Results 31 to 40 of about 9,398 (90)
ABSTRACT Cadmium (Cd) is a significant environmental pollutant with widespread detrimental effects on living organisms, making it a frequent subject of laboratory studies. However, different types of Cd salts are used to spike media, often without considering the possibility that accompanying anions may influence the effects of metal cations. Using two
Martin Lyčka +6 more
wiley +1 more source
In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization
ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini +5 more
wiley +1 more source
Fetal‐placental communication was explored by comparing protein abundances in paired umbilical artery and vein samples, using the SomaLogic 5000‐plex platform. 766 proteins were identified as released by the placenta, largely supported by placental gene expression patterns reported in transcriptomic studies.
Hilde Bastøe Sellevoll +6 more
wiley +1 more source
High‐Throughput Screen of NPQ in Sorghum Shows Highly Polygenic Architecture of Photoprotection
ABSTRACT Natural genetic variation in photosynthesis and photoprotection within crop germplasm represents an untapped resource for crop improvement. Sorghum bicolor (sorghum) is one of the world's most widely grown crops, yet the genetic basis of photoprotection in sorghum is not well understood.
Richard L. Vath +9 more
wiley +1 more source
Luvangetin, a coumarin compound from Zanthoxylum avicennae roots, affects the cell wall degradation capacity and pathogenicity of Fusarium verticillioides on maize. Integrated transcriptomic, proteomic and in vitro activity analyses revealed that it binds to three critical sites of the Fusarium glycoside hydrolase 3 family (GH3) β‐glucosidase ...
Duxuan Liu +10 more
wiley +1 more source
Molecular mechanisms of plant NLR activation and signalling
SUMMARY Plants rely on NLRs (nucleotide‐binding leucine‐rich repeat receptors) to recognise effector proteins secreted by pathogens into plant cells and to deliver disease resistance. Plant NLRs are broadly characterised by their N‐terminal domains, which include the TIR (Toll/interleukin‐1 receptor) and the CC (coiled‐coil) domains.
Natsumi Maruta +3 more
wiley +1 more source
Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley +1 more source
This study depicting the role of transcriptomics, RNA interference (RNAi), and CRISPR/Cas9 technologies in the breeding of glandless cottonseed and glanded cotton tissues. This approach demonstrates the potential of cotton as a dual‐purpose crop, serving both the fiber industry and as a sustainable food and feed source.
Teame Gereziher Mehari +9 more
wiley +1 more source
SNRK3.15 Is a Crucial Component of the Sulfur Deprivation Response in Arabidopsis thaliana
ABSTRACT Sulfate deprivation (–S) results in numerous metabolic and phenotypic alterations in plants. Kinases are often key players in transducing nutrient status signals to molecular components involved in metabolic and developmental program regulation, but despite the physiological importance of sulfur, to date, no signaling kinases have been ...
Anastasia Apodiakou +8 more
wiley +1 more source
Cereal Arabinoxylans—Their Enzymatic Degradation and Relevance for Breadmaking and Human Health
ABSTRACT As the most abundant nonstarch polysaccharides in cereals, arabinoxylans (AXs) contribute significantly to the global intake of dietary fiber. They play a crucial role in the breadmaking process with respect to dough rheology and texture, bread volume, and nutritional quality, especially when starting from wheat or rye flour.
Víctor González‐Alonso +3 more
wiley +1 more source

