Results 51 to 60 of about 95,722 (299)

Plasma N-glycans in colorectal cancer risk [PDF]

Scientific Reports, 2018
AbstractAberrant glycosylation has been associated with a number of diseases including cancer. Our aim was to elucidate changes in whole plasmaN-glycosylation between colorectal cancer (CRC) cases and controls in one of the largest cohorts of its kind. A set of 633 CRC patients and 478 age and gender matched controls was analysed.
Margaret Doherty, Evropi Theodoratou, Ian Walsh, Barbara Adamczyk, Henning Stöckmann, Felix Agakov, Maria Timofeeva, Irena Trbojević-Akmačić, Frano Vučković, Fergal Duffy, Ciara A. McManus, Susan M. Farrington, Malcolm G. Dunlop, Markus Perola, Gordan Lauc, Harry Campbell, Pauline M. Rudd   +16 more
openaire   +4 more sources

Characterization of VRC01, a potent and broadly neutralizing anti-HIV mAb, produced in transiently and stably transformed tobacco [PDF]

, 2014
The proposed clinical trial in Africa of VRC01, a potent broadly neutralizing antibody (bNAb) capable of neutralizing 91% of known HIV-1 isolates, raises concerns about testing a treatment which will be too expensive to be accessible by the most ...
EMEA, Montefiori D.C., Pabst M., Pegu A., WHO   +4 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Glycosylated proteins preserved over millennia: N-glycan analysis of Tyrolean Iceman, Scythian Princess and Warrior. [PDF]

, 2014
An improved understanding of glycosylation will provide new insights into many biological processes. In the analysis of oligosaccharides from biological samples, a strict regime is typically followed to ensure sample integrity.
An, Hyun Joo, Bereuter, Thomas L, Dimapasoc, Lauren, Garrido, Daniel, Grimm, Rudolf, Kim, Bum Jin, Kim, Jae-Han, Lebrilla, Carlito B, Mills, David A, Ozcan, Sureyya, Reiter, Christian, Ro, Grace   +11 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Expression and Display of Glycoengineered Antibodies and Antibody Fragments with an Engineered Yeast Strain

Antibodies, 2021
Interactions with cell surface receptors enhance the therapeutic properties of many important antibodies, including the low-affinity Fc γ Receptors (FcγRs). These interactions require proper processing of the immunoglobulin G Fc N-glycan, and eliminating
Anjali Shenoy, Srisaimaneesh Yalamanchili, Alexander R. Davis, Adam W. Barb   +3 more
doaj   +1 more source

Serum N-glycan profile shift during human ageing [PDF]

Experimental Gerontology, 2010
Biomarkers indicating biological age are of significant interest for prevention, diagnosis and monitoring (and the treatment) of age-related diseases. We previously reported an alteration of serum N-glycan profile in old humans using "DNA Sequencer Adapted-Fluorophore Assisted Carbohydrate Electrophoresis" (DSA-FACE).
Vanhooren V., Dewaele S., Libert C., Engelborghs S., De Deyn P. P., Toussaint O., Debacq Chainiaux F., Poulain M., Glupczynski Y., FRANCESCHI, CLAUDIO, Jaspers K., van der Pluijm I., Hoeijmakers J., Chen C. C.   +13 more
openaire   +6 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Serum N-Glycan Profiling Predicts Prognosis in Patients Undergoing Hemodialysis

The Scientific World Journal, 2013
Background. The aim of this study is to evaluate the usefulness of serum N-glycan profiling for prognosis in hemodialysis patients. Methods. Serum N-glycan analysis was performed in 100 hemodialysis patients in June 2008 using the glycoblotting method ...
Shingo Hatakeyama, Maho Amano, Yuki Tobisawa, Tohru Yoneyama, Megumi Tsushima, Kazuko Hirose, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hisao Saitoh, Kanemitsu Yamaya, Tomihisa Funyu, Shin-Ichiro Nishimura, Chikara Ohyama   +13 more
doaj   +1 more source