Results 201 to 210 of about 13,066,219 (329)

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source

Robustness Evaluation of a Legacy N-Glycan Profiling Method for a Therapeutic Antibody Under ICH Q14 Lifecycle Principles. [PDF]

Antibodies (Basel)
Hsieh MC, Li CR, Velardo MA, Zhang J, Parekh BS.   +4 more
europepmc   +1 more source

Modulating IgG effector function by Fc glycan engineering

Proceedings of the National Academy of Sciences of the United States of America, 2017
Tiezheng Li, D. DiLillo, S. Bournazos, John P. Giddens, J. Ravetch, Lai-Xi Wang   +5 more
semanticscholar   +1 more source

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

N-linked glycan structures and their expressions change in the blood sera of ovarian cancer patients.

Journal of Proteome Research, 2012
W. Alley, Jacqueline A Vasseur, John A. Goetz, M. Svoboda, B. Mann, D. Matei, N. Menning, A. Hussein, Y. Mechref, M. Novotny   +9 more
semanticscholar   +1 more source

Thermometer Ions, Internal Energies, and In‐Source Fragmentation in Ambient Ionization

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Ionization and fragmentation are at the core of mass spectrometry. But they are not necessarily separated in space, as in‐source fragmentation can also occur. Here, we survey the literature published since our 2005 review on the internal energy and fragmentation in electrospray ionization sources.
Emilie Bertrand, Valérie Gabelica
wiley   +1 more source

IgG N-Glycan Profiles in Mothers and Infants Postpartum in the Context of Maternal Obesity and Gestational Diabetes. [PDF]

Int J Mol Sci
Farkas A, Matsyura O, Besh L, Guttman A, Vari SG.   +4 more
europepmc   +1 more source

Antithrombin: Deficiency, Diversity, and the Future of Diagnostics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt, Christa M. Cobbaert, L. Renee Ruhaak   +2 more
wiley   +1 more source

A mass spectrometry-based assay for mouse IgG N-glycan screening in biofluids. [PDF]

Anal Bioanal Chem
Stratton AE, Moussa H, Guo Y, Ellenburg JM, Atkinson C, Prentice BM.   +5 more
europepmc   +1 more source