Results 221 to 230 of about 13,066,219 (329)

Biomolecular Interaction Prediction in the Pre‐ and Post‐AlphaFold Era: The 8th CAPRI Evaluation

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We report on the 8th CAPRI Evaluation period, capturing the assessment of CAPRI Rounds 47 to 55 (excluding the CASP and COVID‐related Rounds), which have witnessed the transition to AI‐driven prediction tools such as AlphaFold and related alternatives. The prediction Rounds in this evaluation are characterized by a high level of difficulty due
Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin   +5 more
wiley   +1 more source

In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini, Simona Saporiti, Crescenzo Coppa, Mara Rossi, Fabio Centola, Alessandro Arcovito   +5 more
wiley   +1 more source

Selective bioorthogonal probe for N-glycan hybrid structures. [PDF]

Nat Chem Biol
Mukherjee MM, Biesbrock D, Abramowitz LK, Pavan M, Kumar B, Walter PJ, Azadi P, Jacobson KA, Hanover JA.   +8 more
europepmc   +1 more source

Protein Involved in Initiation 1 Interaction With Starch Synthase 4 From Arabidopsis thaliana Induces Inhibition of Elongating Activity

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Starch is the major energy storage compound in plants. It accumulates in the form of insoluble, partly crystalline granules whose number and shape are specific to each plant species. These characteristics are defined very early in starch biosynthesis, at the initiation stage.
Mélanie Bossu, Rayan Osman, Guillaume Brysbaert, Marc Ferdinand Lensink, David Dauvillée, Coralie Bompard   +5 more
wiley   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

Spatial N-glycan rearrangement on α₅β₁ integrin nucleates galectin-3 oligomers to determine endocytic fate. [PDF]

Nat Commun
Shafaq-Zadah M, Dransart E, Hamitouche I, Wunder C, Chambon V, Valades-Cruz CA, Leconte L, Sarangi NK, Robinson J, Bai SK, Regmi R, Di Cicco A, Hovasse A, Bartels R, Nilsson UJ, Cianférani-Sanglier S, Leffler H, Keyes TE, Lévy D, Raunser S, Roderer D, Johannes L.   +21 more
europepmc   +1 more source

Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis.

Glycobiology, 2001
Yan Wang, Jenny Tan, M. Sutton‐Smith, David Ditto, M. Panico, Robert M. Campbell, N. Varki, Jeffrey M. Long, J. Jaeken, S. Levinson, A. Wynshaw-Boris, H. Morris, D. Le, A. Dell, H. Schachter, J. Marth   +15 more
semanticscholar   +1 more source

Deciphering Branched Galactomannan Structures via Multistage Ion Mobility MS and MSn Fragmentation (Multistage IMSn)

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale Hemicelluloses are abundant carbohydrate components in plant cell walls. They play a crucial structural role in binding cellulose microfibrils, in addition to other biological functions. Their high structural variability directly influences their biological properties, making it important to establish a structure–function ...
Rania Benazza, Mathieu Fanuel, Hélène Rogniaux, David Ropartz   +3 more
wiley   +1 more source

Unravelling Electronic Structure and Molecular Vibrations of Proteins in Virus Using Novel Correlated Plasmon‐Enhanced Raman Spectroscopy With Machine Learning

Small, EarlyView.
A novel, non‐destructive, stable, direct technique, named correlated plasmon‐enhanced Raman spectroscopy (CP‐ERS), which is based on a newly‐developed highly oriented single crystalline gold quantum dots (HOSG‐QDs) chip, is developed to measure and quantify molecular vibrations and electronic structure of analytes.
Vashu Kamboj, Shermine Ho, Fakhriedzwan Idris, Donald Heng Rong Ting, Khadijah Bte Kamsari Sanuh, Sylvie Alonso, Eng Soon Tok, Andrivo Rusydi   +7 more
wiley   +1 more source

A multi-analyte liquid biopsy approach for nonseminomatous testicular germ cell tumors: combining cfDNA and N-glycan analysis in blood and seminal plasma. [PDF]

Cancer Cell Int
Krasic J, Soic D, Abramovic LS, Kolosnjaj I, Tomic M, Vrtaric A, Oguic SK, Gelo N, Bojanac AK, Jezek D, Mitrecic D, Ulamec M, Kulis T, Gornik O, Sincic N.   +14 more
europepmc   +1 more source