Results 181 to 190 of about 28,700 (263)

Intranuclear paraspeckle‐circular RNA TACC3 assembly forms RNA‐DNA hybrids to facilitate MASH‐related hepatocellular carcinoma growth in an m6A‐dependent manner

Cancer Communications, Volume 45, Issue 11, Page 1583-1610, November 2025.
Abstract Background Metabolic dysfunction‐associated steatohepatitis (MASH) is anticipated to become the leading cause of hepatocellular carcinoma (HCC). Accumulating evidence indicates that N6‐methyladenosine (m6A)‐modified circular RNAs (circRNAs) play key roles in tumor malignant progression.
Jingbo Fu, Yanping Wei, Yun Yang, Xinwei Yang, Tao Ouyang, Xianming Wang, Shuzhen Chen, Zenglin Liu, Yu Su, Jing Fu, Miao Yu, Haihua Qian, Hao Song, Shuo Xu, Ru Zhao, Xue Jiang, Yunfei Huo, Man Zhang, Pinhua Yang, Zhao Yang, Kui Wang, Liang Li, Hongyang Wang   +22 more
wiley   +1 more source

Enhancing sensitivity of triple-negative breast cancer to DNA damaging therapy through chemical inhibition of the m6A methyltransferase METTL3 [PDF]

Among the different types of breast cancer, triple-negative breast cancer (TNBC) displays the most unfavourable prognosis and high risk of recurrence. Conventional chemotherapy and DNA damaging agents are the main treatment for this cancer. However, this
CESARO, BIANCA
core  

Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy

Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.
Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan, Ximin Tan, Bin Song, Ming Yi, Qian Chu, Kongming Wu   +5 more
wiley   +1 more source

Integrating Nature Into Oncology: Enhancing Hematological Malignancies Therapies With Natural Medicine

Cancer Medicine, Volume 14, Issue 21, November 2025.
ABSTRACT Hematological malignancies are complex clonal disorders that pose a significant threat to human health. Current treatment modalities, including radiotherapy, chemotherapy, immunotherapy, and bone marrow transplantation, have demonstrated efficacy but are often limited by side effects, drug resistance, and suboptimal cure rates.
Yaoyao Tian, Baoyi Ni, Dandan Cai, Jia Wang, Jilai Zhou, Mingqian Song, Xi Zhang, Jiakang Jiang   +7 more
wiley   +1 more source

m7G RNA methylation in cancer: Effect, mechanism and clinical application

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
m7G RNA methylation in cancer. m7G regulates various tumour‐related biological processes, including cell proliferation, metabolism, drug sensitivity, invasion, migration, immune evasion and anti‐tumour. Abstract Background RNA methylation has emerged as a pivotal layer of post‐transcriptional regulation that shapes the biological behavior of cancer ...
PengYuan Dang, KaiBo Li, ZhenQiang Sun
wiley   +1 more source

Prognostic role and mutational characteristics of N6-methyladenosine-related genes in lung adenocarcinoma. [PDF]

Oncol Lett
Yang J, Chu X, Chen Z, Long Y, Chen J.
europepmc   +1 more source

N6-Methyladenosine Regulators and Related LncRNAs Are Potential to be Prognostic Markers for Uveal Melanoma and Indicators of Tumor Microenvironment Remodeling

, 2021
Zhicheng Liu, Shanshan Li, Shan Huang, Tao Wang, Zhicheng Liu   +4 more
openalex   +1 more source

M2 Macrophage‐Derived Migrasomes Mediate Ischaemia‐Induced Retinal Neovascularization by Targeting TREM2

Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
M2 macrophages produced and released TREM2‐enriched migrasomes, which were internalized by HRECs through macropinocytosis and phagocytosis. Subsequently, migrasomes up‐regulated pathological retinal angiogenesis and biological functions of HRECs by targeting downstream molecules (BTC, PLA1A, etc).
Bingyan Li, Junyu Chen, Junye Zhu, Haixiang Zhou, Qiuxiang Zhang, Hui Deng, Haipeng Wen, Fan Xu, Fen Tang, Shigeo Yoshida, Yedi Zhou   +10 more
wiley   +1 more source

Mechanism of KDM5C‐Mediated H3K4me3 Demethylation of HOXC‐AS3 in the Proliferation of Colorectal Cancer Cells

The Kaohsiung Journal of Medical Sciences, Volume 41, Issue 11, November 2025.
ABSTRACT Colorectal cancer (CRC) ranks as the third most prevalent malignancy and the second leading cause of cancer‐related mortality worldwide. This study explored the role of lysine‐specific histone demethylase 5C (KDM5C) in CRC progression. Expression levels of KDM5C, HOXC‐AS3, and discs large MAGUK scaffold protein 4 (DLG4) were evaluated ...
Hong Li, Da‐Min Li, Zhan Wang, Jie Hou
wiley   +1 more source

Regulation of viral hepatitis by N6-methyladenosine RNA methylation. [PDF]

Emerg Microbes Infect
Moon JS, Siddiqui A, Kim GW.
europepmc   +1 more source