Results 81 to 90 of about 13,066,219 (329)

Serum N-Glycan Profiling Predicts Prognosis in Patients Undergoing Hemodialysis

The Scientific World Journal, 2013
Background. The aim of this study is to evaluate the usefulness of serum N-glycan profiling for prognosis in hemodialysis patients. Methods. Serum N-glycan analysis was performed in 100 hemodialysis patients in June 2008 using the glycoblotting method ...
Shingo Hatakeyama, Maho Amano, Yuki Tobisawa, Tohru Yoneyama, Megumi Tsushima, Kazuko Hirose, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hisao Saitoh, Kanemitsu Yamaya, Tomihisa Funyu, Shin-Ichiro Nishimura, Chikara Ohyama   +13 more
doaj   +1 more source

Mutations in HNF1A Result in Marked Alterations of Plasma Glycan Profile

Diabetes, 2013
A recent genome-wide association study identified hepatocyte nuclear factor 1-α (HNF1A) as a key regulator of fucosylation. We hypothesized that loss-of-function HNF1A mutations causal for maturity-onset diabetes of the young (MODY) would display altered
G. Thanabalasingham, J. Huffman, J. Kattla, M. Novokmet, Igor Rudan, A. Gloyn, C. Hayward, B. Adamczyk, Rebecca M. Reynolds, A. Mužinić, N. Hassanali, M. Pučić, A. Bennett, Abdelkader Essafi, O. Polašek, S. Mughal, Irma Redžić, D. Primorac, L. Zgaga, I. Kolčić, T. Hansen, D. Gašperíková, E. Tjora, M. Strachan, T. Nielsen, J. Stanik, Iwar Klimes̆, Oluf Pedersen, P. Njølstad, Sarah H Wild, U. Gyllensten, O. Gornik, James F. Wilson, Nick Hastie, H. Campbell, M. McCarthy, Pauline M. Rudd, K. Owen, G. Lauc, Alan F. Wright   +39 more
semanticscholar   +1 more source

RESOLVING EXTENDED N‐GLYCANS BY NMR: NEW INSIGHTS INTO INFLUENZA HEMAGGLUTININ N‐GLYCAN INTERACTIONS

The FASEB Journal, 2018
Seasonal flu (influenza virus infection) is one of the major threats to human health, causing of up to 500 thousands deaths worldwide annually.1,2 Hemagglutinin, a glycoprotein presented in the surface of the influenza virus, binds sialylated N‐glycans located on the surface of host epithelial cells. The structural elucidation and the
Beatriz Fernández de Toro Ronda, Wenjie Peng, Andrew Thompson, Gema Domínguez, F. Javier Cañada, Javier Pérez Castells, Jesús Jiménez Barbero, James C. Paulson, Ángeles Canales   +8 more
openaire   +1 more source

A Chemoenzymatic Method for Glycoproteomic N-glycan Type Quantitation [PDF]

Analytical Chemistry, 2019
ABSTRACTGlycosylation is one of the most important post-translational modifications in biological systems. Current glycoproteome methods mainly focus on qualitative identification of glycosylation sites or intact glycopeptides. However, the systematic quantitation of glycoproteins has remained largely unexplored.
Henghui Li, Leyuan Li, Kai Cheng, Zhibin Ning, Janice Mayne, Xu Zhang, Krystal Walker, Rui Chen, Susan Twine, Jianjun Li, Daniel Figeys   +10 more
openaire   +3 more sources

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Plasma High-Mannose and Complex/Hybrid N-Glycans Are Associated with Hypercholesterolemia in Humans and Rabbits.

PLoS ONE, 2016
N-glycans play important roles in various pathophysiological processes and can be used as clinical diagnosis markers. However, plasma N-glycans change and their pathophysiological significance in the setting of hypercholesterolemia, a major risk factor ...
Liang Bai, Qianwei Li, Lingmei Li, Yan Lin, Sihai Zhao, Weirong Wang, Rong Wang, Yongqin Li, Jiangbei Yuan, Chengjian Wang, Zhongfu Wang, Jianglin Fan, Enqi Liu   +12 more
doaj   +1 more source

Rapid chemical de-N-glycosylation and derivatization for liquid chromatography of immunoglobulin N-linked glycans. [PDF]

PLoS ONE, 2018
Glycan analysis may result in exploitation of glycan biomarkers and evaluation of heterogeneity of glycosylation of biopharmaceuticals. For N-linked glycan analysis, we investigated alkaline hydrolysis of the asparagine glycosyl carboxamide of ...
Akihiko Kameyama, Santha Kumara Dissanayake, Wai Wai Thet Tin   +2 more
doaj   +1 more source

Serum Linkage-Specific Sialylation Changes Are Potential Biomarkers for Monitoring and Predicting the Recurrence of Papillary Thyroid Cancer Following Thyroidectomy

Frontiers in Endocrinology, 2022
BackgroundAlthough papillary thyroid cancer (PTC) could remain indolent, the recurrence rates after thyroidectomy are approximately 20%. There are currently no accurate serum biomarkers that can monitor and predict recurrence of PTC after thyroidectomy ...
Zhen Cao, Zejian Zhang, Rui Liu, Mengwei Wu, Zepeng Li, Xiequn Xu, Ziwen Liu   +6 more
doaj   +1 more source

Harnessing the natural anti-glycan immune response to limit the transmission of enveloped viruses such as SARS-CoV-2

PLoS Pathogens, 2020
Enveloped viruses are glycosylated, meaning that their envelope proteins are post-translationally modified by the addition of glycans. Some glycosyltransferases that contribute to terminate glycan chains synthesis are differentially expressed between ...
A. Breiman, Nathalie Ruvën-Clouet, J. Le Pendu   +2 more
semanticscholar   +1 more source

A structural and functional model for human bone sialoprotein [PDF]

, 2012
Human bone sialoprotein (BSP) is an essential component of the extracellular matrix of bone. It is thought to be the primary nucleator of hydroxyapatite crystallization, and is known to bind to hydroxyapatite, collagen, and cells.
Durrant, Marcus, Vincent, Kevin
core   +1 more source