Results 11 to 20 of about 3,294 (199)

Antiamnestic effect of new nicotinic acid derivatives [PDF]

Research Results in Pharmacology, 2021
Introduction: The search for new drugs for the prevention and treatment of vascular cognitive disorders continues to be a relevant task of pharmacology.
Victor V. Yasnetsov, Diana E. Kaurova, Sofia Ya. Skachilova, Evgeniy Yu. Bersenev   +3 more
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Atropine and Scopolamine in Maize Products from the Retail Stores in the Republic of Serbia

Toxins, 2022
The cereal grains, which represent the cultivated grasses fruits, supply almost half of the total caloric requirements for humans and provide more nourishment compared with any other class of the food.
Gorica Vuković, Tijana Stojanović, Bojan Konstantinović, Vojislava Bursić, Nikola Puvača, Milena Popov, Nataša Samardžić, Aleksandra Petrović, Dušan Marinković, Svetlana Roljević Nikolić, Rada Đurović Pejčev, Bojana Špirović Trifunović   +11 more
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Thermal (In)stability of Atropine and Scopolamine in the GC-MS Inlet

Toxics, 2021
The intoxication due to unintentional or intentional ingestion of plant material containing tropane alkaloids is quite frequent. GC-MS method is still widely used for the identification of these toxicologically important substances in human specimen ...
Gordana Koželj, Helena Prosen
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Neuroprotective Effect of Yucca schidigera Roezl ex Ortgies Bark Phenolic Fractions, Yuccaol B and Gloriosaol A on Scopolamine-Induced Memory Deficits in Zebrafish

Molecules, 2022
Y. schidigera contains a number of unusual polyphenols, derivatives of resveratrol and naringenin, called spiro-flavostilbenoids, which have potent in vitro anti-inflammatory, antioxidant, and moderate cholinesterase inhibitory activities. To date, these
Łukasz Pecio, Solomiia Kozachok, Ion Brinza, Razvan Stefan Boiangiu, Lucian Hritcu, Cornelia Mircea, Ana Flavia Burlec, Oana Cioanca, Monica Hancianu, Olga Wronikowska-Denysiuk, Krystyna Skalicka-Woźniak, Wiesław Oleszek   +11 more
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Discovery of Novel Tryptanthrin Derivatives with Benzenesulfonamide Substituents as Multi-Target-Directed Ligands for the Treatment of Alzheimer’s Disease

Pharmaceuticals, 2023
Based on the multi-target-directed ligands (MTDLs) approach, two series of tryptanthrin derivatives with benzenesulfonamide substituents were evaluated as multifunctional agents for the treatment of Alzheimer’s disease (AD).
Guoxing Wang, Jiyu Du, Jie Ma, Peipei Liu, Siqi Xing, Jucheng Xia, Shuanghong Dong, Zeng Li   +7 more
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Anxiolytic, Promnesic, Anti-Acetylcholinesterase and Antioxidant Effects of Cotinine and 6-Hydroxy-L-Nicotine in Scopolamine-Induced Zebrafish (Danio rerio) Model of Alzheimer’s Disease

Antioxidants, 2021
Cotinine (COT) and 6-hydroxy-L-nicotine (6HLN) are two nicotinic derivatives that possess cognitive-improving abilities and antioxidant properties in different rodent models of Alzheimer’s disease (AD), eluding the side-effects of nicotine (NIC), the ...
Razvan Stefan Boiangiu, Marius Mihasan, Dragos Lucian Gorgan, Bogdan Alexandru Stache, Lucian Hritcu   +4 more
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Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Alzheimer’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry
Butyrylcholinesterase (BuChE) and neuroinflammation have recently emerged as promising therapeutic directions for Alzheimer’s disease (AD). Herein, we synthesised 19 novel pyranone-carbamate derivatives and evaluated their activities against ...
Chuanyu Yu, Xueyan Liu, Bingxiang Ma, Jiexin Xu, Yiquan Chen, Chaoxian Dai, Huaping Peng, Daijun Zha   +7 more
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Preparation of 4-Flexible Amino-2-Arylethenyl-Quinoline Derivatives as Multi-Target Agents for the Treatment of Alzheimer’s Disease

Molecules, 2018
Alzheimer’s disease (AD) is a complex and multifactorial neurodegenerative disorder of aged people. The development of multitarget-directed ligands (MTDLs) to act as multifunctional agents to treat this disease is the mainstream of current research.
Xiao-Qin Wang, Chu-Ping Zhao, Long-Cheng Zhong, De-Ling Zhu, De-Hao Mai, Mei-Gui Liang, Ming-Hua He   +6 more
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Investigation of Antistress and Antidepressant Activities of Synthetic Curcumin Analogues: Behavioral and Biomarker Approach

Biomedicines, 2022
Depression is a serious psychiatric disorder that affects millions of individuals all over the world, thus demanding special attention from researchers in order to investigate its effective remedies.
Haya Hussain, Shujaat Ahmad, Syed Wadood Ali Shah, Abid Ullah, Mazen Almehmadi, Osama Abdulaziz, Mamdouh Allahyani, Ahad Amer Alsaiari, Mustafa Halawi, Edrous Alamer   +9 more
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New Myrtenal–Adamantane Conjugates Alleviate Alzheimer’s-Type Dementia in Rat Model

Molecules, 2022
Alzheimer’s disease (AD) is a neurodegenerative disease associated with memory impairment and other central nervous system (CNS) symptoms. Two myrtenal–adamantane conjugates (MACs) showed excellent CNS potential against Alzheimer’s models.
Stela Dragomanova, Maria Lazarova, Aldar Munkuev, Evgeniy Suslov, Konstantin Volcho, Nariman Salakhutdinov, Amina Bibi, Jóhannes Reynisson, Elina Tzvetanova, Albena Alexandrova, Almira Georgieva, Diamara Uzunova, Miroslava Stefanova, Reni Kalfin, Lyubka Tancheva   +14 more
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