Results 131 to 140 of about 17,313 (241)

The Potential Roles of RNA N6-Methyladenosine in Urological Tumors [PDF]

, 2020
Li Yang, Yu‐Zheng Ge, Luwei Xu, Zheng Xu, Quanliang Dou, Rui-Peng Jia   +5 more
openalex   +1 more source

hnRNPC Functions with HuR to Regulate Alternative Splicing in an m6A‐Dependent Manner and is Essential for Meiosis

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This work shows that hnRNPC recognizes and binds directly to key meiosis‐related genes and works with HuR to regulate alternative splicing of its target genes, ensuring the normal production and proper function of essential meiotic transcripts required for meiotic initiation and progression during the first wave of spermatogenesis.
Xinxin Xiong, Shenglei Feng, Xixiang Ma, Kuan Liu, Yiqian Gui, Bei Chen, Xu Fan, Fengli Wang, Xiaoli Wang, Shuiqiao Yuan   +9 more
wiley   +1 more source

HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine [PDF]

, 2019
Weili Miao, Lin Li, Yonghui Zhao, Xiaoxia Dai, Xuemei Chen, Yinsheng Wang   +5 more
openalex   +1 more source

N6-methyladenosine (m6A) modification in hepatocellular carcinoma

Biomedicine & Pharmacotherapy
Hepatocellular carcinoma (HCC) is one of the deadliest cancers of human, the tumor-related death of which ranks third among the common malignances. N6-methyladenosine (m6A) methylation, the most abundant internal modification of RNA in mammals, participates in the metabolism of mRNA and interrelates with ncRNAs. In this paper, we overviewed the complex
Hehua Ma, Yuxin Hong, Zhenzhen Xu, Zuyi Weng, Yuanxun Yang, Dandan Jin, Zhiyou Chen, Jing Yue, Xuan Zhou, Zhi Xu, Fei Fei, Juan Li, Wei Song   +12 more
openaire   +2 more sources

HDAC2‐Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple‐Negative Breast Cancer

Advanced Science, Volume 12, Issue 14, April 10, 2025.
This study identifies the lactylation modification of methyltransferase‐like 3 (METTL3) in breast tumors and its delactylase histone deacetylase 2 (HDAC2). It elucidates the molecular mechanism by which HDAC2‐mediated METTL3 delactylation promotes triple‐negative breast cancer (TNBC) resistance to cisplatin through upregulation of DNA damage repair ...
Xiaoniu He, Yuanpei Li, Jian Li, Yu Li, Sijie Chen, Xia Yan, Zhangrong Xie, Jiangfeng Du, Guoan Chen, Jianbo Song, Qi Mei   +10 more
wiley   +1 more source

Deoxyribozyme-based method for absolute quantification of N6-methyladenosine fractions at specific sites of RNA [PDF]

, 2020
Magda Bujnowska, Jiacheng Zhang, Qing Dai, Emily M. Heideman, Jingyi Fei   +4 more
openalex   +1 more source

Landscape of N6-Methyladenosine Modification Patterns in Human Ameloblastoma [PDF]

, 2020
Xing Niu, Jingping Xu, Jinwen Liu, Lijie Chen, Xue Qiao, Ming Zhong   +5 more
openalex   +1 more source

Science of omics: a molecular space odyssey

Experimental Physiology, EarlyView.
Salomé Coppens, Christophe Hirtz, Margaux Vignon, Damian M. Bailey   +3 more
wiley   +1 more source

METTL3, an Independent Adverse Prognostic Factor for AML, Promotes the Development of AML by Modulating the PGC‐1α–MAPK Pathway and PGC‐1α–Antioxidant System Axis

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background m6A represents a prevalent epigenetic modification of mammalian mRNAs. Studies have demonstrated that m6A RNA methylation‐modifying enzymes play crucial roles in the onset and progression of AML. However, their clinical relevance remains undefined, and the mechanisms underlying their modulation of AML have yet to be elucidated ...
Yuqian Tang, Xiaoyan Liu, Wu Ye, Xiaojia Wang, Xiaoyu Wei, Yiwen Du, Ying Zhang, Yuping Gong   +7 more
wiley   +1 more source

Faculty Opinions recommendation of N6-methyladenosine marks primary microRNAs for processing.

, 2015
Dorothy E. Shippen, Catherine Cifuentes‐Rojas   +1 more
openalex   +2 more sources