Risk assessment of N‐nitrosamines in food [PDF]
EFSA Journal, 2023 EFSA was asked for a scientific opinion on the risks to public health related to the presence of N‐nitrosamines (N‐NAs) in food. The risk assessment was confined to those 10 carcinogenic N‐NAs occurring in food (TCNAs), i.e. NDMA, NMEA, NDEA, NDPA, NDBA,
EFSA Panel on Contaminants in the Food Chain (EFSA CONTAM Panel) +24 more
doaj +5 more sources
Salmonella typhimurium TA100 and TA1535 and E. coli WP2 uvrA are highly sensitive to detect the mutagenicity of short Alkyl-N-Nitrosamines in the Bacterial Reverse Mutation Test [PDF]
Toxicology Reports, 2022 Humans are exposed to low levels of N-nitrosamines via different sources. N-Nitrosamines have recently been detected as impurities in various marketed drugs and they are known mutagenic carcinogens belonging to the cohort of concern as referred to in the
Frank Bringezu, Stephanie Simon
doaj +2 more sources
Lipid metabolism disorders contribute to hepatotoxicity of ICR mice induced by nitrosamines exposure
Environment International, 2022 Health risks caused by crucial environmental carcinogens N-nitrosamines triggered ubiquitous attention. As the liver exerted vital function through metabolic process, lipid metabolism disorders have been confirmed as potential drivers for toxicological ...
Lihong Yin, Shizhi Wang, Yuepu Pu
exaly +3 more sources
Residual Nitrite, Nitrate, and Volatile N-Nitrosamines in Organic and Conventional Ham and Salami Products [PDF]
FoodsNitrite and nitrate in meat products may be perceived negatively by consumers. These compounds can react to form carcinogenic volatile N-nitrosamines.
Kathrine H. Bak +3 more
doaj +2 more sources
N-Nitrosamine Impurities in Ethalfluralin: Determination of an Overlooked Deleterious Source in Pesticides [PDF]
Agriculture, 2023 N-nitrosamines are a class of carcinogenic chemical compound. Considering the large-scale application of agrochemicals globally, the elimination of N-nitrosamines from pesticides should be a priority for manufacturers and regulators. A set of methods was
George P. Balayiannis, Helen Karasali
doaj +2 more sources
The Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence [PDF]
Current Oncology, 2022 Deregulation of the DNA mismatch repair (MMR) mechanism has been linked to poor prognosis of upper aerodigestive tract cancers. Our recent in vitro data have provided evidence of crosstalk between deregulated miRNAs and MMR genes, caused by tobacco smoke
Sotirios G. Doukas +5 more
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Dietary exposure to N-nitrosamines and their precursors: an age-stratified assessment [PDF]
Scientific ReportsDietary exposure to N-nitrosamines (N-NAs) may pose health concerns across all age groups, particularly in children and the elderly, due to their association with increased cancer risk.
Aida Zapico +5 more
doaj +2 more sources
Inhibition effect of non-contact biocontrol bacteria and plant essential oil mixture on the generation of N-nitrosamines in deli meat during storage [PDF]
Food Chemistry: XTo reduce the risk of N-nitrosamines in deli meat products, this study formulated a novel non-contact N-nitrosamines inhibiting preservative IV (NIP-IV) consisting of biocontrol bacteria and plant essential oils (EOs) (Stenotrophomonas rhizophila SR-1 ...
Ke Li +9 more
doaj +2 more sources
Distribution of Seven N-Nitrosamines in Food. [PDF]
Toxicol Res, 2015 N-nitrosamines, which are classified as carcinogens by IARC and US EPA, can be easily found in various foods. They are reaction products between nitrogen oxide and secondary amines, but can also be generated during fermentation. Ever since the 1960s, when nitrite, used as a preservative in processed meats, was suspected to generate N-nitrosamines, the ...
Park JE, Seo JE, Lee JY, Kwon H.
europepmc +4 more sources
Resolution of historically discordant Ames test negative/rodent carcinogenicity positive N-nitrosamines using a sensitive, OECD-aligned design. [PDF]
MutagenesisThomas DN +12 more
europepmc +3 more sources