Results 21 to 30 of about 27,815,460 (250)
Determination of dietary exposure and extraction efficiency of nitrosamine from cooked meat
Current Research in Food Science, 2022 Meat products are claimed to be a source of carcinogenic nitrosamines (NAs) exposure in food. In this study, dietary exposure of six nitrosamines: N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA), N-nitrosopyrrolidine (NPYR), N ...
Abu Tareq Mohammad Abdullah +4 more
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环境与职业医学, 2022 BackgroundN-nitrosamines, a group of by-products of drinking water disinfection, have strong cytotoxicity to mammals. N-nitrosamines in drinking water are at the ng·L−1 level, and its accurate qualitative and quantitative analysis is difficult, so it is ...
Dengkun LI +5 more
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Science of the Total Environment, 2023 The discharge of substantial amounts of N-nitrosamines-contained wastewater into receiving rivers can significantly deteriorate water quality, as these carcinogenic compounds can be easily transported into groundwater and drinking water systems.
Wen-Wen Chen +9 more
semanticscholar +1 more source
Lipid metabolism disorders contribute to hepatotoxicity of ICR mice induced by nitrosamines exposure
Environment International, 2022 Health risks caused by crucial environmental carcinogens N-nitrosamines triggered ubiquitous attention. As the liver exerted vital function through metabolic process, lipid metabolism disorders have been confirmed as potential drivers for toxicological ...
Hu Zhang +9 more
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Permitted daily exposure limits for noteworthy N‐nitrosamines
Environmental and Molecular Mutagenesis, 2021 A genotoxic carcinogen, N‐nitrosodimethylamine (NDMA), was detected as a synthesis impurity in some valsartan drugs in 2018, and other N‐nitrosamines, such as N‐nitrosodiethylamine (NDEA), were later detected in other sartan products.
George E. Johnson +11 more
semanticscholar +1 more source
Use of the bacterial reverse mutation assay to predict carcinogenicity of N-nitrosamines.
Regulatory toxicology and pharmacology : RTP, 2022 Under ICH M7, impurities are assessed using the bacterial reverse mutation assay (i.e., Ames test) when predicted positive using in silico methodologies followed by expert review.
A. Trejo-Martin +18 more
semanticscholar +1 more source
The EU Response to the Presence of Nitrosamine Impurities in Medicines
Frontiers in Medicine, 2021 The unexpected detection of nitrosamine impurities in human medicines has recently seen global regulators act to understand the risks of these contaminations to patients and to limit their presence.
Robin Ruepp +7 more
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Nitrosamines: A review of formation pathways, precursors, control, and occurrence in drinking water [PDF]
MATEC Web of Conferences, 2019 Nitrogenous disinfection by-products (N-DBPs) are emerging by-products that may be present in drinking water as by-products of water treatment plant (WTP) operations.
Meadows Maxwell +3 more
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Shipin gongye ke-ji, 2023 Based on the emulsification/demulsification method, a gas chromatography tandem mass spectrometry method was established for the quantitative determination of 12 nitrosamines in milk.
Wenfeng TONG +3 more
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