Results 101 to 110 of about 111,646 (306)

Positive modulation of N-methyl-D-aspartate receptors in the mPFC reduces the spontaneous recovery of fear. [PDF]

Mol Psychiatry, 2022
Lee B, Pothula S, Wu M, Kang H, Girgenti MJ, Picciotto MR, DiLeone RJ, Taylor JR, Duman RS.   +8 more
europepmc   +1 more source

Electroclinical phenotypes—genetic characterization of developmental and epileptic encephalopathies in a cohort study

Epileptic Disorders, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by refractory seizures and frequently recurring epileptic activity with neurodevelopmental delay or regression that usually begin in early life. We aimed to define the relationship between electroclinical features and etiology, as well as the genotype–phenotype ...
Burcu Yaman, Fulya Kurekci, Sinan Akbas, Ceyda Oney, Mehmet Akif Kilic, Hulya Maras Genc, Ayca Dilruba Aslanger, Edibe Pembegul Yildiz   +7 more
wiley   +1 more source

Anti-N-methyl-D-aspartate receptor encephalitis: a new autoimmune encephalitis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
Anti-N-methyl-D-aspartate (anti-NMDA ) receptor encephalitis is a new category of treatable encephalitis associated with anti-NMDA receptor antibody, which attracts more and more attention recently.
Xiang-jun Chen, Xiang Li
doaj  

Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor

Communications Biology
Epsilon ionotropic glutamate receptors (iGluRs) are a recently defined clade of neurotransmitter receptors that are found in all major metazoan lineages that are distinct from α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, delta ...
Anhadvir Singh, Boris S. Zhorov, Luis A. Yanez-Guerra, Alessandra Aleotti, Chloe C. Koens, C. Defne Yanartas, Yunqi Song, Federico Javier Miguez Cabello, Derek Bowie, Adriano Senatore   +9 more
doaj   +1 more source

Mechanosensitivity of N-methyl-D-aspartate receptors (NMDAR) is the key through which amyloid beta oligomers activate them. [PDF]

Neural Regen Res, 2022
Fani G, Chiti F.
europepmc   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source

Molecular continuity between axon guidance and synaptic function

Molecules and Cells
: The precise assembly of neural circuits is a marvel of cellular engineering, requiring the seamless coordination of long-range axon navigation and short-range synapse formation.
Seongjun Kim, Hye Jin Cho, I-Hao Wang, Sung Jin Park   +3 more
doaj   +1 more source

Pyruvate dehydrogenase autoantibodies in autoantibody‐negative patients with seizures are associated with reduced pyruvate dehydrogenase activity

Epilepsia, EarlyView.
Abstract Objective We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Annika Breuer, Chiara A. Hummel, Tobias Baumgartner, Juliane L. Berns, Afaf Milad Said, Isabel Bünger, Susanne Schoch, Gábor Zsurka, Harald Prüss, Wolfram S. Kunz, Rainer Surges, Albert J. Becker, Julika Pitsch   +12 more
wiley   +1 more source

Long‐term prognosis of pharmacotherapy in newly diagnosed focal epilepsy patients and the predictive value of baseline seizure timing: A prospective cohort study

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a highly heterogeneous neurological disorder with significant prognostic variability. Accurate long‐term outcome prediction remains a clinical challenge. We investigated pharmacotherapeutic prognosis and key predictors, particularly baseline seizure timing, to guide individualized treatment.
Lei Sun, Shouye Sun, Xinyue Zhang, Weihong Lin   +3 more
wiley   +1 more source

Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors. [PDF]

Pharmaceuticals (Basel), 2022
Bettini E, Stahl SM, De Martin S, Mattarei A, Sgrignani J, Carignani C, Nola S, Locatelli P, Pappagallo M, Inturrisi CE, Bifari F, Cavalli A, Alimonti A, Pani L, Fava M, Traversa S, Folli F, Manfredi PL.   +17 more
europepmc   +1 more source