Results 11 to 20 of about 3,710 (138)

T cell response to N-formylated peptides in humans [PDF]

European Journal of Immunology, 2001
We present the first evidence of a T lymphocyte response to N-formylated peptides in humans. N-formylated peptide sequences from self (mitochondrial) and foreign (microbial) antigens were used to isolate antigen-specific T cell clones from healthy individuals, including a set of monozygotic twins.
RISTORI, GIOVANNI, MONTESPERELLI C, FIORILLO, Maria Teresa, BATTISTINI L, CHERSI A, SORRENTINO, Rosa, BORSELLINO G, PERNA A, TRAMONTI D, CANNONI S, PERRONE MP, GIUBILEI, Franco, RICCIO P, SALVETTI, Marco, BUTTINELLI, Carla   +14 more
openaire   +3 more sources

Synthesis of Six Natural Products Enabled by Selective Hydroxylation of Orcinaldehyde‐Like Substrates With an Enzyme Library

Angewandte Chemie International Edition, EarlyView.
Achieving selective (sp3)C–H hydroxylation can streamline the synthesis of complex organic molecules. Biocatalysis presents an opportunity to realize this transformation, however, identifying useful enzymes that enable synthetic strategies can be a challenge due to limitations in enzyme substrate scope.
Gonzalo J. Villegas Rodríguez, Evan O. Romero, Jonathan C. Perkins, Diego N. Rojas, Maximilian S. Hrigora, Alison R. H. Narayan   +5 more
wiley   +1 more source

Enabling Cross‐Coupling Reactivity of α‐Pentafluorosulfanyl Compounds with a Thermally Stable Organozinc α‐SF5 Reagent

Chemistry – A European Journal, EarlyView.
This work describes the first example of a thermally stable α‐SF5 organometallic reagent, which allows for extensive downstream functionalization by allylation and acylation reactions under copper catalysis, as well as palladium‐catalyzed Negishi‐type cross‐coupling conditions up to 96% yield. In silico analysis shines initial light on the requirements
Lujie Xu, David Rombach
wiley   +1 more source

Dual Genotoxic and Antigenotoxic Effects of 3‐Benzoylcoumarins in Mammalian Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Coumarins are phenolic compounds widely recognized for their diverse pharmacological activities and have attracted increasing attention as potential chemopreventive agents. In the present study, four known 3‐benzoylcoumarin derivatives [(1), (2), (3), and (4)] were evaluated for their cytotoxic, mutagenic, and antigenotoxic effects in Chinese ...
Leticia Helena Parreira, Evelyn Pinheiro de Mendonça, Aléxia Polo Siqueira, Cleydson Finotti Cordeiro, Elkin José Torres Sierra, Rudy Bonfilio, Diogo Teixeira Carvalho, Pollyanna Francielli de Oliveira   +7 more
wiley   +1 more source

Selective Hydrogenation of Formamide to Methanol Over Supported Platinum Catalysts

Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.
Amine–CO2 adducts can be hydrogenated to formamides and subsequently to methanol under mild conditions (<150°C), establishing an integrated CO2 capture‐and‐conversion route in a heterogeneous system that directly links amine sorbent cycling with methanol synthesis.
Xuetao Qin, XinXin Tian, Shou Qiu, Han Yan, Haijun Jiao, Henrik Junge, Matthias Beller   +6 more
wiley   +2 more sources

Unspecific Molecular Adsorption (UMA) Sample Preparation Method for Bottom‐up and Whole Protein Analysis: The Foundation

PROTEOMICS, EarlyView.
ABSTRACT The protein sample preparation methods for shotgun proteomics are nowadays well‐established unlike the ones for whole protein analysis. The goal of my work has been to create a simple methodology which provides a single uncomplicated sample preparation tool for these two fields. Nowadays the bulk of proteomics work is done using detergents for
Alexandre Zougman
wiley   +1 more source

Assessing Vancomycin‐Formyl Peptide Conjugate Binding to the Surface of Resistant Staphylococcus aureus via Flow Cytometry

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
A flow cytometry technique was developed to measure the binding of vancomycin‐formyl peptide conjugates to the surface of resistant Staphylococcus aureus. Binding results indicate that the labelling site of the vancomycin targeting element has a major effect on binding to the bacterial cell wall, which correlates with reduced antibiotic activity ...
Winfrey P. Y. Hoo, Jemma Gullick, Ryan F. Leung, Alex J. Fulcher, Rachel W. Cass, Julien Tailhades, Anton Y. Peleg, Jennifer A. E. Payne, Meredith O’Keeffe, Max J. Cryle   +9 more
wiley   +1 more source

Low‐Power NIR‐II Excitable Organic Phototheranostic Agents With NIR‐IIb Emission for Precise Cancer Theranostics

Aggregate, Volume 7, Issue 8, August 2026.
The noncovalent conformational locks (NoCLs) strategy modulates molecular aggregation to synergistically enhance NIR‐II absorption, NIR‐IIb emission, and photothermal conversion efficiency (PCE). QCF NPs incorporating both S···O and S···N NoCLs achieve concurrent NIR‐IIb emission (1550 nm) and PCE (75%) under low‐power 1064 nm excitation, establishing ...
Xin Chen, Yifan Wu, Yutao Hu, Lina Feng, Renmanduhu Sha, Guoyu Jiang, Ben Zhong Tang, Jianguo Wang   +7 more
wiley   +1 more source

Synthesis of N‐Benzyl o‐Methoxy Phase I Metabolites for Use as Liquid Chromatography‐Quadrupole Time of Flight Standards

ChemistrySelect, Volume 11, Issue 30, 10 August 2026.
A novel synthetic method for three phase I o‐desmethyl NBOMe metabolites bromo‐ (3a) and iodo‐ (13b) and chloro‐ analogue (13c) was developed. LC‐QToF analysis confirmed that the synthetic standards matched the major peaks observed in urine sample screens for each of the respective halogen‐substituted metabolites indicating that the synthesised ...
Jordan Spangler, Martin R. Johnston, Peter Stockham   +2 more
wiley   +1 more source

Finding the Perfect Match: Investigation of 1,2‐Diketone‐Based Materials for Use as Cathode Active Material in Rechargeable Magnesium Batteries

Small, Volume 22, Issue 46, 18 August 2026.
A novel and generally applicable early screening method for 1,2‐diketones via cyclic voltammetry and DFT computations identifies phenanthrenequinone as a suitable candidate as cathode active material for use in RMB. Its successful incorporation into a polymer enabled promising lithium and magnesium battery performance.
Noushine Dorrani, Hendrik Koger, Ingo Krossing, Daniel B. Werz   +3 more
wiley   +1 more source