Results 31 to 40 of about 25,317 (180)

The comparative population genetics of Neisseria meningitidis and Neisseria gonorrhoeae [PDF]

PeerJ, 2019
Neisseria meningitidis and N. gonorrhoeae are closely related pathogenic bacteria. To compare their population genetics, we compiled a dataset of 1,145 genes found across 20 N. meningitidis and 15 N. gonorrhoeae genomes. We find that N.
Lucile Vigué, Adam Eyre-Walker
doaj   +2 more sources

Neisseria gonorrhoeae lipooligosaccharide glycan epitopes recognized by bactericidal IgG antibodies elicited by the meningococcal group B-directed vaccine, MenB-4C

Frontiers in Immunology
IntroductionOuter membrane vesicles (OMVs) of Neisseria meningitidis in the group B-directed vaccine MenB-4C (BexseroR) protect against infections with Neisseria gonorrhoeae. The immunological basis for protection remains unclear. N.
Yih-Ling Tzeng, Soma Sannigrahi, Ray Borrow, David S. Stephens, David S. Stephens   +4 more
doaj   +1 more source

Asymptomatic carriers of Neisseria meningitidis and Moraxella catarrhalis in healthy children

New Microbes and New Infections, 2020
There is a close correlation between asymptomatic oropharyngeal colonization by bacterial pathogens and paediatric respiratory diseases. Evaluation of the frequency of asymptomatic carriers of Neisseria meningitidis and Moraxella catarrhalis in healthy ...
A. Maleki, Z. Mirnaseri, E. Kouhsari, M. Taherikalani, I. Pakzad, J. Mohammadi, N. Sadeghifard   +6 more
doaj   +1 more source

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Susceptibility of Neisseria meningitidis and Neisseria gonorrhoeae isolates to N-formimidoyl thienamycin [PDF]

Antimicrobial Agents and Chemotherapy, 1982
A diverse collection of 123 meningococcal and 126 gonococcal isolates was tested for susceptibility to N-formimidoyl thienamycin (N-F-thienamycin; MK0787) and to penicillin G (PEN). All of the meningococci were susceptible to both of these, as well as to rifampin.
E J, Dudek, J D, Stephenson, M, Bohnhoff, S A, Lerner   +3 more
openaire   +2 more sources

Analysis of the Recovery of Immune Status in the Patients With Paroxysmal Nocturnal Hemoglobinuria After Treatment With C5 Complement Inhibitor

Journal of Clinical Laboratory Analysis, EarlyView.
We retrospectively evaluated the impact of C5 complement inhibition on immune cell profiles and recovery in 27 PNH patients; both CD4+ and CD8+ T cells exhibited partial recovery, while B cell counts increased but remained below normal levels. In contrast, Treg cells were significantly reduced in PNH patients and showed no notable change post‐treatment.
Hui Liu, Mengting Che, Liyan Li, Honglei Wang, Chaomeng Wang, Junshu Wu, Yingying Chen, Zhaoyun Liu, Lijuan Li, Rong Fu   +9 more
wiley   +1 more source

Effect of penicillin and chloramphenicol on the growth and endotoxin release by N. meningitidis [PDF]

Epidemiology and Infection, 1991
SUMMARYThe action of two antibiotics, penicillin and chloramphenicol, on bacterial growth and endotoxin liberation was studied in 18 strains of Neissevia meningitidis isolated from blood and CSF of patients with meningococcal infections. The antibiotics were administered both separately and in combined form in doses equivalent to 1 MIC and 100 MIC ...
M C, Mellado, R, Rodríguez-Contreras, A, Mariscal, J D, Luna, M, Delgado Rodríguez, R, Galvez-Vargas   +5 more
openaire   +2 more sources

Greater Cochlear Damage in Otogenic Versus Meningogenic Meningitis: Hearing Rehabilitation Implications

The Laryngoscope, EarlyView.
Otogenic route of meningitis was associated with greater cochlear hair cell loss in comparison with the meningogenic one in this otopathology study. Neuronal depletion has been traditionally implicated in failed hearing rehabilitation of post‐meningitis deafness.
Matheus Pedrosa Tavares, Henrique Furlan Pauna, Rafael da Costa Monsanto, Nevra Keskin‐Yilmaz, Breno Lima de Almeida, Norma de Oliveira Penido   +5 more
wiley   +1 more source

Differential activation of acid sphingomyelinase and ceramide release determines invasiveness of Neisseria meningitidis into brain endothelial cells. [PDF]

PLoS Pathogens, 2014
The interaction with brain endothelial cells is central to the pathogenicity of Neisseria meningitidis infections. Here, we show that N. meningitidis causes transient activation of acid sphingomyelinase (ASM) followed by ceramide release in brain ...
Alexander Simonis, Sabrina Hebling, Erich Gulbins, Sibylle Schneider-Schaulies, Alexandra Schubert-Unkmeir   +4 more
doaj   +1 more source

The Host-Pathogen Interactions and Epicellular Lifestyle of Neisseria meningitidis

Frontiers in Cellular and Infection Microbiology, 2022
Neisseria meningitidis is a gram-negative diplococcus and a transient commensal of the human nasopharynx. It shares and competes for this niche with a number of other Neisseria species including N. lactamica, N. cinerea and N. mucosa.
August Mikucki, Nicolie R. McCluskey, Nicolie R. McCluskey, Charlene M. Kahler   +3 more
doaj   +1 more source