Results 71 to 80 of about 13,562,347 (304)

Glycan-binding properties of lectins on endothelium.

, 2016
Glycan-binding properties of lectins on endothelium.
Ignacio A. Romero (305341), Simon Satchell (349295), Basil Sharrack (3080256), David Male (301682), Phil Williams (3080259), Mehmet Kaya (8651), Radka Gromnicova (377368)   +6 more
core   +1 more source

Silk Fibroin Nanofiber–Immobilized Horseradish Peroxidase Enables Continuous Preparation of Injectable Hydrogels With Negligible Residual Enzyme for Drug Delivery

Advanced Materials Technologies, EarlyView.
Overcoming the immunogenicity challenges of enzyme‐mediated crosslinking, a flow‐through reactor utilizing SFNF‐HRP enables the continuous production of injectable hydrogels. This continuous platform ensures homogeneous crosslinking while minimizing residual HRP in the resulting hydrogels.
Ayari Miyawaki, Shinji Sakai
wiley   +1 more source

Glyco-Decipher enables glycan database-independent peptide matching and in-depth characterization of site-specific N-glycosylation

Nature Communications, 2022
Poor peptide fragmentation and unusual glycan structures limit mass spectrometry-based analysis of intact N-glycopeptides. Here, the authors develop Glyco-Decipher, a glycan-independent peptide search tool, to tackle these issues and improve the coverage
Zheng Fang, Hongqiang Qin, Jiawei Mao, Zhongyu Wang, Na Zhang, Yan Wang, Luyao Liu, Yongzhan Nie, Mingming Dong, Mingliang Ye   +9 more
doaj   +1 more source

Expression and Display of Glycoengineered Antibodies and Antibody Fragments with an Engineered Yeast Strain

Antibodies, 2021
Interactions with cell surface receptors enhance the therapeutic properties of many important antibodies, including the low-affinity Fc γ Receptors (FcγRs). These interactions require proper processing of the immunoglobulin G Fc N-glycan, and eliminating
Anjali Shenoy, Srisaimaneesh Yalamanchili, Alexander R. Davis, Adam W. Barb   +3 more
doaj   +1 more source

Stability of N-glycan profiles in human plasma [PDF]

Glycobiology, 2009
Glycan heterogeneity was shown to be associated with numerous diseases and glycan analysis has a great diagnostic potential. Recently, we reported high biological variability of human plasma N-glycome at the level of population. The observed variations were larger than changes reported to be associated with some diseases; thus, it was of great ...
Gornik, Olga, Wagner, Jasenka, Pučić, Maja, Knežević, Ana, Redžić, Irma, Lauc, Gordan   +5 more
openaire   +3 more sources

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

N-glycan occupancy of Arabidopsis N-glycoproteins

, 2013
Most secreted proteins in eukaryotes are modified on the amino acid consensus sequence NxS/T by an N-glycan through the process of N-glycosylation. The N-glycans on glycoproteins are processed in the endoplasmic reticulum (ER) to different mannose-type N-
America, A.H.P., Dijk, A.D.J., van, Mentink, R., Song, W., Henquet, M.G.L., Cordewener, J.H.G., Bosch, H.J., Krol, A.R., van der   +7 more
core   +2 more sources

Non-targeted N-glycome profiling reveals multiple layers of organ-specific diversity in mice

Nature Communications
N-glycosylation is one of the most common protein modifications in eukaryotes, with immense importance at the molecular, cellular, and organismal level.
Johannes Helm, Stefan Mereiter, Tiago Oliveira, Anna Gattinger, David M. Markovitz, Josef M. Penninger, Friedrich Altmann, Johannes Stadlmann   +7 more
doaj   +1 more source

Rapid chemical de-N-glycosylation and derivatization for liquid chromatography of immunoglobulin N-linked glycans. [PDF]

PLoS ONE, 2018
Glycan analysis may result in exploitation of glycan biomarkers and evaluation of heterogeneity of glycosylation of biopharmaceuticals. For N-linked glycan analysis, we investigated alkaline hydrolysis of the asparagine glycosyl carboxamide of ...
Akihiko Kameyama, Santha Kumara Dissanayake, Wai Wai Thet Tin   +2 more
doaj   +1 more source

TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei [PDF]

, 2014
The procyclic form of Trypanosoma brucei expresses procyclin surface glycoproteins with unusual glycosylphosphatidylinositol-anchor side chain structures that contain branched N-acetyllactosamine and lacto-N-biose units.
Hashida, Kazunori, Ferguson, Michael A.J., Nakanishi, Masayuki, Karasudani, Moe, Nomoto, Hiroshi, Hino, Mami, Ferguson, Michael A. J; id_orcid, Shiraishi, Takahiro   +7 more
core   +1 more source