Results 1 to 10 of about 17 (17)
N-glikozilacija imunoglobulina A u šećernoj bolesti tipa 1
, 2022 Šećerna bolest tipa 1 (T1DM) multifaktorska je, kronična i autoimuna bolest koja nastaje kao posljedica nedostatka endogenog lučenja inzulina iz β-stanica gušterače. Trenutno su dostupna dva biomarkera koji ukazuju na dugoročnu kontrolu dijabetesa – HbA1c i fruktozamin, ali oba imaju svoja ograničenja.
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N-glikozilacija imunoglobulina A ovisno o dobi i spolu ispitanika
, 2023 Changes in the N-glycosylation profile of immunoglobulin A have been proven to modify the function of the immune system, as glycans participate in the protein folding and transport process, as well as in the intracellular and extracellular signaling processes.
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N-glikozilacija proteina u plazmi kao biljeg praćenja metaboličkoga sindroma
, 2021 Metabolički sindrom obuhvaća poremećaje poput visceralne pretilosti te inzulinske rezistencije koja često prethodi šećernoj bolesti tipa 2. Istraživanja su spomenute poremećaje povezala s promjenama N-glikozilacije proteina plazme, jedne od najčešćih i najkompleksnijih post-translacijskih modifikacija.
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N-glikozilacija rekombinantnih terapeutskih glikoproteina u biljnim sustavima
Food Technology and Biotechnology, 2007 Transgenic plants have recently emerged as a promising system for low-cost and large-scale production of therapeutic proteins. Despite many advantages plants offer as hosts for expression of recombinant proteins, there are certain limitations caused by major structural differences between plant and mammalian N-linked glycans.
Balen, Biljana, Krsnik-Rasol, Marijana
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, 2021 Diabetes mellitus is a severe chronic disease caused by the inability of the pancreas to synthesize insulin or the inability of the body to functionally use synthesized insulin (WHO, 1999). Diabetes mellitus, according to the mechanism of disease development, can be divided into several subtypes, and the most commonly misdiagnosed type of diabetes is ...
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, 2020 Alpha-1 acid glycoprotein or orosomucoid is a plasma protein whose characteristics are associated with a high abundance of bound N-glycans of different complexity that are arranged across five different glycosylation sites on the protein and contribute to roughly 45% of its total mass.
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N-glikozilacija imunoglobulina G u upalnim bolestima crijeva
, 2018 The cause of inflammatory bowel disease (IBD) is still poorly understood and the most prominent forms Crohn’s disease (CD) and ulcerative colitis (UC) are sometimes hard to distinguish. Glycosylation of immunoglobulin G (IgG) has been associated with CD and UC. IgG Fc-glycosylation affects IgG effector functions.
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Insights into complexity of congenital disorders of glycosylation. [PDF]
Biochem Med (Zagreb), 2012 Goreta SS, Dabelic S, Dumic J.
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, 2019 Varfarin je najstariji i najpropisivaniji oralni antikoagulans. Zbog svoje uske terapijske širine i velikih interindividualnih varijabilnosti zahtijeva praćenje INR-a. Uspostavljanjem adekvatne inicijalne doze varfarina smanjuje se rizik od nuspojava lijeka i skraćuje vrijeme do postizanja optimalne koncentracije. Američka agencija za hranu i lijekove (
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, 2019 Chronic graft-versus-host disease (cGvHD) is a systemic alloimmune and autoimmune disorder and the major late complication and leading cause of non-relapse morbidity and mortality after allogeneic hematopoietic stem cell transplantation (alloHSCT). The disease is characterized by an altered homeostasis of the humoral immune response.
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