Risk assessment of N‐nitrosamines in food [PDF]
EFSA Journal, 2023 EFSA was asked for a scientific opinion on the risks to public health related to the presence of N‐nitrosamines (N‐NAs) in food. The risk assessment was confined to those 10 carcinogenic N‐NAs occurring in food (TCNAs), i.e. NDMA, NMEA, NDEA, NDPA, NDBA,
EFSA Panel on Contaminants in the Food Chain (EFSA CONTAM Panel) +24 more
doaj +6 more sources
N-nitrosamines in processed meats: Exposure, formation and mitigation strategies
Journal of Agriculture and Food Research, 2023 Nitrite and nitrate have been widely used in the preservation of meat products for the effective antimicrobial action against several pathogenic bacteria such as Clostridium botulinum, Salmonella and mesophilic bacteria.
Junfu Ji, Lingjun Ma, Yaqian Geng
exaly +4 more sources
Salmonella typhimurium TA100 and TA1535 and E. coli WP2 uvrA are highly sensitive to detect the mutagenicity of short Alkyl-N-Nitrosamines in the Bacterial Reverse Mutation Test [PDF]
Toxicology Reports, 2022 Humans are exposed to low levels of N-nitrosamines via different sources. N-Nitrosamines have recently been detected as impurities in various marketed drugs and they are known mutagenic carcinogens belonging to the cohort of concern as referred to in the
Frank Bringezu, Stephanie Simon
doaj +3 more sources
An Organic Chemist's Guide to N-Nitrosamines: Their Structure, Reactivity, and Role as Contaminants. [PDF]
J Org Chem, 2021 N-Nitrosamines are a class of compounds notorious both for the potent carcinogenicity of many of its members and for their widespread occurrence throughout the human environment, from air and water to our diets and drugs.
Beard JC, Swager TM.
europepmc +3 more sources
Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed. [PDF]
Int J Mol Sci, 2022 Carcinogenic N-nitrosamine contamination in certain drugs has recently caused great concern and the attention of regulatory agencies. These carcinogens—widely detectable in relatively low levels in food, water, cosmetics, and drugs—are well-established ...
Li Y, Hecht SS.
europepmc +2 more sources
Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines. [PDF]
Int J Mol Sci, 2022 The tobacco-specific N-nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco products or in environments contaminated by tobacco smoke.
Li Y, Hecht SS.
europepmc +2 more sources
Food Chemistry, 2022 Several epidemiological studies emphasize the consumption of processed meat products as a risk factor of colorectal cancer, linking N-nitrosamines (NAs) formed during nitrite curing to this cancer risk.
Susan Strange Herrmann, M Jakobsen
exaly +2 more sources
Absolute Quantitation of N-Nitrosamines by Coulometric Mass Spectrometry without Using Standards. [PDF]
J Am Soc Mass Spectrom, 2022 Carcinogenic N-nitrosamines were recently found in the sartan family of drugs and caused many drug recalls. Both of their detection and quantification are therefore important.
Wang Q, Liu Z, Liu Y, Chen H.
europepmc +2 more sources
Residual Nitrite, Nitrate, and Volatile N-Nitrosamines in Organic and Conventional Ham and Salami Products [PDF]
FoodsNitrite and nitrate in meat products may be perceived negatively by consumers. These compounds can react to form carcinogenic volatile N-nitrosamines.
Kathrine H. Bak +3 more
doaj +2 more sources
The Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence [PDF]
Current Oncology, 2022 Deregulation of the DNA mismatch repair (MMR) mechanism has been linked to poor prognosis of upper aerodigestive tract cancers. Our recent in vitro data have provided evidence of crosstalk between deregulated miRNAs and MMR genes, caused by tobacco smoke
Sotirios G. Doukas +5 more
doaj +2 more sources