Results 11 to 20 of about 627,170 (198)

Flavonoid Derivatives as Potential Cholinesterase Inhibitors in Scopolamine-Induced Amnesic Mice: An In Vitro, In Vivo and Integrated Computational Approach

Brain Sciences, 2022
Flavonoids are one of the most exciting types of phenolic compounds with a wide range of bioactive benefits. A series of flavone derivatives (F1–F5) were previously synthesized from substituted O-hydroxy acetophenone and substituted chloro-benzaldehydes.
Fakhria A. Al-Joufi, Syed Wadood Ali Shah, Mohammad Shoaib, Mehreen Ghias, Shafiullah, Atif Ali Khan Khalil, Syed Babar Jamal, Syed Muhammad Hassan Shah, Muhammad Zahoor   +8 more
doaj   +3 more sources

Vanillin derivatives as antiamnesic agents in scopolamine-induced memory impairment in mice

Heliyon
Amnesia is a major health problem prevalent in almost every part of the world specifically in old age peoples. Vanillin analogues have played an important role in the field medicines.
Qamar Gul, Nasiara Karim, Mohammad Shoaib, Muhammad Zahoor, Mehboob Ur Rahman, Hayat Bilal, Riaz Ullah, Amal Alotaibi   +7 more
doaj   +3 more sources

The Ameliorating Effect of Phenylsulfonamide Derivatives on Scopolamine-Induced Memory Impairment in Mice via Inhibition of mPGES-1 [PDF]

Proceedings, 2019
Our previous research showed that a novel series of phenylsulfonyl hydrazide derivatives reduced LPS-induced PGE2 levels in RAW 264.7 macrophage cells via an inhibition of mPGES-1 enzyme. As a continuous work, new phenylsulfonamide derivatives (5a-5k) as
Ki Deok Ryu, Yoon Hyoung Moon, Do Hyeong Ko, Kyung-Tae Lee, Jae Yeol Lee   +4 more
doaj   +2 more sources

Scopolamine Derivatives as Potential Pharmaceuticals with Calixarene-CyclodextrineNanosponges as Drug Carriers [PDF]

, 2017
Tropane alkaloids are molecules with a strong biological activity, which are mainly produced by the members offamily Solanaceae, but also found inother plant families (Convolvulaceae, Brasicaceae, Erythroxylaceae andEuphorbiaceae).1 More than 20 active pharmaceutical substances containingthetropane moiety have been industrially produced and applied as ...
G. Rizzo, G. Catinella, S. Rosselli, P. Lo Meo, M. Bruno   +4 more
openaire   +1 more source

The memory ameliorating effects of novel N-benzyl pyridine-2-one derivatives on scopolamine-induced cognitive deficits in mice

Laboratory Animal Research
Background Alzheimer's disease (AD), the most common form of progressive dementia in the elderly, is a chronic neurological disorder that decreases cognitive ability.
Swati Pant, Mohan Gupta, Tulika Anthwal, Monika Chauhan, Sumitra Nain   +4 more
doaj   +3 more sources

Neuroprotective Effect of Yucca schidigera Roezl ex Ortgies Bark Phenolic Fractions, Yuccaol B and Gloriosaol A on Scopolamine-Induced Memory Deficits in Zebrafish

Molecules, 2022
Y. schidigera contains a number of unusual polyphenols, derivatives of resveratrol and naringenin, called spiro-flavostilbenoids, which have potent in vitro anti-inflammatory, antioxidant, and moderate cholinesterase inhibitory activities. To date, these
Łukasz Pecio, Solomiia Kozachok, Ion Brinza, Razvan Stefan Boiangiu, Lucian Hritcu, Cornelia Mircea, Ana Flavia Burlec, Oana Cioanca, Monica Hancianu, Olga Wronikowska-Denysiuk, Krystyna Skalicka-Woźniak, Wiesław Oleszek   +11 more
doaj   +1 more source

Investigation of Antistress and Antidepressant Activities of Synthetic Curcumin Analogues: Behavioral and Biomarker Approach

Biomedicines, 2022
Depression is a serious psychiatric disorder that affects millions of individuals all over the world, thus demanding special attention from researchers in order to investigate its effective remedies.
Haya Hussain, Shujaat Ahmad, Syed Wadood Ali Shah, Abid Ullah, Mazen Almehmadi, Osama Abdulaziz, Mamdouh Allahyani, Ahad Amer Alsaiari, Mustafa Halawi, Edrous Alamer   +9 more
doaj   +1 more source

Discovery of Novel Tryptanthrin Derivatives with Benzenesulfonamide Substituents as Multi-Target-Directed Ligands for the Treatment of Alzheimer’s Disease

Pharmaceuticals, 2023
Based on the multi-target-directed ligands (MTDLs) approach, two series of tryptanthrin derivatives with benzenesulfonamide substituents were evaluated as multifunctional agents for the treatment of Alzheimer’s disease (AD).
Guoxing Wang, Jiyu Du, Jie Ma, Peipei Liu, Siqi Xing, Jucheng Xia, Shuanghong Dong, Zeng Li   +7 more
doaj   +1 more source

Effects of scopolamine on matching to sample paradigm and related tests in human subjects [PDF]

, 2003
This was a double-blind placebo-controlled study with a cross-over design to examine the effects of scopolamine on cognitive functions in young healthy subjects.
Engel, R., Adam, M., Soyka, Michael, Koller, G., Kathmann, N., Satzger, W., Wagner, M.   +6 more
core   +1 more source

Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure [PDF]

, 2018
Trace conditioning is impaired by lesions to dorsal hippocampus, as well as by treatment with the muscarinic acetylcholine antagonist scopolamine. However, the role of muscarinic receptors within hippocampus has received little attention.
Hayley J. Marshall, Helen J. Cassaday, Marshall, Hayley J., Marie A. Pezze, Cassaday, Helen J., Pezze, Marie A.   +5 more
core   +1 more source