Results 41 to 50 of about 1,655 (156)

Recreational use, analysis and toxicity of tryptamines [PDF]

open access: yes, 2015
The definition New psychoactive substances (NPS) refers to emerging drugs whose chemical structures are similar to other psychoactive compounds but not identical, representing a "legal" alternative to internationally controlled drugs.
Mannocchi, Giulio   +3 more
core   +1 more source

Editorial: Beyond psilocybin: exploring the clinical potential of alternative and novel psychedelics [PDF]

open access: yesFrontiers in Psychiatry
Martin L. Williams   +6 more
doaj   +2 more sources

Development of a mechanism-based pharmacokinetic/pharmacodynamic model to characterize the thermoregulatory effects of serotonergic drugs in mice

open access: yesActa Pharmaceutica Sinica B, 2016
We have shown recently that concurrent harmaline, a monoamine oxidase-A inhibitor (MAOI), potentiates serotonin (5-HT) receptor agonist 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT)-induced hyperthermia.
Xi-Ling Jiang   +4 more
doaj   +1 more source

Examining the Potential Synergistic Effects Between Mindfulness Training and Psychedelic-Assisted Therapy

open access: yesFrontiers in Psychiatry, 2021
Mindfulness-based interventions and psychedelic-assisted therapy have been experimentally utilised in recent years as alternative treatments for various psychopathologies with moderate to great success.
Maria Eleni Eleftheriou, Emily Thomas
doaj   +1 more source

5-Methoxy-N,N-dimethyltryptamine`s pharmacokinetics and viable routes of synthetization [PDF]

open access: yes, 2022
Hallusinogene stoffer har alltid vært en del av naturen på en eller annen måte, og nye blir ofte oppdaget og klassifisert. Blant disse forbindelsene er et hallusinogent tryptamin som finnes i et bredt spekter av plantearter, i tillegg til at det skilles ...
Forner, Emil
core  

A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy-N,N-dimethyltryptamine formulation (GH001) in patients with treatment-resistant depression

open access: yesFrontiers in Psychiatry, 2023
BackgroundTreatment-resistant depression (TRD) is a substantial public health burden, but current treatments have limited effectiveness. The aim was to investigate the safety and potential antidepressant effects of the serotonergic psychedelic drug 5-MeO-
Johannes T. Reckweg   +8 more
doaj   +1 more source

The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [PDF]

open access: yes, 2018
Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of
Erowid, Earth   +6 more
core   +2 more sources

This is your brain on death: a comparative analysis of a near-death experience and subsequent 5-Methoxy-DMT experience

open access: yesFrontiers in Psychology, 2023
IntroductionMuch research has focused on the modeling of the near-death experience (NDE) by classical and atypical psychedelics; however, to date, no study has reported on the relationship between the NDE and the experience induced by the highly potent ...
Pascal Michael   +3 more
doaj   +1 more source

Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists. [PDF]

open access: yesACS Med Chem Lett
Herein, we report the synthesis and characterization of a novel set of substituted indazole-ethanamines and indazole-tetrahydropyridines as potent serotonin receptor subtype 2 (5-HT2) agonists. Specifically, we examine the 5-HT2 pharmacology of the direct indazole analogs of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and related serotonergic ...
Jayakodiarachchi N   +9 more
europepmc   +3 more sources

Proposal of 5-methoxy-N-methyl-N-isopropyltryptamine consumption biomarkers through identification of in vivo metabolites from mice [PDF]

open access: yes, 2017
New psychoactive substances (NPS) are a new breed of synthetically produced substances designed to mimic the effects of traditional illegal drugs. Synthetic cannabinoids and synthetic cathinones are the two most common groups, which try to mimic the ...
Barneo-Muñoz, Manuela   +5 more
core   +2 more sources

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