Results 71 to 80 of about 239,540 (278)
Human Pathology: Case Reports, 2021 Two rare cases of large cell neuroblastoma (LCN) are reported. Case 1 (8-year-old male) showed the appearance of Neuroblastoma, poorly differentiated subtype with a high MKI (Mitosis-Karyorrhexis Index) and Case 2 (7-year-old male) was Neuroblastoma ...
Tamás Tornóczky +6 more
doaj +1 more source
Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells [PDF]
, 2015 This research was originally published in Journal of Biological Chemistry. Olesya Chayka, Cosimo Walter D’Acunto, Odette Middleton, Maryam Arab, and Arturo Sala.
Arab, M +4 more
core +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]
, 2012 Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone +2 more
core +2 more sources
NDRG1 protein overexpression in malignant thyroid neoplasms
Clinics, 2010 OBJECTIVES: The aim of this study was to examine the expression of the N-myc downstream-regulated gene 1 protein in benign and malignant lesions of the thyroid gland by immunohistochemistry.
Renê Gerhard +4 more
doaj +1 more source
Alternative approaches to target Myc for cancer treatment
Signal Transduction and Targeted Therapy, 2021 The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL, which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc, respectively.
Chen Wang +6 more
doaj +1 more source
A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis
Cell Reports, 2023 Summary: Refractory and relapsed B cell lymphomas are often driven by the difficult-to-target oncogene MYC. Here, we report that high MYC expression stimulates proliferation and protects B lymphoma cells from apoptosis under normal oxidative stress ...
Haidong Yao +10 more
doaj +1 more source
Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN-amplified retinoblastoma. [PDF]
, 2017 A small, but unique subgroup of retinoblastoma has been identified with no detectable mutation in the retinoblastoma gene (RB1) and with high levels of MYCN gene amplification.
Bhatti, Tricia R. +6 more
core +2 more sources
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Haematologica, 2023 The transcription factor MYC is a well-described oncogene with an important role in lymphomagenesis, but its significance for clinical outcome in mantle cell lymphoma (MCL) remains to be determined. We performed an investigation of the expression of MYC
Joana M. Rodrigues +15 more
doaj +1 more source