020
Rafael Lancelotta, Alan K Davis
exaly   +2 more sources

5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice. [PDF]

Neuropsychopharmacology, 2023
Serotonergic psychedelics are gaining increasing interest as potential therapeutics for a range of mental illnesses. Compounds with short-lived subjective effects may be clinically useful because dosing time would be reduced, which may improve patient access.
Jefferson SJ, Gregg I, Dibbs M, Liao C, Wu H, Davoudian PA, Woodburn SC, Wehrle PH, Sprouse JS, Sherwood AM, Kaye AP, Pittenger C, Kwan AC.   +12 more
europepmc   +3 more sources

5-MeO-DMT: Potential Use of Psychedelic-Induced Experiences in the Treatment of Psychological Disorders. [PDF]

ACS Med Chem Lett, 2021
Kargbo RB.
europepmc   +4 more sources

The epidemiology of 5-methoxy- N, N -dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption [PDF]

Journal of Psychopharmacology, 2018
Alan K Davis, Joseph P Barsuglia, Rafael Lancelotta   +2 more
exaly   +2 more sources

Corrigendum: A Single Dose of 5-MeO-DMT Stimulates Cell Proliferation, Neuronal Survivability, Morphological and Functional Changes in Adult Mice Ventral Dentate Gyrus [PDF]

Frontiers in Molecular Neuroscience, 2019
Rafael Vitor Lima da Cruz, Thiago C. Moulin, Lyvia Lintzmaier Petiz, Richardson N. Leão, Richardson N. Leão   +4 more
doaj   +2 more sources

Molecular Docking, MM-GBSA, and Molecular Dynamics Approach: 5-MeO-DMT Analogues as Potential Antidepressants. [PDF]

Arch Razi Inst, 2023
Since depression is a common mental illness affecting an estimated 5% of people worldwide, investigators are encouraged to develop effective antidepressants. According to the monoamine-deficiency hypothesis, the underlying pathophysiology of depression is a deficiency of some neurotransmitters (serotonin, norepinephrine, or dopamine) in the central ...
Kalirajan R, Rishabh K, Srikanth J, Niharika M, Preeya N, Rezaul I.   +5 more
europepmc   +2 more sources

Author Correction: 5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats [PDF]

Scientific Reports
Annie C. Souza, Bryan C. Souza, Arthur França, Marzieh Moradi, Nicholy C. Souza, Katarina E. Leão, Adriano B. L. Tort, Richardson N. Leão, Vítor Lopes-dos-Santos, Sidarta Ribeiro   +9 more
doaj   +2 more sources

A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms [PDF]

Psychopharmacology, 2019
Malin V Uthaug, Rafael Lancelotta, Kim P. C. Kuypers   +2 more
exaly   +2 more sources

A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers

Frontiers in Pharmacology, 2021
5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects. Prospective studies for other tryptamines have suggested beneficial effects on mental health outcomes.
Johannes Reckweg, Natasha L. Mason, Cees van Leeuwen, Stefan W. Toennes, Theis H. Terwey, Johannes G. Ramaekers   +5 more
doaj   +1 more source