Results 21 to 30 of about 851 (135)

Pyrophosphate-mediated iron acquisition from transferrin in Neisseria meningitidis does not require TonB activity. [PDF]

open access: yesPLoS ONE, 2014
The ability to acquire iron from various sources has been demonstrated to be a major determinant in the pathogenesis of Neisseria meningitidis.
Francis Biville   +3 more
doaj   +1 more source

Kiss and Run – Phosphoglycerol Modifications of N. Meningitidis Pili Mediate Detachment [PDF]

open access: yesFrontiers in Microbiology, 2011
geneity with an increase in the number of residues bearing PG. They further report that inactivation of pptB and substitution of pilin serine residue 93 (a conserved and likely site of PG occupancy in strain 8013) led to an approximately two-fold increase in the number of bacteria found in aggregates.
Michael eKoomey   +3 more
openaire   +3 more sources

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

open access: yesAngewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster   +13 more
wiley   +2 more sources

Imunidade conferida por vacinas anti-meningocócicas Immunity confered by anti-meningococci vaccines

open access: yesRevista de Saúde Pública, 1993
Em razão da recente epidemia de doença meningocócica causada por N. meningitidis B na Grande São Paulo, Brasil, foi feita revisão das epidemias dessa doença ocorridas no Brasil desde o início do século e uma análise das vacinas atuais contra N ...
Lucimar Gonçalves Milagres   +1 more
doaj   +3 more sources

Nitro Reduction‐Based RNA Control and Ultrafast Release

open access: yesAngewandte Chemie, EarlyView.
A chemical RNA caging–uncaging strategy based on nitro reduction is described. Nitroaryl groups introduced via acylation temporarily block the functions of diverse RNAs in vitro and in living cells. Treatment with a diboronic acid–bipyridine mixture rapidly reduces the nitro groups, releasing RNAs and restoring their activity.
Yiran Zhao   +6 more
wiley   +2 more sources

In Silico Analysis of the Antigenic Properties of Iron-Regulated Proteins against Neisseria meningitidis

open access: yesApplied Sciences, 2020
Neisseria meningitidis is a commensal pathogen that causes infectious cerebrospinal disease in people of all ages. The multivariate role of six disease-causing polysaccharide serotypes is found to play a crucial role in developing vaccines (or general ...
Md. Shahedur Rahman   +6 more
doaj   +1 more source

The Susceptibility of Meningococci to the Antimicrobial Agents in Moscow 2006 - 2015

open access: yesЭпидемиология и вакцинопрофилактика, 2016
Relevance. One of the prognostic criteria meningococcal infection (MI) epidemic status process is the increasing number of resistant to antibiotics meningococcal strains.
M. A. Koroleva   +3 more
doaj   +1 more source

Deletion of D-Lactate Dehydrogenase A in Neisseria meningitidis Promotes Biofilm Formation Through Increased Autolysis and Extracellular DNA Release

open access: yesFrontiers in Microbiology, 2019
Neisseria meningitidis is a Gram-negative bacterium that asymptomatically colonizes the human nasopharyngeal mucosa. Pilus-mediated initial adherence of N. meningitidis to the epithelial mucosa is followed by the formation of three-dimensional aggregates,
Sara Sigurlásdóttir   +4 more
doaj   +1 more source

Improving the therapy of generalized forms of Meningococcal infection in children using extracorporeal hemocorrection

open access: yesДетские инфекции (Москва), 2021
Invasive meningococcal infection is a significant cause of death, reaching 80% in septic shock. The Pediatric Research and Clinical Center for Infectious Diseases (PRCCID) has developed an algorithm for the treatment of children with invasive ...
K. V. Markova   +8 more
doaj   +1 more source

Neisseria meningitidis pneumonia with bacteremia without meningitis: An atypical presentation

open access: yesIDCases, 2020
Neisseria meningitidis remains the most important cause of bacterial meningitis worldwide. The second most common and potentially severe end-organ manifestation of invasive meningococcal disease is meningococcal pneumonia.
Fatma Mohamed Mahmoud, Thana Harhara
doaj   +1 more source

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