Succinamide Derivatives Ameliorate Neuroinflammation and Oxidative Stress in Scopolamine-Induced Neurodegeneration [PDF]
Biomolecules, 2020 Oxidative stress-mediated neuroinflammatory events are the hallmark of neurodegenerative diseases. The current study aimed to synthesize a series of novel succinamide derivatives and to further investigate the neuroprotective potential of these compounds
Sumbal Iqbal +9 more
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The memory ameliorating effects of novel N-benzyl pyridine-2-one derivatives on scopolamine-induced cognitive deficits in mice [PDF]
Laboratory Animal ResearchBackground Alzheimer's disease (AD), the most common form of progressive dementia in the elderly, is a chronic neurological disorder that decreases cognitive ability.
Swati Pant +4 more
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Effect of sulfonamide derivatives of phenylglycine on scopolamine‐induced amnesia in rats
Ibrain, 2023 Alzheimer's disease is a neurodegenerative disease responsible for dementia and other neuropsychiatric symptoms. In the present study, compounds 30 and 33, developed earlier in our laboratory as selective butyrylcholinesterase inhibitors, were tested ...
Ankit Ganeshpurkar +6 more
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Neuroprotective Potential of New Monoterpene-Adamatane Conjugates—A Pilot Study [PDF]
Current Issues in Molecular BiologyNeurodegenerative diseases, including Alzheimer’s disease, are marked by cholinergic dysfunction, oxidative stress, and reduced neurotrophic support, which drives the quest for multifunctional therapeutic agents.
Stela Dragomanova +18 more
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A Novel Probiotic Limosilactobacillus fermentum IOB802 and Its Postbiotic Alleviate Cognitive Impairment Induced by Scopolamine in Mice [PDF]
FoodsCognitive impairment is acknowledged as an early stage between normal aging and Alzheimer’s disease, emphasizing the need for prompt intervention. There is growing evidence that the gut–brain axis plays a role in regulating cognitive function, indicating
Yuxuan Song +9 more
doaj +2 more sources
Bioorganic Chemistry, Toxinology, and Pharmaceutical Uses of Datura Metabolites and Derivatives [PDF]
ToxinsDatura species have been recognized for their potent pharmacological properties, producing a diverse array of tropane and non-tropane alkaloids with significant clinical and toxicological relevance.
Amin Mahmood Thawabteh +6 more
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Datura metel and Alcohol Cocktail Potentiates Hepatic Encephalopathy by Exacerbating Impairment via the Hepato-Prefrontal Cortical Axis [PDF]
Journal of PharmacopunctureObjectives: Substance abuse among adolescents is a major concern not only in developing countries but also worldwide. Datura metel (D. metel), commonly known as Datura or Devil’s Trumpet, is a plant containing several toxic compounds, including alkaloids
Ephraim Samuel Jen +5 more
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Behavioral and Biochemical Effects of an Arylhydrazone Derivative of 5-Methoxyindole-2-Carboxylic Acid in a Scopolamine-Induced Model of Alzheimer’s Type Dementia in Rats [PDF]
MoleculesAlzheimer’s disease (AD) has long proven to be a complex neurodegenerative disorder, with cholinergic dysfunction, oxidative stress, and neuroinflammation being just a few of its pathological features.
Polina Petkova-Kirova +11 more
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Antiamnestic effect of new nicotinic acid derivatives [PDF]
Research Results in Pharmacology, 2021 Introduction: The search for new drugs for the prevention and treatment of vascular cognitive disorders continues to be a relevant task of pharmacology.
Victor V. Yasnetsov +3 more
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Atropine and Scopolamine in Maize Products from the Retail Stores in the Republic of Serbia
Toxins, 2022 The cereal grains, which represent the cultivated grasses fruits, supply almost half of the total caloric requirements for humans and provide more nourishment compared with any other class of the food.
Gorica Vuković +11 more
doaj +1 more source