Results 251 to 260 of about 10,628,077 (304)

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, EarlyView.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

50 years in the making: acp³U, an amino-acid-containing nucleoside, links N-glycans and RNA in glycoRNA. [PDF]

Mol Cell
Steinbuch KB, Tor Y.
europepmc   +1 more source

Development of Chimeric Antigen Receptor‐Modified NK Cells for the Immunotherapy of Adult T‐Cell Leukemia/Lymphoma

European Journal of Haematology, EarlyView.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy with a poor prognosis and limited therapeutic options. ATL cells exhibit aberrant surface glycosylation patterns resulting from dysregulated glycosyltransferase expression, representing a potentially tumor‐specific therapeutic target.
Yuichiro Uchida, Seigo Tateo, Masahiro Wakao, Hiroyuki Shinchi, Hayate Sawayama, Akira Fukumoto, Makoto Yoshimitsu, Yasuo Suda   +7 more
wiley   +1 more source

Trimmed <i>N</i>-glycans define aggressive gastric cancer and predict clinical outcomes. [PDF]

Theranostics
Ferreira D, Marinho-Santos B, Relvas-Santos M, Orr B, Brandão A, Afonso LP, Santos LL, Ferreira JA.   +7 more
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike:ACE2 receptor binding and virus priming. [PDF]

Proc Natl Acad Sci U S A
Paiardi G, Ferraz M, Rusnati M, Wade RC.
europepmc   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Mechanistic study of SCOOPs recognition by MIK2-BAK1 complex reveals the role of N-glycans in plant ligand-receptor-coreceptor complex formation. [PDF]

Nat Plants
Wu H, Wan L, Liu Z, Jian Y, Zhang C, Mao X, Wang Z, Wang Q, Hu Y, Xiong L, Xia Z, Xue J, Li S, He P, Shan L, Xu S.   +15 more
europepmc   +1 more source

High-Mannose <i>N</i>-Glycans To Monitor Early Response to Chemotherapy in African Epithelial Ovarian Cancer Patients─A Pilot Study. [PDF]

J Proteome Res
Wanyama FM, Umeh O, Biskup K, Tauber R, Mokomba A, Nyongesa C, Blanchard V.   +6 more
europepmc   +1 more source

Recognition of Highly Branched N-Glycans of the Porcine Whipworm by the Immune System. [PDF]

Mol Cell Proteomics
Eckmair B, Gao C, Mehta AY, Dutkiewicz Z, Vanbeselaere J, Cummings RD, Paschinger K, Wilson IBH.   +7 more
europepmc   +1 more source