Results 111 to 120 of about 10,564,162 (159)

Comparative safety, pharmacokinetics, and off-target assessment of 1,1-bis(3'-indolyl)-1-(<i>p</i>-chlorophenyl) methane in mouse and dog: implications for therapeutic development. [PDF]

Toxicol Res (Camb)
Rocha SM, Gustafson DL, Safe S, Tjalkens RB.   +3 more
europepmc   +1 more source

The cellular distribution of P2X7, P2Y6, and P2Y12 during or after pilocarpine-induced status epilepticus and literature review. [PDF]

Brain Circ
Li Y, Tang F, Luo Y.
europepmc   +1 more source

Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticus. [PDF]

Acta Neuropathol Commun
Liu L, Wang Y, Wang X, Zhang G, Sha S, Zhou R, Du Y, Wu C, Chen L.   +8 more
europepmc   +1 more source

Regulatory Mechanism of CRTC1 on Autophagy and GluA2 Expression in Epilepsy. [PDF]

Mol Neurobiol
Wang X, Zhou L, Yang L, Huang S, Wang Y, Li D.   +5 more
europepmc   +1 more source

Effect of aging on the interaction of quinuclidinyl benzilate, N-methylscopolamine, pirenzepine, and gallamine with brain muscarinic receptors

Neurochemical Research, 1988
The objective of the present study was to investigate the effects of senescence on the binding characteristics of muscarinic receptors by using [3H]quinuclidinyl benzilate ([3H]QNB) and [3H]N-methylscopolamine ([3H]NMS) as ligands in young (3 months), middle-age (10 months) and old (24 months) male Fischer 344 rats.
W, Surichamorn, O N, Kim, N H, Lee, W S, Lai, E E, el-Fakahany   +4 more
openaire   +3 more sources

Discrepancies in the Specific Activity of ³ H-N-Methylscopolamine as Determined by Mass Spectrometry and Radioreceptor Assay due to Racemisation

Journal of Receptor Research, 1988
In radioligand binding studies, the accuracy of the specific activity of the radiolabeled ligand has a large impact on the calculated receptor concentration and on the calculated affinities of both labeled and competitive ligands. A radioreceptor assay for anticholinergic drugs was employed to determine the specific activity of 3H-N-methylscopolamine ...
Ensing, K., Bloemhof, D. A., In 't Hout, W. G., De Zeeuw, R. A.   +3 more
openaire   +3 more sources

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Anomalous binding of [3H]N-methylscopolamine to rat brain muscarinic receptors

European Journal of Pharmacology, 1985
In the present studies, we investigated the binding properties of [3H]quinuclidinyl benzilate ([3H]QNB) and [3H]N-methylscopolamine ([3H]NMS) to muscarinic acetylcholine receptors (mAChR) in rat brain homogenates. Our results indicate that the hydrophilic receptor ligand, [3H]NMS, is able to interact with high affinity only with a fraction of the ...
Esam E El-Fakahany
exaly   +3 more sources

[3H]N-methylscopolamine dissociation from muscarine receptors affected by low concentrations of allosteric modulators

European Journal of Pharmacology, 1995
The ability of allosteric ligands to modulate the dissociation rate of [3H]N-methylscopolamine from atrial muscarinic receptors in the presence of varying concentrations of unlabelled N-methylscopolamine or atropine was evaluated. Gallamine, at a concentration approximating its KD value, slowed the dissociation of [3H]N-methylscopolamine in the ...
Arthur Christopoulos, F Mitchelson
exaly   +3 more sources

Potentiation by alcuronium of the antimuscarinic effect of N-methylscopolamine in guinea pig left atria

European Journal of Pharmacology, 1995
Alcuronium is known to stabilize allosterically the binding of the muscarinic antagonist N-methylscopolamine to muscarinic M2 receptors and thus to elevate the equilibrium binding of N-methylscopolamine in homogenized cardiac tissue. In order to check for a functional consequence of this effect, the action of alcuronium alone and in combination with N ...
Evi Kostenis, Klaus Mohr
exaly   +3 more sources