Results 51 to 60 of about 13,562,347 (304)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Empirical predictions of an intrinsically disordered protein theory approach to glycan/lectin reaction kinetics [PDF]
, 2012 Newly-developed methods from the theory of intrinsically disordered proteins can be applied to the flexible glycan structures that coat cellular surfaces and provide rich channels for biological information transmission.
Rodrick Wallace
core
, 2018 Therapeutic monoclonal antibodies (mAbs) are largely based on the immunoglobulin G1 (IgG1) scaffold, and many elicit a cytotoxic cell-mediated response by binding Fc γ receptors.
Adam W. Barb (1350606) +3 more
core +1 more source
, 2022 Many pathogenic bacteria utilize glycan-based interactions to bind to host cells. Glycan array analysis and surface plasmon resonance are glycobioanalytical techniques that have been used to investigate the glycointeractions of a range of pathogens.
Pluschke, G. +7 more
core +1 more source
Analysis of Invertebrate and Protist N-Glycans [PDF]
, 2016 N-glycans from invertebrates and protists have often unusual structures which present analytical challenges. Both core and antennal modifications can be quite different from the more familiar vertebrate glycan motifs; thereby, contrary to the concept that "simple" organisms have "simple" N-glycans, rather complex oligosaccharides structures, including ...
Alba, Hykollari +3 more
openaire +2 more sources
Structure of Ten Free N-Glycans in Ripening Tomato Fruit (Arabinose Is a Constituent of a Plant N-Glycan) [PDF]
Plant Physiology, 1993 The concentration-dependent stimulatory and inhibitory effect of N-glycans on tomato (Lycopersicon esculentum Mill.) fruit ripening was recently reported (B. Priem and K.C. Gross [1992] Plant Physiol 98: 399-401). We report here the structure of 10 free N-glycans in mature green tomatoes.
B, Priem +3 more
openaire +2 more sources
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Beyond the fuzzy lock-and-key: spontaneous symmetry shifts and glycan/lectin logic gates [PDF]
, 2012 Changes in the molecular topology of glycan/lectin interaction may explain observed reaction punctuation driven by experimental gradients in reactant concentration. Adoption of a 'biological renormalization' perspective from statistical physics
Rodrick Wallace
core
GlycoVis: Visualizing Glycan Distribution in the Protein N-Glycosylation Pathwayin Mammalian Cells
, 2016 Glycosylation pattern is an important quality attribute of protein therapeutics. It affects protein stability, half-life and even biological functions. The N-glycosylation pathway is a highly branched network.
Hossler, Patrick, Hu, Wei-Shou
core +1 more source