Results 11 to 20 of about 239,540 (278)

Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle [PDF]

Cell Reports, 2017
Summary: MYC proteins bind globally to active promoters and promote transcriptional elongation by RNA polymerase II (Pol II). To identify effector proteins that mediate this function, we performed mass spectrometry on N-MYC complexes in neuroblastoma ...
Gabriele Büchel, Anne Carstensen, Ka-Yan Mak, Isabelle Roeschert, Eoin Leen, Olga Sumara, Julia Hofstetter, Steffi Herold, Jacqueline Kalb, Apoorva Baluapuri, Evon Poon, Colin Kwok, Louis Chesler, Hans Michael Maric, David S. Rickman, Elmar Wolf, Richard Bayliss, Susanne Walz, Martin Eilers   +18 more
doaj   +5 more sources

The Expression and Localization of N-Myc Downstream-Regulated Gene 1 in Human Trophoblasts [PDF]

, 2013
The protein N-Myc downstream-regulated gene 1 (NDRG1) is implicated in the regulation of cell proliferation, differentiation, and cellular stress response.
A Fotovati, A Karaczyn, B Chen, B Xu, Baosheng Chen, CR Roh, D Pflueger, D Piquemal, DM Byers, DM Nelson, E Alsat, E Shaw, EA Mostaghel, Eric Y. Chuang, EU Jung, HJ Kliman, J Hwang, Jacob C. Larkin, JF Mouillet, JR Hickok, K Hirata, K Kokame, K Ogata, KJ Livak, KT Kim, L Aravind, L Kalaydjieva, LW Donaldson, M Hunter, M Hunter, MA Zoroddu, N van Belzen, NT Le, O Genbacev, P Lachat, RB Donker, RH King, RK Riemer, RP Caruso, S Bandyopadhyay, S Chen, S Sibold, S Smith, S Stein, SJ Choi, SK Kachhap, SK Kurdistani, T Fujii, T Matsugaki, T Mishima, T Okuda, T Sugiki, TM Lin, V Melotte, VM Banz, W Ulrix, WT Schaiff, X Qu, X Xu, Xiao-Hua Shi, Y Sadovsky, Y Sadovsky, Y Song, Y Taketomi, Y Zhou, Yoel Sadovsky, Z Chen, Z Kovacevic   +67 more
core   +13 more sources

SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. [PDF]

PLoS Genetics, 2011
The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting a low-level to a high-level N-Myc expression.
Glenn M Marshall, Pei Y Liu, Samuele Gherardi, Christopher J Scarlett, Antonio Bedalov, Ning Xu, Nuncio Iraci, Emanuele Valli, Dora Ling, Wayne Thomas, Margo van Bekkum, Eric Sekyere, Kacper Jankowski, Toby Trahair, Karen L Mackenzie, Michelle Haber, Murray D Norris, Andrew V Biankin, Giovanni Perini, Tao Liu   +19 more
doaj   +1 more source

Regulation der Genexpression von MYCN in humanen Neuoblastomzellen durch Transkriptionsfaktoren der E2F-Familie [PDF]

, 2005
Seit fast 30 Jahren ist bekannt, dass die Amplifikation und Expression des Onkogens MYCN in Neuroblastomen mit einer sehr ungünstigen Prognose für die Patienten einhergeht.
Eilers, Martin (Prof. Dr.), Kneppe, Verena   +1 more
core   +3 more sources

N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b. [PDF]

PLoS ONE, 2009
myc genes are best known for causing tumors when overexpressed, but recent studies suggest endogenous myc regulates pluripotency and self-renewal of stem cells.
Rebecca Cotterman, Paul S Knoepfler
doaj   +1 more source

N-myc Regulates Parkin Expression [PDF]

Journal of Biological Chemistry, 2004
Mutations in the parkin gene are common in early-onset and familial Parkinson's disease (PD), and the parkin protein interacts in the ubiquitin-proteasome system as an E3 ligase. However, the regulatory pathways that govern parkin expression are unknown. In this study, we showed that a phylogenetically conserved N-myc binding site in the bi-directional
Andrew B, West, Gregory, Kapatos, Casey, O'Farrell, Fanny, Gonzalez-de-Chavez, Kelvin, Chiu, Matthew J, Farrer, Nigel T, Maidment   +6 more
openaire   +2 more sources

N-Myc and GCN5 regulate significantly overlapping transcriptional programs in neural stem cells. [PDF]

PLoS ONE, 2012
Here we examine the functions of the Myc cofactor and histone acetyltransferase, GCN5/KAT2A, in neural stem and precursor cells (NSC) using a conditional knockout approach driven by nestin-cre.
Verónica Martínez-Cerdeño, Jessica M Lemen, Vanessa Chan, Alice Wey, Wenchu Lin, Sharon R Dent, Paul S Knoepfler   +6 more
doaj   +1 more source

Molecular Mechanisms of MYCN Dysregulation in Cancers

Frontiers in Oncology, 2021
MYCN, a member of MYC proto-oncogene family, encodes a basic helix-loop-helix transcription factor N-MYC. Abnormal expression of N-MYC is correlated with high-risk cancers and poor prognosis. Initially identified as an amplified oncogene in neuroblastoma
Ruochen Liu, Ruochen Liu, Ruochen Liu, Pengfei Shi, Pengfei Shi, Pengfei Shi, Zhongze Wang, Zhongze Wang, Chaoyu Yuan, Chaoyu Yuan, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui   +12 more
doaj   +1 more source

Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth [PDF]

Cell Death & Disease, 2012
Wig-1 is a transcriptional target of the p53 tumor suppressor and encodes an mRNA stability-regulating protein. We show here that Wig-1 knockdown causes a dramatic inhibition of N-Myc expression and triggers differentiation in neuroblastoma cells carrying amplified N-Myc. Transient Wig-1 knockdown significantly delays development of N-Myc-driven tumors
Vilborg, A, Bersani, C, Wickström, M, Segerström, L, Kogner, P, Wiman, K G   +5 more
openaire   +2 more sources

Liposomal delivery of hydrophobic RAMBAs provides good bioavailability and significant enhancement of retinoic acid signalling in neuroblastoma tumour cells [PDF]

, 2020
Retinoid treatment is employed during residual disease treatment in neuroblastoma, where the aim is to induce neural differentiation or death in tumour cells.
Bilip, Maja, Di Florio, Alessia, Eaton, Simon, Hart, Stephen L., Irving, Elsa, Maeshima, Ruhina, Mathiyalakan, Mayuran, Orford, Michael, Shah, Shreya, Simons, Claire, Stoker, Andrew W., Tagalakis, Aristides D.   +11 more
core   +4 more sources