Results 31 to 40 of about 239,540 (278)

N-myc Down-Regulates Activin A

Biochemical and Biophysical Research Communications, 2000
N-myc oncogene amplification is frequent in human neuroblastoma and predicts poor prognosis, but the molecular consequences have remained obscure. We report here that enhanced N-myc expression correlates with low or undetectable expression of activin A, but not other closely related members of the transforming growth factor-beta superfamily.
Breit, Stephen, Rößler, Jochen, Fotsis, Theodore, Schweigerer, Lothar   +3 more
openaire   +4 more sources

N-myc and Noncoding RNAs in Neuroblastoma [PDF]

Molecular Cancer Research, 2012
Abstract Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Amplification and overexpression of the MYCN proto-oncogene occurs in approximately 20% of neuroblastomas and is associated with advanced stage disease, rapid tumor progression, and poor prognosis. MYCN encodes the transcriptional regulator N-myc, which has
Jochen, Buechner, Christer, Einvik
openaire   +2 more sources

N-Myc expression enhances the oncolytic effects of vesicular stomatitis virus in human neuroblastoma cells

Molecular Therapy: Oncolytics, 2016
N-myc oncogene amplification is associated but not present in all cases of high-risk neuroblastoma (NB). Since oncogene expression could often modulate sensitivity to oncolytic viruses, we wanted to examine if N-myc expression status would determine ...
Juan C Corredor, Nicole Redding, Karen Bloté, Stephen M Robbins, Donna L Senger, John C Bell, Paul Beaudry   +6 more
doaj   +1 more source

N-Myc knockdown and apigenin treatment controlled growth of malignant neuroblastoma cells having N-Myc amplification [PDF]

Gene, 2013
Malignant neuroblastomas mostly occur in children and are frequently associated with N-Myc amplification. Oncogene amplification, which is selective increase in copy number of the oncogene, provides survival advantages in solid tumors including malignant neuroblastoma.
Md Motarab, Hossain, Naren L, Banik, Swapan K, Ray   +2 more
openaire   +2 more sources

HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma [PDF]

Nature Medicine, 2016
The MYCN proto-oncogene is amplified in a number of advanced-stage human tumors, such as neuroblastomas. Similar to other members of the MYC family of oncoproteins, MYCN (also known as N-Myc) is a transcription factor, and its stability and activity are tightly controlled by ubiquitination-dependent proteasome degradation.
Tavana, Omid, Li, Dawei, Dai, Chao, Lopez, Gonzalo, Banerjee, Debarshi, Kon, Ning, Chen, Chao, Califano, Andrea, Yamashiro, Darrell J, Sun, Hongbin, Gu, Wei   +10 more
openaire   +2 more sources

C/EBPa controls acquisition and maintenance of adult hematopoietic stem cell quiescence [PDF]

, 2014
Summary In blood, transcription factor C/EBPa is essential for myeloid differentiation and has been implicated in regulating self-renewal of fetal liver (FL) hematopoietic stem cells (HSCs). However, its function in adult HSCs has remained unknown. Here,
Alberich-Jordà, Meritxell, Amabile, Giovanni, Kawasaki, Akira, Levantini, Elena, Staber, Philipp B., Tenen, Daniel G., Yang, Henry, Ye, Min, Zhang, Hong, Zhang, Junyan, Zhang, Pu   +10 more
core   +1 more source

Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin

Acta Dermato-Venereologica, 2018
Deregulated Hedgehog signalling is a driver of basal cell carcinomas. One effector of the Hedgehog pathway is n-MYC. c/n-MYC proteins, NAMPT and DBC1 are linked to SIRT1 in a positive feedback loop that may contribute to tumorigenesis of basal cell ...
Lydia Brandl, Daniela Hartmann, Thomas Kirchner, Antje Menssen   +3 more
doaj   +1 more source

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors [PDF]

, 2016
Myc family proteins promote cancer by inducing widespread changes in gene expression. Their rapid turn-over by the ubiquitin-proteasome pathway is regulated through phosphorylation of Myc Box I and ubiquitination by SCFFbxw7.
Bayliss, R, Burgess, S, Carstensen, A, Chesler, L, Eilers, M, Poon, E, Richards, MW   +6 more
core   +2 more sources

Mitoribosomal synthetic lethality overcomes multidrug resistance in MYC-driven neuroblastoma

Cell Death and Disease, 2023
Mitochondria are central for cancer responses to therapy-induced stress signals. Refractory tumors often show attenuated sensitivity to apoptotic signaling, yet clinically relevant molecular actors to target mitochondria-mediated resistance remain ...
Karolina Borankova, Maria Krchniakova, Lionel Y. W. Leck, Adela Kubistova, Jakub Neradil, Patric J. Jansson, Michael D. Hogarty, Jan Skoda   +7 more
doaj   +1 more source

Bcl-2 and N-Myc Coexpression Increases IGF-IR and Features of Malignant Growth in Neuroblastoma Cell Lines

Neoplasia: An International Journal for Oncology Research, 2001
The bcl-2 and c-myc oncogenes cooperate to transform multiple cell types. In the pediatric malignancy NB2, Bcl2 is highly expressed. In tumors with a poor prognosis, N-Myc, a protein homologous to c-Myc, is overexpressed as a result of gene amplification.
Rama Jasty, Cynthia {ptvan} Golen, Huey-Jen Lin, Gabe Solomon, Kathleen Heidelberger, Peter Polverini, Anthony Opipari, Eva Feldman, Valerie P. Castle   +8 more
doaj   +1 more source