Results 171 to 180 of about 29,575 (253)

Melatonin‐engineered MSCs‐exosomes deliver USP4 to stabilise ARNTL and inhibit clock rhythmic ferroptosis for enhanced flap survival

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
• Sleep restriction induces clock rhythmic ferroptosis, leading to skin flap necrosis. • MEXOs deliver USP4 to stabilise ARNTL, restoring circadian rhythm and inhibiting ferroptosis. • The METTL3/YTHDF1 m6A axis up‐regulates USP4 in melatonin‐preconditioned BMSCs.
Xiaoqiong Jiang, Yu Wang, Xuanlong Zhang, Huiming Deng, Liangyu Fang, Chaire Tafadzwa, Jiangnan Yao, Hao Chen, Anqi Ye, Kailiang Zhou, Xiangwei Ling, Jian Xiao   +11 more
wiley   +1 more source

Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy [PDF]

, 2020
Gaocai Li, Yu Song, Zhiwei Liao, Kun Wang, Rongjin Luo, Saideng Lu, Kangcheng Zhao, Xiaobo Feng, Hang Liang, Liang Ma, Bingjin Wang, Wencan Ke, Huipeng Yin, Shengfeng Zhan, Shuai Li, Xinghuo Wu, Yukun Zhang, Yang Cao   +17 more
openalex   +1 more source

The Emerging Role of RNA N6-Methyladenosine Modification in Pancreatic Cancer [PDF]

, 2022
Xiaoge Hu, Xiangxiang Lei, Jinhui Guo, Wenbin Fu, Wen Sun, Qiliang Lu, Wei Su, Qiuran Xu, Kangsheng Tu   +8 more
openalex   +1 more source

Diabetic Kidney Disease Progression Alleviated in Mice by ALKBH5‐Mediated UC‐MSCs‐Derived Exosomes That Inhibit TRAF6 m6A Modification and Promote M2 Macrophage Polarisation

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
ALKBH5‐modified UC‐MSCs‐derived exosomes (OE‐ALKBH5 Exo) inhibit the expression of M1 markers (iNOS, IL‐1β, TNF‐α, CD86) and enhance the expression of M2 markers (IL‐10, Arg‐1, CD206) by inhibiting the m6A methylation of TRAF6 and reducing its protein level and stability, thereby promoting M2 polarisation and alleviating the progression of DKD ...
Lei Li, Hongmei Liu, Huanhuan Wang, Yu Mao, Lige Song, Zhiqiang Kang   +5 more
wiley   +1 more source

The N6-Methyladenosine (m6A) Methylation Gene YTHDF1 Reveals a Potential Diagnostic Role for Gastric Cancer

, 2020
Tingting Liu, S.Y. Cindy Yang, Cheng YP, Kong XL, Du DD, Xin Wang, Bai Yf, Yin LH, Pu YP, Liang Gy   +9 more
openalex   +1 more source

RBM15 Mediated m6A Modification of SRSF1 Inhibits Cuproptosis in Non‐Small Cell Lung Cancer by Mediating ATP7B Alternative Splicing

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 1, January 2026.
ABSTRACT Inhibition of cuproptosis contributes to the development of non‐small cell lung cancer (NSCLC). The expression of RNA‐binding motif protein 15 (RBM15) is upregulated in NSCLC. Nonetheless, its relationship with cuproptosis remains unclear. This study aimed to explore the role of RBM15 in regulating cuproptosis in NSCLC. A549 cells were treated
Shan‐shan Mao, Dong‐yu Wu, Rong‐hua Cui, Xiao‐zhen Cheng   +3 more
wiley   +1 more source

The mRNA N6-Methyladenosine Response to Dehydration in Xenopus laevis [PDF]

Saif Rehman, Mackenzie Parent, Kenneth B. Storey   +2 more
openalex   +1 more source

N6-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling [PDF]

, 2019
Abhirami Visvanathan, Vikas Patil, Shibla Abdulla, Jörg D. Hoheisel, Kumaravel Somasundaram   +4 more
openalex   +1 more source

YTHDC1 Orchestrates Telomerase Assembly via Scaffold‐Mediated TERT‐TERC Interaction

Aging Cell, Volume 25, Issue 1, January 2026.
Schematic illustration of the major findings: METTL3‐deposited m6A modifications on TERC recruit the reader protein YTHDC1, which functions as a molecular scaffold to facilitate telomerase holoenzyme assembly by bridging TERT to m6A‐modified TERC transcripts, thereby promoting the proliferation of AECs.
Xiaolei Cheng, Shixing Wang, Yanan Yu, Jianhang Xu, Qian Wang, Yuzhu Wei, Zeming Jin, Xinkun Qi, Dongdong Jian, Yingchao Shi, Zhen Li, Zhengliang Ma, Wengong Wang, Tianjiao Xia, Junyue Xing, Xiaoping Gu, Hao Tang   +16 more
wiley   +1 more source

PRKN‐Mediated Ubiquitin‐Proteasome Degradation of METTL3 Promotes Cellular Senescence

Aging Cell, Volume 25, Issue 1, January 2026.
Schematic diagram of model for PRKN mediate METTL3 proteasome degradation promoting cellular senescence. The left panel shows a high abundance of METTL3 expression in young cells. METTL3 mediates m6A modification on TRF2 and POT1 mRNA, leading to their high expression and maintaining telomere stability.
Liping Chen, Canfeng Zhang, Yuanlong Ge, Haoxian Zhou, Shenglong Yang, Wenjing Wei, Qinghua Zhou, Kaizhen Xiao, Guangyu Huang, Xiaocui Li, Jia Wang, Jinping Zheng, Ronghe Gu, Zhenyu Ju, Shu Wu   +14 more
wiley   +1 more source