Results 101 to 110 of about 13,659,719 (307)

Bisecting GlcNAc Protein N-Glycosylation Is Characteristic of Human Adipogenesis

, 2020
Human adipose tissue contains a major source of adipose-derived stem cells (ADSCs) that have the ability to differentiate into various cell types: in vitro, ADSCs can differentiate into mesenchymal lineages including adipocytes, while in vivo, ADSCs ...
Wongtrakul-Kish, Katherine, Packer, Nicolle H, Herbert, Benjamin R, Katherine Wongtrakul-Kish, Benjamin R. Herbert, Nicolle H. Packer   +5 more
core   +1 more source

Table_7_Heritability Enrichment of Immunoglobulin G N-Glycosylation in Specific Tissues.xlsx

, 2021
Genome-wide association studies (GWAS) have identified over 60 genetic loci associated with immunoglobulin G (IgG) N-glycosylation; however, the causal genes and their abundance in relevant tissues are uncertain.
Yahong Zhu (10931715), Manshu Song (153063), Xuerui Tan (324728), Xiuhua Guo (311454), Jingdong J. Han (11638780), Weijie Cao (3188991), Haifeng Hou (622765), Wei Wang (17594), Youxin Wang (153032), Minglin Lang (168413), Xingang Li (319129), Hao Wang (39217)   +11 more
core   +1 more source

Charting the Future of Stereoselective Carbohydrate Synthesis: The Essential Role of Cross‐Disciplinary Innovation

Advanced Science, EarlyView.
Cross‐disciplinary endeavors are blossoming across the broad chemical sciences. This perspective provides a glimpse into the rewarding interdisciplinary journey taken by the Charles Loh research group in pioneering the σ‐hole based catalytic glycosylation strategy.
Charles C. J. Loh
wiley   +1 more source

Defining albumin as a glycoprotein with multiple N-linked glycosylation sites

Journal of Translational Medicine
Background Glycosylation is an enzyme-catalyzed post-translational modification that is distinct from glycation and is present on a majority of plasma proteins.
Kishore Garapati, Anu Jain, Benjamin J. Madden, Dong-Gi Mun, Jyoti Sharma, Rohit Budhraja, Akhilesh Pandey   +6 more
doaj   +1 more source

Raider of the lost N-glycans – Localizing rare and frequently overlooked IgG N-glycans with sulfation or bisecting LacNAc

Frontiers in Molecular Biosciences
Immunoglobulin G (IgG) is the most abundant immunoglobulin in human blood. Here it plays a central role in the immune system by recognizing antigens and mediating effector functions of the humoral immune defense.
Robert Burock, Léa Chuzel, Thilo Kähne, Udo Reichl, Udo Reichl, Erdmann Rapp, Erdmann Rapp, René Hennig   +7 more
doaj   +1 more source

Redesigning N-glycosylation sites in a GH3 β-xylosidase improves the enzymatic efficiency

Biotechnology for Biofuels, 2019
Background β-Xylosidases are glycoside hydrolases (GHs) that cleave xylooligosaccharides and/or xylobiose into shorter oligosaccharides and xylose.
Marcelo Ventura Rubio, César Rafael Fanchini Terrasan, Fabiano Jares Contesini, Mariane Paludetti Zubieta, Jaqueline Aline Gerhardt, Leandro Cristante Oliveira, Any Elisa de Souza Schmidt Gonçalves, Fausto Almeida, Bradley Joseph Smith, Gustavo Henrique Martins Ferreira de Souza, Artur Hermano Sampaio Dias, Munir Skaf, André Damasio   +12 more
doaj   +1 more source

Congenital Disorders of N-Glycosylation Including Diseases Associated With O- as Well as N-Glycosylation Defects [PDF]

Pediatric Research, 2006
The congenital disorders of N-glycosylation (CDG), a steadily increasing group of multi-systemic disorders, have severe clinical implications in infancy and early childhood. The various inborn errors responsible adversely affect N-glycosylation of lysosomal proteins because of either failing assembly of lipid-linked (LL) oligosaccharides (OS) in the ...
openaire   +2 more sources

Table_6_Heritability Enrichment of Immunoglobulin G N-Glycosylation in Specific Tissues.xlsx

, 2021
Genome-wide association studies (GWAS) have identified over 60 genetic loci associated with immunoglobulin G (IgG) N-glycosylation; however, the causal genes and their abundance in relevant tissues are uncertain.
Yahong Zhu (10931715), Manshu Song (153063), Xuerui Tan (324728), Xiuhua Guo (311454), Jingdong J. Han (11638780), Weijie Cao (3188991), Haifeng Hou (622765), Wei Wang (17594), Youxin Wang (153032), Minglin Lang (168413), Xingang Li (319129), Hao Wang (39217)   +11 more
core   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source