Results 21 to 30 of about 3,294 (199)

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Discovery of benzamide-hydroxypyridinone hybrids as potent multi-targeting agents for the treatment of Alzheimer's disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A novel class of benzamide-hydroxypyridinone (HPO) derivatives were innovatively designed, synthesised, and biologically evaluated as potential multitargeting candidates for the treatment of Alzheimer's disease (AD) through pharmacophores-merged ...
Xiaoying Jiang, Jianan Guo, Changjun Zhang, Jinping Gu, Tao Zhou, Renren Bai, Yuanyuan Xie   +6 more
doaj   +1 more source

Nitric Oxide-Dependent Mechanisms Underlying MK-801- or Scopolamine-Induced Memory Dysfunction in Animals: Mechanistic Studies

, 2021
MK-801, an NMDA receptor antagonist, and scopolamine, a cholinergic receptor blocker, are widely used as tool compounds to induce learning and memory deficits in animal models to study schizophrenia or Alzheimer-type dementia (AD), respectively.
Anna Siekierzycka, Leszek Kalinowski, Agata Płoska, Grzegorz Burnat, Paulina Cieślik, Adrianna Radulska, Piotr Brański, Joanna M. Wierońska   +7 more
core   +1 more source

Development of naringenin-O-alkylamine derivatives as multifunctional agents for the treatment of Alzheimer’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
In this study, a series of naringenin-O-alkylamine derivatives were designed and obtained by introducing an alkylamine fragment into the naringenin skeleton.
Jing Yang, Yi Zhou, Yujuan Ban, Jing Mi, Ying He, Xinjuan Li, Zhengwei Liu, Keren Wang, Gaofeng Zhu, Wenmin Liu, Zhenghuai Tan, Zhipei Sang   +11 more
doaj   +1 more source

Rg3-enriched ginseng extract ameliorates scopolamine-induced learning deficits in mice [PDF]

, 2016
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give ...
Ki Won Lee, Jin Hee Lee, Shim, Jaesung, Lee, Jin Hee, Siyoung Lee, Kim, Jiyoung, Lee, Siyoung, Lee, Hyong Joo, Jaesung Shim, Eunyoung Hong, Han, Jung-Soo, Cho, Woo-Hyun, Jiyoung Kim, Hyong Joo Lee, Lee, Ki Won, Woo-Hyun Cho, Jung-Soo Han, Hong, Eunyoung   +17 more
core   +1 more source

Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cholinesterase inhibitor plays an important role in the treatment of patients with Alzheimer’s disease (AD). Herein, we report the medicinal chemistry efforts leading to a new series of 1,3-dimethylbenzimidazolinone derivatives.
Jun Mo, Tingkai Chen, Hongyu Yang, Yan Guo, Qi Li, Yuting Qiao, Hongzhi Lin, Feng Feng, Wenyuan Liu, Yao Chen, Zongliang Liu, Haopeng Sun   +11 more
doaj   +1 more source

Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine [PDF]

Biological Psychiatry, 2018
Brain-derived neurotrophic factor (BDNF) plays a key role in the pathophysiology and treatment of depression. Recent clinical studies demonstrate that scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces rapid antidepressant effects in patients with depression.
Sriparna, Ghosal, Eunyoung, Bang, Wenzhu, Yue, Brendan D, Hare, Ashley E, Lepack, Matthew J, Girgenti, Ronald S, Duman   +6 more
openaire   +2 more sources

Oral Administration of Egg- and Soy-Derived Lysophosphatidylcholine Mitigated Acetylcholine Depletion in the Brain of Scopolamine-Treated Rats

Nutrients, 2023
Enzyme-modified lecithin that contains lysophosphatidylcholine (LPC) is generally recognized as safe. However, its potential as a functional ingredient has been less investigated than other choline (Ch)-containing compounds, such as glycerophosphocholine (GPC).
Ryohei Tanaka-Kanegae, Hiroyuki Kimura, Koichiro Hamada   +2 more
openaire   +2 more sources

Development of Ion‐selective Electrodes for Tropane, Atropine, and Scopolamine – A Concept for the Analysis of Tropane Alkaloids

, 2022
We present the development of novel ion-selective electrodes for tropane, atropine, and scopolamine, as a general model for tropane alkaloids and drugs such as e. g. cocaine.
Luger, Sebastian, Mayerhuber, Lisa, Weigelhofer, Gabriele, Hametner, Christian, Fruhmann, Philipp; orcid:, Hein, Thomas, Holzer, Brigitte; orcid:   +6 more
core   +1 more source

Enhanced Cognitive Effects of Demethoxycurcumin, a Natural Derivative of Curcumin on Scopolamine-Induced Memory Impairment in Mice [PDF]

Molecules, 2016
In the present study, we examined the ameliorating effects of demethoxycurcumin (DMC) on memory impairment induced by scopolamine using passive avoidance and Morris water maze tests in mice. Moreover, to determine the neurobiological effects underlying the ameliorating effects of the DMC, choline acetyltransferase (ChAT) immunoreactivity was evaluated ...
Dong Wook Lim, Hyun Jung Son, Min Young Um, In-Ho Kim, Daeseok Han, Suengmok Cho, Chang-Ho Lee   +6 more
openaire   +3 more sources