Results 11 to 20 of about 1,655 (156)

Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness. [PDF]

Neurosci Conscious
5-MeO-DMT is a short-acting psychedelic that is anecdotally reported to induce a radical disruption of the self and a paradoxical quality of aroused, waking awareness that is nevertheless devoid of any specific perceptual contents.
Timmermann C, Sanders JW, Reydellet D, Barba T, Luan LX, Angona ÓS, Ona G, Allocca G, Smith CH, Daily ZG, Mason NL, Kloft-Heller L, Kuchar M, Janeckova L, Palenicek T, Erritzoe D, Ramaekers JG, Carhart-Harris RL, Uthaug MV.   +18 more
europepmc   +8 more sources

Complex slow waves in the human brain under 5-MeO-DMT [PDF]

Cell Reports
Summary: 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic drug known for its uniquely profound effects on consciousness; however, it remains unknown how it affects the brain.
George Blackburne, Rosalind G. McAlpine, Marco Fabus, Alberto Liardi, Sunjeev K. Kamboj, Pedro A.M. Mediano, Jeremy I. Skipper   +6 more
doaj   +4 more sources

A narrative synthesis of research with 5-MeO-DMT [PDF]

Journal of Psychopharmacology, 2022
Background: 5-Methoxy- N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring, short-acting psychedelic tryptamine, produced by a variety of plant and animal species. Plants containing 5-MeO-DMT have been used throughout history for ritual and spiritual purposes.
Anna O Ermakova, James J Rucker, Matthew W Johnson   +2 more
exaly   +4 more sources

Synthesis and Characterization of 5‑MeO-DMT Succinate for Clinical Use [PDF]

ACS Omega, 2020
To support clinical use, a multigram-scale process has been developed to provide 5-MeO-DMT, a psychedelic natural product found in the parotid gland secretions of the toad, Incilius alvarius. Several synthetic routes were initially explored, and the selected process featured an optimized Fischer indole reaction to 5-MeO-DMT freebase in high-yield, from
Alexander M. Sherwood, Romain Claveau, Rafael Lancelotta, Kristi W. Kaylo, Kelsey Lenoch   +4 more
doaj   +5 more sources

The clinical pharmacology and potential therapeutic applications of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) [PDF]

Journal of Neurochemistry, 2022
Abstract5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) is a naturally occurring tryptamine that primarily acts as an agonist at the 5‐HT1A and 5‐HT2A receptors, whereby affinity for the 5‐HT1A subtype is highest. Subjective effects following 5‐MeO‐DMT administration include distortions in auditory and time perception, amplification of emotional states ...
J T Reckweg, Malin V Uthaug, Attila Szabo   +2 more
exaly   +6 more sources

Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor [PDF]

Psychopharmacology, 2012
Ayahuasca is a psychoactive tea prepared from a combination of plants that contain a hallucinogenic tryptamine and monoamine oxidase inhibitors (MAOIs). Behavioral pattern monitor (BPM) experiments demonstrated that the combination of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and a behaviorally inactive dose of an MAO(A) inhibitor such as harmaline ...
Adam L Halberstadt, Mark A Geyer, David E Nichols   +2 more
exaly   +5 more sources

The Exploration of Naturalistically used Ayahuasca and 5-MeO-DMT:An assessment of their respective Sub-acute and Long-Term effects on Mental Health Related Variables [PDF]

, 2020
The research summarized in this doctoral dissertation sought to investigate the effects of both ayahuasca and 5-MeO-DMT on mental health-related variables such as affect (depression, anxiety and stress), mindfulness related capacities (observing ...
Uthaug, Malin Vedøy
core   +5 more sources

Ayahuasca and Its Main Component N,N-Dimethyltryptamine (DMT) for the Treatment of Mental Disorders: Mechanisms of Action, Clinical Studies, and Tools to Explore the Human Mind [PDF]

Biomedicines
In recent years, psychopharmacology has experienced a significant challenge, highlighting a renewed and strong scientific interest in psychedelics as breakthrough therapies for mental disorders.
Alice Melani, Giorgia Papini, Marco Bonaso, Letizia Biso, Shivakumar Kolachalam, Nicola Luigi Bragazzi, Ciro Conversano, Graziella Orrù, Biancamaria Longoni, Marco Scarselli   +9 more
doaj   +2 more sources

Diet and chemical defenses of the Sonoran Desert toad. [PDF]

PLoS ONE
The Sonoran Desert toad (Incilius alvarius) is the only animal known to secrete the psychedelic compound 5-MeO-DMT as a chemical defense, but the source of 5-MeO-DMT in I. alvarius remains unknown.
Marina D Luccioni, Jules T Wyman, Edgard O Espinoza, Lauren A O'Connell   +3 more
doaj   +2 more sources

Structural Pharmacology of Bufotenine Derivatives in Activating the 5-HT1A Receptor for Therapeutic Potential in Depression and Anxiety [PDF]

Research
The 5-HT1A receptor is a critical target in the treatment of depression and anxiety. Bufotenine derivatives, such as 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), 5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT), and 5-hydroxy-N,N,N-dimethyltryptamine—derived
Shu-jie Li, Qing-ning Yuan, Wen-yuan Wu, Zhi-han Chen, Duo Chen, Hong Shan, Qin-yu Chu, Wen Hu, Kai Wu, Tao Liu, Yu-yu Zhu, Li Hou, Jing Zhou, Jia Duan, Jin-ao Duan, H. Eric Xu, Hong-yue Ma   +16 more
doaj   +2 more sources