Targeting protein folding in N‐Myc‐driven medulloblastoma [PDF]
Molecular Oncology, 2023 Selective targeting of N‐Myc‐driven Sonic hedgehog (SHH) medulloblastoma has been a challenge for many years and, despite decades of research, few targeted therapy opportunities exist. Recently, Kuzuoglu‐Ozturk et al.
Gintvile Valinciute, Martine F. Roussel
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Computational completion of the Aurora interaction region of N-Myc in the Aurora a kinase complex [PDF]
Scientific Reports, 2023 Inhibiting protein–protein interactions of the Myc family is a viable pharmacological strategy for modulation of the levels of Myc oncoproteins in cancer. Aurora A kinase (AurA) and N-Myc interaction is one of the most attractive targets of this strategy
Pinar Altiner +3 more
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WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines [PDF]
Oncogenesis, 2023 Collectively, the MYC family of oncoprotein transcription factors is overexpressed in more than half of all malignancies. The ability of MYC proteins to access chromatin is fundamental to their role in promoting oncogenic gene expression programs in ...
Leigh A. Bumpous +12 more
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Disruption of the KLHL37–N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse models [PDF]
The Journal of Clinical InvestigationThe N-Myc gene MYCN amplification accounts for the most common genetic aberration in neuroblastoma and strongly predicts the aggressive progression and poor clinical prognosis.
Senfeng Xiang +15 more
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Interplay: The Essential Role between INSM1 and N-Myc in Aggressive Neuroblastoma [PDF]
Biology, 2022 An aggressive form of neuroblastoma (NB), a malignant childhood cancer derived from granule neuron precursors and sympathoadrenal lineage, frequently comprises MYCN amplification/elevated N-Myc expression, which contributes to the development of neural ...
Chiachen Chen, Michael S. Lan
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Shift of N-MYC Oncogene Expression in AML Patients Carrying the FLT3-ITD Mutation [PDF]
Pathophysiology, 2023 Mutations in the FLT3 gene not only lead to abnormalities in its structure and function, but also affect the expression of other genes involved in leukemogenesis.
Konstantin Bogdanov +7 more
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Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer [PDF]
Nature CommunicationsN-Myc is a key driver of neuroblastoma and neuroendocrine prostate cancer (NEPC). One potential way to circumvent the challenge of undruggable N-Myc is to target the protein homeostasis (proteostasis) system that maintains N-Myc levels. Here, we identify
Pengfei Xu +20 more
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Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus [PDF]
BMC GenomicsBackground During mitosis the cell depends on proper attachment and segregation of replicated chromosomes to generate two identical progeny. In cancers defined by overexpression or dysregulation of the MYC oncogene this process becomes impaired, leading ...
Sarah A. Streeter +9 more
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N-Myc and STAT Interactor is an Endometriosis Suppressor. [PDF]
Int J Mol SciIn patients with endometriosis, refluxed endometrial fragments evade host immunosurveillance, developing into endometriotic lesions. However, the mechanisms underlying this evasion have not been fully elucidated. N-Myc and STAT Interactor (NMI) have been identified as key players in host immunosurveillance, including interferon (IFN)-induced cell death
Park Y, Guan X, Han SJ.
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N-myc Modulates Expression of p73 in Neuroblastoma
Neoplasia: An International Journal for Oncology Research, 2002 The human p73 gene is a homolog of p53, which has been localized to chromosome 1p36 in a region that is frequently deleted in neuroblastoma. Transfection of the p73 gene into neuroblastoma cells that lack detectable p73 protein has been shown to result ...
Xiaoxiang Zhu +7 more
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