Results 21 to 30 of about 3,710 (138)

Design and Synthesis of Novel Isoflavene TANK‐Binding Kinase 1 Inhibitors With Anti‐Inflammatory Activity

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
TANK‐binding kinase 1 (TBK1) is a key regulator of innate immune signalling and an emerging therapeutic target. Here, we report the design, synthesis, and biological evaluation of isoflavonoid TBK1‐modulating analogues, achieving a sixfold enhancement in inhibition of TBK1 signalling relative to the clinically relevant idronoxil (IDX) parent scaffold ...
Valerio Falasca, W. Samantha N. Jayasekara, Dominic De Nardo, Daniel S. Wenholz, Michael P. Gantier, Naresh Kumar   +5 more
wiley   +1 more source

Design, Synthesis, and Photophysical Studies of Functionalized Polyaromatic Isonitriles as Visible Light Photoredox Catalysts

European Journal of Organic Chemistry, Volume 29, Issue 25, 4 July 2026.
A new series of structurally rich polyaromatic isonitriles is presented as photoredox catalysts. Their photophysical properties are investigated by UV–Vis absorption and fluorescence measurements, combined with experimental and theoretical studies to evaluate both ground‐ and excited‐state redox properties.
Cristina Martini, Camilla Russo, Jussara Amato, Carmine Volpe, Francesca Brunelli, Laurence Grimaud, Maxime R. Vitale, Greta Donati, Andrea Basso, Mariateresa Giustiniano   +9 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, Volume 16, Issue 7, Page 1387-1399, July 2026.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Beyond Descriptor‐Based AI Design: Sp2‐Hybridized Branched Side Chains Enable Pre‐Aggregation–Driven Seeding Effects in Green‐Solvent‐Processed Organic Solar Cells

Advanced Energy Materials, Volume 16, Issue 26, 8 July 2026.
sp2‐hybridized branched side chains are introduced as a new molecular design for NFAs, YBOV, inducing strong solution‐state pre‐aggregation. This pre‐aggregation enables universal seeding motifs, highly ordered film growth, and overcoming the intrinsic current–voltage trade‐off, achieving 19.67% efficiency via green‐solvent processing beyond descriptor‐
Seokhwan Jeong, Donghoo Won, Zhe Sun, Chihyung Lee, Jaewook Kim, Seunglok Lee, Sangjin Yang, Jieun Kim, Keonho Yoon, Dong Young Kim, Yongjoon Cho, Seung‐Jae Shin, Hee‐Seung Lee, Doo‐Hyun Ko, Changduk Yang   +14 more
wiley   +1 more source

Synthesis of Aromatic Aldehydes by CH Formylation of Aromatics with Silyl Formates Prepared from CO2 and Hydrosilanes

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
A new method has been developed for the C–H formylation of aromatic compounds using silyl formates synthesized from CO2 and hydrosilanes. This is the first report on the direct C–H formylation of aromatics with silyl formates. The formylation reactions were promoted by BBr3 or BCl3. The reaction mechanism has been clarified by DFT calculations. Despite
Natsumi Nitta, Kei Hirokawa, So Saibara, Bikash Dev Nath, Kazuto Takaishi, Tadashi Ema   +5 more
wiley   +1 more source

Revisiting Hydrazine Moiety as a Scaffold for the Synthesis of Potential Antiviral Pyrazole Ribonucleoside Analogues

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Three series of pyrazole ribonucleoside analogues were designed and synthesized. They were evaluated, along with some of their pronucleotides, for their antiviral activity against RNA viruses. Pyrazole ribonucleoside analogues were prepared via a linear approach starting with the reaction of D‐ribosylhydrazine with 1,3‐dicarbonyl or acrylonitrile ...
Anaïs Guillou, Nathalie Gros, Delphine Muriaux, Suzanne Peyrottes, Jean‐Jacques Vasseur, Michael Smietana, Christophe Mathé   +6 more
wiley   +1 more source

The Wonders of Vanilla: Celebrating the 150th Anniversary of Synthetic Vanillin

ChemFoodChem, Volume 2, Issue 2, June 2026.
The year 2024 marked the 150th anniversary of the first commercial production of vanillin, one of the world's most cherished flavor ingredients. This review traces vanilla's history from Mesoamerica to modern production methods, examines its composition, the discovery of vanillin and Haarmann's early synthesis compared to modern methods, and highlights
Elisabetta Brenna, Francesco G. Gatti, Fabio Parmeggiani   +2 more
wiley   +1 more source

bacNeo: A Computational Toolkit for Identifying Bacteria‐Derived Neoantigens in Human Cancers

iMetaMed, Volume 2, Issue 2, June 2026.
We present bacterial neoantigen (bacNeo), a multi‐omics‐based computational software to classify bacterial components (BACC), type bacteria‐bound HLA alleles (BACH), and prioritize bacterial peptides as neoantigens (BACP). Bacterial neoantigen potential is quantified by score for peptide antigenicity recognition & kinetics (SPARK), enabling ...
Yunzhe Wang, Li Yuan, Katie W. Gu, Xiangdong Cheng, Bo Wen, Zhao Zhang   +5 more
wiley   +1 more source

Selective Friedel–Crafts Acylation of N‐Tosylindoles Enabling a Concise Total Synthesis of Breitfussin B

ChemistrySelect, Volume 11, Issue 24, 25 June 2026.
A practical SnCl4‐mediated Friedel–Crafts acylation of N‐tosylindoles provides regioselective access to diverse 3‐acylindoles with substrate scope across substituted indoles. The utility of this method is demonstrated in a concise total synthesis of the halogen‐rich marine natural product Breitfussin B.
Yu‐Tung Tsai, Fang‐Yi Shih, Chun‐Fu Wu, Cheng‐Kun Lin   +3 more
wiley   +1 more source

Glycolaldehyde as a Bio-Based C₁ Building Block for Selective N-Formylation of Secondary Amines. [PDF]

ChemSusChem, 2022
Flynn MT, Liu X, Dell'Acqua A, Rabeah J, Brückner A, Baráth E, Tin S, de Vries JG.   +7 more
europepmc   +1 more source