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Correction for Wang et al., The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining. [PDF]

Proc Natl Acad Sci U S A
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Abstract 3027: SIRT1 promotes N-Myc oncogenesis stabilizing N-Myc protein

Cancer Research, 2011
Abstract The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting low-level to high-level N-Myc expression. N-Myc protein is stabilized when phosphorylated at Serine 62 by phosphorylated ERK protein.
Glenn M. Marshall, Pei Y. Liu, Samuele Gherardi, Christopher J. Scarlett, Antonio Bedalov, Ning Xu, Nunzio Iraci, Karen L. MacKenzie, Michelle Haber, Murray D. Norris, Andrew V. Biankin, Giovanni Perini, Tao Liu   +12 more
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N-myc transcription molecule and oncoprotein

The International Journal of Biochemistry & Cell Biology, 2004
N-myc has emerged as a member of a transcriptional regulatory network which impinges directly on the machinery of cell growth and proliferation. Critical during neural crest embryogenesis, N-myc is rapidly down-regulated as tissues become terminally differentiated and growth-arrested.
Wayne D, Thomas, Anna, Raif, Loen, Hansford, Glenn, Marshall   +3 more
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Paratesticular neuroblastoma with N-myc activation

Journal of Pediatric Surgery, 1993
The authors describe a case of disseminated neuroblastoma discovered as a paratesticular tumor in a 7-month-old boy. The ectopic adrenal tissues adjacent to the paratesticular tumor and multiple lesions in the adrenal gland and skin suggested the possibility of multifocal primary tumors. Although infantile neuroblastoma diagnosed at less than 1 year of
T, Matsunaga, H, Takahashi, N, Ohnuma, M, Tanabe, H, Yoshida, H, Enomoto, H, Horie, H, Shirasawa, B, Simizu   +8 more
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N-myc oncogene amplification in paediatric tumours

Irish Journal of Medical Science, 1990
DNA, extracted from tumours arising in 29 paediatric patients [14 neuroblastoma, 9 Wilms tumour (nephroblastoma), 6 miscellaneous] was investigated for evidence of N-myc amplification, using pNb-1, a recombinant plasmid containing a 1.0 Kb fragment homologous to the 5' end of the human N-myc gene.
S, McQuaid, A, O'Meara
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N-MYC overexpression and neuroblastomas

Trends in Pharmacological Sciences, 2002
In the advanced stages of human neuroblastomas, amplification of the N-MYC oncogene is a frequent event and correlates with poor prognosis and enhanced neovascularization. N-MYC amplification results in high N-MYC protein levels that can perturb the finely tuned interplay of N-MYC and MAX and could eventually induce abnormal expression patterns of ...
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N-myc Oncogene RNA Expression in Neuroblastoma

JNCI Journal of the National Cancer Institute, 1988
Tumor specimens from 33 patients with neuroblastoma were assayed for amplification of the N-myc oncogene and RNA expression to determine whether N-myc RNA expression levels correlated with N-myc gene amplification and clinical outcome. N-myc gene amplification was detected in one stage II tumor, one stage IV-S tumor, and seven stage III or IV tumors ...
P D, Nisen, P G, Waber, M A, Rich, S, Pierce, J R, Garvin, F, Gilbert, P, Lanzkowsky   +6 more
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N-myc Transactivates RCC1 Gene Expression in Rat Fibroblast Cells Transformed by N-myc and v-ras

Journal of Biochemistry, 1998
Oncogenic cooperation was found between the N-myc and v-ras oncogenes in a rat fibroblast cell line, 3Y1. To investigate the specific role of N-myc in the transformation, we established transformed cell lines that expressed N-myc under a controllable promoter.
M, Tsuneoka, E, Mekada
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N-myc functions in transcription and development

Birth Defects Research Part C: Embryo Today: Reviews, 2005
N-Myc is a member of the Myc family of proteins, which are best known for their potent oncogenic activities and association with a large proportion of human cancers. Intense scrutiny of the oncogenic properties of Myc family proteins over the last several decades has revealed a great deal about their transcriptional and oncogenic activities.
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N-Myc Shares Cellular Functions with c-Myc

DNA and Cell Biology, 2000
N-Myc is a member of the myc family of proto-oncogenes involved in initiation and progression of tumors. While c-MYC, the most characterized member of the family, is well known for its role in cellular proliferation and apoptosis, the function of N-MYC in differentiation and proliferation remains unclear.
S, Aubry, J, Charron
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