Results 41 to 50 of about 11,769,643 (158)

The Exploration of Naturalistically used Ayahuasca and 5-MeO-DMT [PDF]

, 2020
The research summarized in this doctoral dissertation sought to investigate the effects of both ayahuasca and 5-MeO-DMT on mental health-related variables such as affect (depression, anxiety and stress), mindfulness related capacities (observing, describing, awareness, non-judgement, and non-reactance), empathy, creativity, and subjective well-being ...
openaire   +2 more sources

1H Nuclear Magnetic Resonance: A Future Approach to the Metabolic Profiling of Psychedelics in Human Biofluids?

Frontiers in Psychiatry, 2021
While psychedelics may have therapeutic potential for treating mental health disorders such as depression, further research is needed to better understand their biological effects and mechanisms of action when considering the development of future novel ...
Sylvana Vilca-Melendez, Malin V. Uthaug, Malin V. Uthaug, Julian L. Griffin   +3 more
doaj   +1 more source

Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties. [PDF]

Mol Psychiatry
AbstractRecent studies have sparked renewed interest in the therapeutic potential of psychedelics for treating depression and other mental health conditions. Simultaneously, the novel psychoactive substances (NPS) phenomenon, with a huge number of NPS emerging constantly, has changed remarkably the illicit drug market, being their scientific evaluation
Puigseslloses P, Nadal-Gratacós N, Ketsela G, Weiss N, Berzosa X, Estrada-Tejedor R, Islam MN, Holy M, Niello M, Pubill D, Camarasa J, Escubedo E, Sitte HH, López-Arnau R.   +13 more
europepmc   +4 more sources

We Licked the Toads so You Don't Have to: A Comprehensive Analysis of the Chemical Syntheses of the Classical Psychedelics Bufotenin(e) and 5-Methoxy-N,N-Dimethyltryptamine. [PDF]

ChemMedChem
The psychedelics 5‐MeO‐DMT and bufotenin—famously secreted by some toads—have been made in many different ways since 1936. Bufotenin (also spelt as bufotenine) and its methylated derivative, 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT), are potent psychedelics that are found in many plants but also excreted by some species of toads.
Homon A, Laramie J, Hayward JJ, Trant JF.   +3 more
europepmc   +2 more sources

Evaluation of neuronal activity in mice treated with 5-MeO-DMT

, 2023
This course completion work verified how 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) can affect neuronal activity in the ventral hippocampus, a brain region related to anxiety.
Lima, Margareth de Brito Nogueira
core  

Cardiac effects of two hallucinogenic natural products, N,N-dimethyl-tryptamine and 5-methoxy-N,N-dimethyl-tryptamine

Scientific Reports
It is unclear whether hallucinogenic tryptamine derivatives namely N,N-dimethyl-tryptamine (DMT) and 5-methoxy-N,N-dimethyl-tryptamine (5-MeO-DMT) exert positive inotropic effects in the human heart.
Joachim Neumann, Tobias Dietrich, Karyna Azatsian, Britt Hofmann, Ulrich Gergs   +4 more
doaj   +1 more source

Psychedelics: Alternative and Potential Therapeutic Options for Treating Mood and Anxiety Disorders

Molecules, 2022
The word “psychedelic” (psyche (i.e., the mind or soul) and delos (i.e., to show)) has Greek origin and was first coined by psychiatrist Humphry Osmond in 1956, who had been conducting research on lysergic acid diethylamide (LSD) at the time. Psychedelic
Henry Lowe, Ngeh Toyang, Blair Steele, Justin Grant, Amza Ali, Lorenzo Gordon, Wilfred Ngwa   +6 more
doaj   +1 more source

Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists. [PDF]

ACS Med Chem Lett
Herein, we report the synthesis and characterization of a novel set of substituted indazole-ethanamines and indazole-tetrahydropyridines as potent serotonin receptor subtype 2 (5-HT2) agonists. Specifically, we examine the 5-HT2 pharmacology of the direct indazole analogs of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and related serotonergic ...
Jayakodiarachchi N, Maurer MA, Schultz DC, Dodd CJ, Thompson Gray A, Cho HP, Boutaud O, Jones CK, Lindsley CW, Bender AM.   +9 more
europepmc   +3 more sources

Craving and personal functioning as mediators of extended‐release buprenorphine efficacy: A four‐way decomposition analysis from a randomised trial

Addiction, EarlyView.
Abstract Aims To investigate whether the treatment effect of extended‐release buprenorphine (BUP‐XR) on opioid‐free days in opioid use disorder (OUD) is mediated by reductions in opioid craving and improvements in personal functioning. Design and setting Exploratory causal mediation analysis using VanderWeele's four‐way decomposition framework in a 24 ...
John Marsden, Mike Kelleher, Fiona Cowden, Edward Day, Jonathan Dewhurst, Rachel Evans, Eilish Gilvarry, Natalie Lowry, Luke Mitcheson, Robert Murray, Sophie Quarshie, Zoë Hoare   +11 more
wiley   +1 more source

The psychedelic afterglow phenomenon: a systematic review of subacute effects of classic serotonergic psychedelics

Therapeutic Advances in Psychopharmacology, 2023
Background: Classic serotonergic psychedelics have anecdotally been reported to show a characteristic pattern of subacute effects that persist after the acute effects of the substance have subsided.
Ricarda Evens, Marianna Elisa Schmidt, Tomislav Majić, Timo Torsten Schmidt   +3 more
doaj   +1 more source