Results 211 to 220 of about 155,572 (257)
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Function of N-glycosylation in plants
Plant Science, 2018Protein N-glycosylation is one of the major post-translational modifications in eukaryotic cells. In lower unicellular eukaryotes, the known functions of N-glycans are predominantly in protein folding and quality control within the lumen of the endoplasmic reticulum (ER).
Yukihiro, Nagashima +2 more
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Facile synthesis of N-glycosyl amides using a N-glycosyl-2,4-dinitrobenzenesulfonamide and thioacids
Carbohydrate Research, 2009N-Glucosyl-2,4-dinitrobenzenesulfonamide was prepared from N-acetyl-d-glucosamine and 2,4-dinitrobenzenesulfonyl chloride. Amidation of several thioacids using the N-glucosylsulfonamide donor proceeded smoothly to give the desired N-glucosylamides in good to high yields.
Rommel S, Talan +2 more
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Stereochemistry of the N-glycosylation sites in glycoproteins
Protein Engineering Design and Selection, 1995The stereochemical features displayed by the N-glycosidic linkage in crystalline N-linked glycoproteins are analyzed. From the statistical analysis of 44 different glycosylation sites belonging to 26 glycoproteins of the Brookhaven Protein Data Bank, a mean standard geometry for the GlcNAc moiety, along with a rationalization of its conformational ...
Imberty, A., Perez, Sarah
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The humanization of N-glycosylation pathways in yeast
Nature Reviews Microbiology, 2005Yeast and other fungal protein-expression hosts have been extensively used to produce industrial enzymes, and are often the expression system of choice when manufacturing costs are of primary concern. However, for the production of therapeutic glycoproteins intended for use in humans, yeast have been less useful owing to their inability to modify ...
Stefan, Wildt, Tilllman U, Gerngross
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N-Glycosylation and Plant Cell Growth
2014N-linked glycosylation is one of the most prevalent cotranslational protein modifications in plants. It is initiated by a conserved process in the endoplasmic reticulum and subsequently involves a series of different N-glycan maturation steps that take place in the ER and Golgi apparatus.
Christiane, Veit +2 more
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The N-glycosylation pattern of Caenorhabditis elegans
Carbohydrate Research, 2008Determining the exact nature of N-glycosylation in Caenorhabditis elegans, a nematode worm and genetic model organism, has proved to have been an unexpected challenge in recent years; a wide range of modifications of its N-linked oligosaccharides have been proposed on the basis of structural and genomic analysis. Particularly mass spectrometric studies
Katharina, Paschinger +3 more
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Characterization of Protein N‐Glycosylation
2005Although mass spectrometry (MS)-based protein identification is a straightforward task, the characterization of most posttranslational modifications still represents a challenge. N-glycosylation with its well known consensus sequence, common core structure, and "universally" active endoglycosidase seems to belong to the easier category. In this chapter,
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Integrin α5β1 and Its N-Glycosylation
2014Integrins are transmembrane heterodimeric proteins sensing the cell microenvironment and modulating numerous signaling pathways. Changes in integrin function and expression between normal and tumor cells support involvement of specific integrins in tumor progression and aggressiveness.
Jianguo Gu +3 more
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N-Glycosylation in Chrysosporium lucknowense enzymes
Carbohydrate Research, 2008Twenty-eight enzymes, encoded by different genes and secreted by different mutant strains of Chrysosporium lucknowense, were subjected to MALDI-TOF MS peptide fingerprinting followed by analysis of the MS data using the GlycoMod tool from the ExPASy proteomic site. Various N-linked glycan structures were discriminated in the C.
Alexander V, Gusakov +2 more
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