Results 61 to 70 of about 13,562,347 (304)

Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase. [PDF]

, 2022
Oligosaccharyltransferase (OST) is the central enzyme of N-linked protein glycosylation. It catalyzes the transfer of a pre-assembled glycan, GlcNAc2Man9Glc3, from a dolichyl-pyrophosphate donor to acceptor sites in secretory proteins in the lumen of the
Pesciullesi, Giorgio, Reymond, Jean-Louis, De Capitani, Mario, Locher, Kaspar P, Locher, Kaspar P., Ramírez, Ana S., Bloch, Joël S., Bloch, Joël S, Irobalieva, Rossitza N, Aebi, Markus, Kowal, Julia, Irobalieva, Rossitza N., Ramírez, Ana S   +12 more
core   +2 more sources

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

The Association Between Normal BMI With Central Adiposity And Proinflammatory Potential Immunoglobulin G N-Glycosylation

Diabetes, Metabolic Syndrome and Obesity, 2019
Di Liu,1,* Qihuan Li,1,2,* Jing Dong,3 Dong Li,4 Xizhu Xu,4 Weijia Xing,4 Xiaoyu Zhang,1 Weijie Cao,1 Haifeng Hou,4 Hao Wang,1,5 Manshu Song,1 Lixin Tao,1 Xiaoping Kang,6 Qun Meng,1 Wei Wang,1,4,5 Xiuhua Guo,1 Youxin Wang1 1Beijing Key Laboratory of ...
Liu D, Li Q, Dong J, Li D, Xu X, Xing W, Zhang X, Cao W, Hou H, Wang H, Song M, Tao L, Kang X, Meng Q, Wang W, Guo X, Wang Y   +16 more
doaj  

N-Glycan distribution for 5-L treatments.

, 2016
N-Glycan distribution for 5-L treatments.
Nelly Aranibar (2208076), Bethanne Warrack (1429879), William D. Croughan (2838833), Michael C. Borys (2838839), Michael D. Reily (2107309), Nicholas R. Abu-Absi (2838842), Amanda M. Lewis (1967365), Alison G. Lee (2838845), Rutva Patel (2838848), Barry Drew (2838836), Zheng Jian Li (2838830)   +10 more
core   +1 more source

Glycan-specific median RF feature importance percentiles within PLIP features.

, 2021
Median feature importance percentiles of PLIP features (within the PLIP features only) from each glycan-specific RF model determined via mean decrease in Gini impurity.
Chris Bailey-Kellogg (682345), Daniel E. Mattox (10043639)   +1 more
core   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Plasma High-Mannose and Complex/Hybrid N-Glycans Are Associated with Hypercholesterolemia in Humans and Rabbits.

PLoS ONE, 2016
N-glycans play important roles in various pathophysiological processes and can be used as clinical diagnosis markers. However, plasma N-glycans change and their pathophysiological significance in the setting of hypercholesterolemia, a major risk factor ...
Liang Bai, Qianwei Li, Lingmei Li, Yan Lin, Sihai Zhao, Weirong Wang, Rong Wang, Yongqin Li, Jiangbei Yuan, Chengjian Wang, Zhongfu Wang, Jianglin Fan, Enqi Liu   +12 more
doaj   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Serum Linkage-Specific Sialylation Changes Are Potential Biomarkers for Monitoring and Predicting the Recurrence of Papillary Thyroid Cancer Following Thyroidectomy

Frontiers in Endocrinology, 2022
BackgroundAlthough papillary thyroid cancer (PTC) could remain indolent, the recurrence rates after thyroidectomy are approximately 20%. There are currently no accurate serum biomarkers that can monitor and predict recurrence of PTC after thyroidectomy ...
Zhen Cao, Zejian Zhang, Rui Liu, Mengwei Wu, Zepeng Li, Xiequn Xu, Ziwen Liu   +6 more
doaj   +1 more source

Extending Tlusty's method to the glycome: Tuning the repertoire of glycan determinants [PDF]

, 2011
We apply Tlusty's information-theoretic analysis of the genetic code to the glycome, using a cognitive paradigm in which external information sources constrain and tune the glycan code error network, in the context of available metabolic energy. The
Rodrick Wallace, Deborah Wallace
core